Lipoprotein-mimicking biovectorized systems for methotrexate delivery

Pharmaceutica Acta Helvetiae

Volumn 73, Issue 6, 1999, Pages 275-279

  Utreja, Shelly ^a   Khopade, A J ^a   Jain, N K ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

Lipoprotein mimicks; Lipospheres; Methotrexate; Pharmacokinetics; Stealth properties; Tissue distribution

Indexed keywords

DRUG CARRIER; LIPOPROTEIN; MACROGOL 4000; METHOTREXATE; NANOPARTICLE; OCTADECYLAMINE; PALMITIC ACID; PHOSPHATIDYLCHOLINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RELEASE; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICROEMULSION; NONHUMAN; PARTICLE SIZE; PARTITION COEFFICIENT; PHARMACOKINETICS; RAT; ZETA POTENTIAL;

EID: 0032805535     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00002-3     Document Type: Article

References (17)

1. Aboofazali R., Lawrence C.B., Wicks S.R., Lawrence M.J. Investigations into the formation and characterization of phospholipid microemulsions: III. Pseudo-ternary phase diagrams of systems containing water-lecithin-isopropyl myristate and either an alkanoic acid, amine alkanediol, polyethylene glycol alkyl ether or alcohol as cosurfactant. Int. J. Pharm. 111:1994;63-72.
2. Bazile D., Homme C.P., Bassoullet M.J., Marlard M., Spenlehaur G., Viellard M. Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system. J. Pharm. Sci. 84(4):1995;493-498.
3. Bijsterbosch M.K., Van Berkel T.J.C. Native and modified lipoproteins as drug delivery systems. Adv. Drug Del. Rev. 5:1990;231-251.
4. British Pharmacopoeia, 1993. International edition, Vol. I. London, p. 419.
5. Calabresi, P., Chabner, B.A., 1991. Chemotherapy of neoplastic diseases. In: Goodman, L.S., Gilman, A. (Eds.), The Pharmacological Basis of Therapeutics. MacMillan, New York, pp. 1202-1227.
6. Cavalli R., Caputo O., Gasco M.R. Solid lipospheres of doxorubicin and idarubicin. Int. J. Pharm. 89:1993;R9-R12.
7. Cavalli R., Morell S., Gasco M.R., Chetoni P., Saettone M.F. Preparation and evaluation in-vitro of colloidal lipospheres containing pilocarpine as ion-pair. Int. J. Pharm. 117:1995;243-246.
8. Counsell E.R., Pohland R.C. Lipoproteins as potential site-specific delivery systems for diagnostic and therapeutic agents. J. Med. Chem. 25(10):1982;1115-1120.
9. Dias, J.M., Dhadke, P.M., 1994. The Royal Society of Chemistry (Anal. Div.) Int. Symp. on Electroanalysis, Cardiff, UK, 6-8 April.
10. Domb A.J. Long-acting injectable oxytetracycline-liposphere formulations. Int. J. Pharm. 124:1995;271-278.
11. Halbert G.W., Stuart J.F.B., Florence A.T. Incorporation of lipid soluble antineoplastic agents into microemulsions protein-free analogues of low density lipoproteins. Int. J. Pharm. 21:1984;219-232.
12. Hassan E.E., Eshra A.G., Nada A.H. Formulation of prolonged release lipid micropellets by emulsion congealing: optimization of ketoprofen entrapment and release. Int. J. Pharm. 121:1995;149-155.
13. Iwamoto K., Kato T., Kawahara M., Koyama N., Wanatabe S., Miyake T., Sunamoto J. Polysaccharide-coated oil droplets in oil-in-water emulsions as targetable carriers for lipophilic drugs. J. Pharm. Sci. 80(3):1991;219-224.
14. Jamshaid M., Farr S.J., Kearway P., Kellaway J.W. Poloxamer sorption on liposomes: comparison with polystyrene latex and influence on solute efflux. Int. J. Pharm. 48:1988;125-131.
15. Khopade A.J., Jain N.K. Self assembling nanostructures for sustained ophthalmic drug delivery. Pharmazie. 50:1995;812-815.
16. Khopade, A.J., Utreja, S., Jain, N.K., 1998. Liposphere based lipoprotein mimicking system for 6-mercaptopurine delivery. Acta Pharmaceutica (in press).
17. Utreja, S., Khopade, A.J., Jain, N.K., 1997. Supramolecular drug delivery. In: Jain, N.K. (Ed.), Controlled and Novel Drug Delivery, CBS Publishers, New Delhi, pp. 390-394.