Controlled release of methotrexate from W/O microemulsion and its in vitro antitumor activity

Drug Delivery

Volumn 14, Issue 4, 2007, Pages 225-233

  Karasulu, H Yeşim ^a   Karabulut, Bülent ^a   Göker, Erdem ^a   Güneri, Tamer ^a   Gabor, Franz ^b  

^a EGE UNIVERSITY   (Turkey)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Caco 2; Cytotoxic Effect; MCF 7; Methotrexate; Microemulsion; Stability

Indexed keywords

2 PROPANOL; CREMOPHOR; METHOTREXATE; SODIUM HYDROXIDE; SORBITAN OLEATE; SOYBEAN OIL;

ANALYSIS OF VARIANCE; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BREAST CANCER; CELL STRAIN CACO 2; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; IC 50; MICROEMULSION; PRIORITY JOURNAL;

2-PROPANOL; ANTIMETABOLITES, ANTINEOPLASTIC; BREAST NEOPLASMS; CACO-2 CELLS; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EMULSIONS; FEMALE; GLYCEROL; HEXOSES; HUMANS; INHIBITORY CONCENTRATION 50; METHOTREXATE; SODIUM HYDROXIDE; SOLUBILITY; SOYBEAN OIL; SURFACE-ACTIVE AGENTS;

EID: 34248531505     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.1080/10717540601067760     Document Type: Article

References (31)

1. Anta, J. M., Real, F. X., and Mayol, X. 2005. Low tumor cell density environment yield survival advantage of tumor cells exposed to MTX in vitro. Biochimi. Biophys. Acta 1721:98-106.
2. Bartyik, K., Turi, S., Orosz, F., and Karg, E. 2004. Methotrexate inhibits the glyoxalase system in vivo in children with acute lymphoid leukaemia. Eur. J. Cancer 40:2287-1192.
3. Bertino, J. R., Li, W. W., Lin, J., Trippett, T., Goker, E., Schweitzer, B., and Banerjee, D. 1992. Enzymes of thymidylate cyle as targets for chemotherapeutic agents: Mechanism of resistance. Mt. Sinai J. Med. 59(5):391-395.
4. Carli, F., Chiellini, E. E., Bellich, B., Macchiavelli, S., and Cadelli, G. 2005. Ubidercarenone nanoemulsified composite system. Int. J. Pharm. 291:113-118.
5. Charman, S. A., Charman, W. N., Rogge, M. C., Wilson, T. D., Dutko, F. J., and Pouton, C. W. 1992. Self-emulsifying drug delivery systems: formulation and biopharmaceutical evaluation of an investigational lipophilic compound. Pharm. Res. 9:87-93.
6. Constantinides, P. P., and Yiv, S. H. 1995. Particle size determination of phase-inverted water-in-oil microemulsions under different dilution and storage conditions. Int. J. Pharm. 115:225-234.
7. Constantinides, P. P., Scalart, J.-P., Lancaster, C., Marcello, J., Marks, G., Ellens, H., and Smith, P. L. 1994. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medum-chain glycerides. Pharm. Res. 11:1358-1390.
8. DeMario, M. D., and Ratain, M. J. 1999. Oral chemotherapy: rational and future directions. J. Clin. Oncol, 16(7):2557-2567.
9. Ege M. A., Karasulu H. Y., and Güneri T. 2004. Triangle phase diagram analysis software. 4th International Postgraduate Research Symposium on Pharmaceutics (IPORSIP-2004, Istanbul). 36.
10. Fanun, M., Wachtel, E., Antalek, B., Aserin, A., and Garti, N. 2001. A study of the microstructure of four-Gcomponent sucrose ester microemulsions by SAXS and NMR. Colloids Surfaces A: physicochem. Eng. Aspects 180:173-186.
11. Florence, A. T., Hillery, A. M, Hussain, N., and Jani, P. U. 1995. Nanoparticles as carriers for oral peptide absoption: studies on particle uptake and fate. J. Control. Rel. 36:39-46.
12. Francis, M. F., Lavoie, L., Winnik, F. M., and Leroux, J. C. 2003. Solubilization of cyclosperin A in dextran-g-polyethyleneglycolalkyl ether polymeric micelles. Eur. J. Pharmaceut. Biopharmaceut. 56:337-346.
13. Gorlick, R., Goker, E., Trippett, T., Waltham, M., and Banerjee, J. R. 1996 Intrincis and acquired resistance to methotrexate in acute leukaemia. Drug Therapy 335(14):1041-1047.
14. Hansen, J., Kreilgard, B., Nielsen, O., and Veje, J. 1983. Kinetics of degradation of methotrexate in aqueous solution. Int. J. Pharm. 16(2):141-152.
15. Horne, W. D., and Reed, K. 2001. Transport methotrexate into PC-3 human prostate cancer cells. Arch. Biochem. Biophys. 394(1):39-44.
16. Kawakami, K., Yoshikawa, T., Moroto, Y., Kanaoka, E., Takahahi, K., Nishihara, Y., and Masuda, K. 2002a. Microemulsion formulation for enhanced absorption of poorly soluble drugs. I prescription design. J. Control Rel. 81:65-74.
17. Kawakami, K., Yoshikawa, T., Hayashi, T., Nishihara, Y., and Masuda, K. 2002b. Microemulsion formulation for enhanced absorption of poorly soluble drugs. II in vivo study. J. Control Rel. 81:75-82.
18. Kim, C.-K., Ryuu, S. A., Park, K.-M., Lim, S.-L., and Hwang, S. J. 1997. Preparation and physicochemical characterization of phase inverted water-in-oil microemulsions containing cyclosporin A. Int. J. Pharm. 147:131-134.
19. Kim, C.-K., Cho, Y.-J., and Gao, Z.-G. 2001. Preparation and evaluation of biphenyl dimethyl dicarboxylate microemulsions for oral delivery. J. Control Rel. 70:149-155.
20. Kosasih, A., Bowman, B. J., Wigent, R. J., and Ofner III, C. M. 2000. Characterization and formed in vitro release of methotrexate from gelatin/methotrexate conjugates formed using different preparation variables. Int. J. Pharmaceut. 204:81-89.
21. Kurtz, J. E., Andres, E., Natarajan-Amé. S., Noel, E., and Dufour, P. 2003. Oral chemotherapy in colorectal cancer treatment: review of the literature. Eur. J. Inter. Med. 14:18-25.
22. Lawrence, M. J., and Rees, G. D. 2000. Microemulsion-based media as novel drug delivery systems. Adv. Drug Deliv. Rev. 45:89-121.
23. Lowenthal, R. M., and Eaton, K. 1996. Toxicity of chemotherapy. Oncol. Clin. N. Am. 10:967-990.
24. Moutardier, V., Tosini, F., Vlieghe, P., Cara, L., Delpero, J. R., and Clerc, T. 2003. Colloidal anticancer drugs bioavailabilities in oral administration models. Int. J. Pharmaceut. 260:23-38.
25. Park, K. M., and Kim, C. K. 1999. Preparation and evaluation of flurbiprofen-loaded microemulsion for parenteral delivery. Int. J. Pharm. 181:173-179.
26. Shelly, U. A., Khopade, A. J., and Jain, K. 1999. Lipoprotein-mimicking biovectorized systems for methotrexate delivery. Pharm. Acta Helv. 73(6):275-279.
27. Singh, U. V., and Udupa, N. 1997. In vitro characterization of methotrexate loaded poly (lactic-co-glycolic) acid microspheres and antitumor efficacy in sarcoma-180 mice bearing tumor. Pharm. Acta Helv. 72:165-173.
28. Tarr, B. D., and Yalkowsky, S. H. 1989. Enhanced intestinal absorption of cyclosporine in rats through the reduction of emulsion droplet size. Pharm. Res. 6:40-43.
29. Uslu, R., Sanli, U. A., Sezgin, C., Karabulut, B., Terzioǧlu, E., Omay, S. B., and Göker, E. 2000. Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines. Clin. Cancer Res. 6:4957-4964.
30. Weissenböck, A., Wirth, M., and Gabor, F. 2004. WGA-grafted PLGA-nanospheres: preparation and association with Caco-2 single cells. J. Control. Rel. 99(3),Oct 19:383-392.
31. Win, K. Y., and Feng, S. S. 2005. Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. Biomaterials 26:2713-2722.