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Volumn 2, Issue 2, 2007, Pages 75-82

BCR-ABL-negative chronic myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CD135 ANTIGEN; FIBROBLAST GROWTH FACTOR RECEPTOR 1; JANUS KINASE 2; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN TYROSINE KINASE; RAS PROTEIN;

EID: 34248524663     PISSN: 15588211     EISSN: 1558822X     Source Type: Journal    
DOI: 10.1007/s11899-007-0011-5     Document Type: Review
Times cited : (6)

References (49)
  • 1
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman JW, Harris NL, Brunnmg RD: The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 2002, 100:2292-2302.
    • (2002) Blood , vol.100 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunnmg, R.D.3
  • 3
    • 0037108177 scopus 로고    scopus 로고
    • Characteristics and outcome of patients with Philadelphia chromosome negative, bcr/abl negative chronic myelogenous leukemia
    • Onida F, Ball G, Kantarjian HM, et al.: Characteristics and outcome of patients with Philadelphia chromosome negative, bcr/abl negative chronic myelogenous leukemia. Cancer 2002, 95:1673-1684.
    • (2002) Cancer , vol.95 , pp. 1673-1684
    • Onida, F.1    Ball, G.2    Kantarjian, H.M.3
  • 4
    • 0036202529 scopus 로고    scopus 로고
    • Myeloproliferative disorders with translocations of chromosome 5q31-35: Role of the platelet-derived growth factor receptor-β
    • Steer FJ, Cross NCP: Myeloproliferative disorders with translocations of chromosome 5q31-35: role of the platelet-derived growth factor receptor-β. Acta Haematol 2002, 107:113-122.
    • (2002) Acta Haematol , vol.107 , pp. 113-122
    • Steer, F.J.1    Cross, N.C.P.2
  • 5
    • 70350186921 scopus 로고    scopus 로고
    • The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA
    • Baxter EJ, Hochhaus A, Bolufer P, et al.: The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA. Hum Mol Genet 2002, 11:1391-1397.
    • (2002) Hum Mol Genet , vol.11 , pp. 1391-1397
    • Baxter, E.J.1    Hochhaus, A.2    Bolufer, P.3
  • 6
    • 0041335547 scopus 로고    scopus 로고
    • Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: A new clinical target for STI571/Glivec
    • Trempat P, Villalva C, Laurent G, et al.: Chronic myeloproliferative disorders with rearrangement of the platelet-derived growth factor alpha receptor: A new clinical target for STI571/Glivec. Oncogene 2003, 22:5702-5706.
    • (2003) Oncogene , vol.22 , pp. 5702-5706
    • Trempat, P.1    Villalva, C.2    Laurent, G.3
  • 7
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • Cools J, DeAngelo DJ, Gotlib J, et al.: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 2003, 348:1201-1214.
    • (2003) N Engl J Med , vol.348 , pp. 1201-1214
    • Cools, J.1    DeAngelo, D.J.2    Gotlib, J.3
  • 8
    • 0037596569 scopus 로고    scopus 로고
    • Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome
    • Griffin JH, Leung J, Bruner RJ, et al.: Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome. Proc Natl Acad Sci U S A 2003, 100:7830-7835.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 7830-7835
    • Griffin, J.H.1    Leung, J.2    Bruner, R.J.3
  • 9
    • 33646152550 scopus 로고    scopus 로고
    • Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia
    • Score J, Curtis C, Waghorn K, et al.: Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia. Leukemia 2006, 20:827-832.
    • (2006) Leukemia , vol.20 , pp. 827-832
    • Score, J.1    Curtis, C.2    Waghorn, K.3
  • 10
    • 33646532818 scopus 로고    scopus 로고
    • FIP1L1-PDGFRA in eosinophilic disorders: Prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature
    • Pardanani A, Ketterling RP, Li CY, et al.: FIP1L1-PDGFRA in eosinophilic disorders: prevalence in routine clinical practice, long-term experience with imatinib therapy, and a critical review of the literature. Leuk Res 2006, 30:965-970.
    • (2006) Leuk Res , vol.30 , pp. 965-970
    • Pardanani, A.1    Ketterling, R.P.2    Li, C.Y.3
  • 11
    • 33748491495 scopus 로고    scopus 로고
    • Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene
    • Walz C, Curtis C, Schnittger S, et al.: Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA fusion gene. Genes Chromosomes Cancer 2006, 45:950-956.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 950-956
    • Walz, C.1    Curtis, C.2    Schnittger, S.3
  • 12
    • 33744484267 scopus 로고    scopus 로고
    • • Stover EH, Chen J, Folens C, et al.: Activation of FIP1L1-PDGFRα requires disruption of the juxtamembrane domain of PDGFRα and is FIP1L1-independent. Proc Natl Acad Sci U S A 2006, 103:8078-8083. Molecular analysis of PDGFR fusions reveals a new means of kinase activation in MPDs.
    • • Stover EH, Chen J, Folens C, et al.: Activation of FIP1L1-PDGFRα requires disruption of the juxtamembrane domain of PDGFRα and is FIP1L1-independent. Proc Natl Acad Sci U S A 2006, 103:8078-8083. Molecular analysis of PDGFR fusions reveals a new means of kinase activation in MPDs.
  • 13
    • 0344826038 scopus 로고    scopus 로고
    • Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: Involvement of PDGFRB and response to imatinib
    • Wilkinson K, Velloso ER, Lopes LF, et al.: Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Blood 2003, 102:4187-4190.
    • (2003) Blood , vol.102 , pp. 4187-4190
    • Wilkinson, K.1    Velloso, E.R.2    Lopes, L.F.3
  • 14
    • 5644284103 scopus 로고    scopus 로고
    • HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2)
    • Morerio C, Acquila M, Rosanda C, et al.: HCMOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5;17)(q33;p11.2). Cancer Res 2004, 64:2649-2651.
    • (2004) Cancer Res , vol.64 , pp. 2649-2651
    • Morerio, C.1    Acquila, M.2    Rosanda, C.3
  • 15
    • 5644251199 scopus 로고    scopus 로고
    • NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder
    • Vizmanos JL, Novo FJ, Román JP, et al.: NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. Cancer Res 2004, 64:2673-2676.
    • (2004) Cancer Res , vol.64 , pp. 2673-2676
    • Vizmanos, J.L.1    Novo, F.J.2    Román, J.P.3
  • 16
    • 11844290650 scopus 로고    scopus 로고
    • KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q.33;q32)
    • Levine RL, Wadleigh M, Sternberg DW, et al.: KIAA1509 is a novel PDGFRB fusion partner in imatinib-responsive myeloproliferative disease associated with a t(5;14)(q.33;q32). Leukemia 2005, 19:27-30.
    • (2005) Leukemia , vol.19 , pp. 27-30
    • Levine, R.L.1    Wadleigh, M.2    Sternberg, D.W.3
  • 17
    • 5644271514 scopus 로고    scopus 로고
    • p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder
    • Grand FH, Burgstaller S, Kuhr T, et al.: p53-Binding protein 1 is fused to the platelet-derived growth factor receptor beta in a patient with a t(5;15)(q33;q22) and an imatinib-responsive eosinophilic myeloproliferative disorder. Cancer Res 2004, 64:7216-7219.
    • (2004) Cancer Res , vol.64 , pp. 7216-7219
    • Grand, F.H.1    Burgstaller, S.2    Kuhr, T.3
  • 18
    • 33747602537 scopus 로고    scopus 로고
    • TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukaemia
    • Rosati R, La Starza R, Luciano L, ct al.: TPM3/PDGFRB fusion transcript and its reciprocal in chronic eosinophilic leukaemia. Leukemia 2006, 20:1623-1624.
    • (2006) Leukemia , vol.20 , pp. 1623-1624
    • Rosati, R.1    La Starza, R.2    Luciano, L.3    ct al4
  • 19
    • 0030669455 scopus 로고    scopus 로고
    • Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution
    • Abe A, Emi N, Tanimoto M, et al.: Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood 1997, 90:4271-4277.
    • (1997) Blood , vol.90 , pp. 4271-4277
    • Abe, A.1    Emi, N.2    Tanimoto, M.3
  • 20
    • 33845991464 scopus 로고    scopus 로고
    • • David M, Cross NCP, Burgstaller S, et al.: Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders. Blood 2007, 109:61-64. Largest series of PDGFRB-rearranged cases treated with imatinib.
    • • David M, Cross NCP, Burgstaller S, et al.: Durable responses to imatinib in patients with PDGFRB fusion gene-positive and BCR-ABL-negative chronic myeloproliferative disorders. Blood 2007, 109:61-64. Largest series of PDGFRB-rearranged cases treated with imatinib.
  • 21
    • 21344440247 scopus 로고    scopus 로고
    • Molecular classification and pathogenesis of eosinophilic disorders: 2005 update
    • Gotlib J: Molecular classification and pathogenesis of eosinophilic disorders: 2005 update. Acta Haematol 2005, 114:7-25.
    • (2005) Acta Haematol , vol.114 , pp. 7-25
    • Gotlib, J.1
  • 22
    • 0021184596 scopus 로고
    • Simultaneous occurrence of a T-cell lymphoma and a chronic myelogenous leukemia with an unusual karyotype
    • Vannier JP, Bizet M, Bastard C, et al.: Simultaneous occurrence of a T-cell lymphoma and a chronic myelogenous leukemia with an unusual karyotype. Leuk Res 1984, 8:647-657.
    • (1984) Leuk Res , vol.8 , pp. 647-657
    • Vannier, J.P.1    Bizet, M.2    Bastard, C.3
  • 23
    • 0036202064 scopus 로고    scopus 로고
    • The 8p11 myeloproliferative syndrome: A distinct clinical entity caused by constitutive activation of FGFR1 [review]
    • Macdonald D, Reiter A, Cross NCP: The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1 [review]. Acta Haematol 2002, 107:101-107.
    • (2002) Acta Haematol , vol.107 , pp. 101-107
    • Macdonald, D.1    Reiter, A.2    Cross, N.C.P.3
  • 24
    • 0028941132 scopus 로고
    • A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): Description of a distinctive clinicopathologic entity
    • Inhorn RC, Aster JC, Roach SA, et al.: A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity. Blood 1995, 85:1881-1887.
    • (1995) Blood , vol.85 , pp. 1881-1887
    • Inhorn, R.C.1    Aster, J.C.2    Roach, S.A.3
  • 25
    • 0037216062 scopus 로고    scopus 로고
    • Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q1.3.3)
    • Guasch G, Popovici C, Mugneret F, et al.: Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q1.3.3). Blood 2003, 101:286-288.
    • (2003) Blood , vol.101 , pp. 286-288
    • Guasch, G.1    Popovici, C.2    Mugneret, F.3
  • 26
    • 19944432120 scopus 로고    scopus 로고
    • 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes
    • Belloni E, Trubia M, Gasparini P, et al.: 8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes. Genes Chromosomes Cancer 2005, 42:320-325.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 320-325
    • Belloni, E.1    Trubia, M.2    Gasparini, P.3
  • 27
    • 1942422114 scopus 로고    scopus 로고
    • Identification of a novel gene, FGFR1OP2, fused to FGFR1 in the 8p11 myeloproliferative syndrome
    • Grand EK, Grand FH, Chase AJ, et al.: Identification of a novel gene, FGFR1OP2, fused to FGFR1 in the 8p11 myeloproliferative syndrome. Genes Chromosomes Cancer 2003, 40:78-83.
    • (2003) Genes Chromosomes Cancer , vol.40 , pp. 78-83
    • Grand, E.K.1    Grand, F.H.2    Chase, A.J.3
  • 28
    • 20844443647 scopus 로고    scopus 로고
    • The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1
    • Walz C, Chase A, Schoch C, et al.: The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1. Leukemia 2005, 19:1005-1009.
    • (2005) Leukemia , vol.19 , pp. 1005-1009
    • Walz, C.1    Chase, A.2    Schoch, C.3
  • 29
    • 0035895067 scopus 로고    scopus 로고
    • The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: Transforming activity and specific inhibition of FGFR1 fusion proteins
    • Demiroglu A, Steer EJ, Heath C, et al.: The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins. Blood 2001, 98:3778-3783.
    • (2001) Blood , vol.98 , pp. 3778-3783
    • Demiroglu, A.1    Steer, E.J.2    Heath, C.3
  • 30
    • 11044238012 scopus 로고    scopus 로고
    • Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: Two further cases
    • Vizmanos JL, Hernandez R, Vidal MJ, et al.: Clinical variability of patients with the t(6;8)(q27;p12) and FGFR1OP-FGFR1 fusion: two further cases. Hematol J 2004, 5:534-537.
    • (2004) Hematol J , vol.5 , pp. 534-537
    • Vizmanos, J.L.1    Hernandez, R.2    Vidal, M.J.3
  • 31
    • 1642421743 scopus 로고    scopus 로고
    • • Roumiantsev S, Krause DS, Neumann CA, et al.: Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell 2004, 5:287-298.
    • • Roumiantsev S, Krause DS, Neumann CA, et al.: Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell 2004, 5:287-298.
  • 32
    • 33749364564 scopus 로고    scopus 로고
    • Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia
    • Lin P, Jones D, Medeiros LJ, et al.: Activating FLT3 mutations are detectable in chronic and blast phase of chronic myeloproliferative disorders other than chronic myeloid leukemia. Am J Clin Pathol 2006, 126:530-533.
    • (2006) Am J Clin Pathol , vol.126 , pp. 530-533
    • Lin, P.1    Jones, D.2    Medeiros, L.J.3
  • 33
    • 33746169020 scopus 로고    scopus 로고
    • FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation
    • Vu HA, Xinh PT, Masuda M, et al.: FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation. Leukemia 2006, 20:1414-1421.
    • (2006) Leukemia , vol.20 , pp. 1414-1421
    • Vu, H.A.1    Xinh, P.T.2    Masuda, M.3
  • 34
    • 15444339209 scopus 로고    scopus 로고
    • A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Valle VD, et al.: A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science 1997, 278:1309-1312.
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3
  • 35
    • 0030852328 scopus 로고    scopus 로고
    • Peeters P, Raynaud SD, Cools J, et al.: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997, 90:2535-2540.
    • Peeters P, Raynaud SD, Cools J, et al.: Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood 1997, 90:2535-2540.
  • 36
    • 20144389913 scopus 로고    scopus 로고
    • The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2
    • Reiter A, Walz C, Watmore A, et al.: The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2. Cancer Res 2005, 65:2662-2667.
    • (2005) Cancer Res , vol.65 , pp. 2662-2667
    • Reiter, A.1    Walz, C.2    Watmore, A.3
  • 37
    • 25844469587 scopus 로고    scopus 로고
    • A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia
    • Griesinger F, Hennig H, Hillmer F, et al.: A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia. Genes Chromosomes Cancer 2005, 44:329-333.
    • (2005) Genes Chromosomes Cancer , vol.44 , pp. 329-333
    • Griesinger, F.1    Hennig, H.2    Hillmer, F.3
  • 39
    • 21344467318 scopus 로고    scopus 로고
    • Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
    • Jones AV, Kreil S, Zoi K, et al.: Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders. Blood 2005, 106:2162-2168.
    • (2005) Blood , vol.106 , pp. 2162-2168
    • Jones, A.V.1    Kreil, S.2    Zoi, K.3
  • 40
    • 21344440357 scopus 로고    scopus 로고
    • The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes
    • Steensma DP, Dewald GW, Lasho TL, et al.: The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both "atypical" myeloproliferative disorders and myelodysplastic syndromes. Blood 2005, 106:1207-1209.
    • (2005) Blood , vol.106 , pp. 1207-1209
    • Steensma, D.P.1    Dewald, G.W.2    Lasho, T.L.3
  • 41
    • 25844447519 scopus 로고    scopus 로고
    • JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia
    • Jelinek J, Oki Y, Gharibyan V, et al.: JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia. Blood 2005, 106:3370-3373.
    • (2005) Blood , vol.106 , pp. 3370-3373
    • Jelinek, J.1    Oki, Y.2    Gharibyan, V.3
  • 42
    • 33845501610 scopus 로고    scopus 로고
    • Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia
    • Gu TL, Goss VL, Reeves C, et al.: Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood 2006, 108:4202-4204.
    • (2006) Blood , vol.108 , pp. 4202-4204
    • Gu, T.L.1    Goss, V.L.2    Reeves, C.3
  • 43
    • 0035367160 scopus 로고    scopus 로고
    • BCR rearrangement-negative chronic myelogenous leukemia revisited
    • Kurzrock R, Bueso-Ramos CE, Kantarjian H, et al.: BCR rearrangement-negative chronic myelogenous leukemia revisited. J Clin Oncol 2001, 19:2915-2926.
    • (2001) J Clin Oncol , vol.19 , pp. 2915-2926
    • Kurzrock, R.1    Bueso-Ramos, C.E.2    Kantarjian, H.3
  • 44
    • 5144234541 scopus 로고    scopus 로고
    • PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
    • Chen J, DeAngelo DJ, Kutok JL, et al.: PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc Natl Acad Sci U S A 2004, 101:14479-14484.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14479-14484
    • Chen, J.1    DeAngelo, D.J.2    Kutok, J.L.3
  • 45
    • 33745102555 scopus 로고    scopus 로고
    • Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
    • Talpaz M, Shah NP, Kantarjian H, et al.: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med 2006, 354:2531-2541.
    • (2006) N Engl J Med , vol.354 , pp. 2531-2541
    • Talpaz, M.1    Shah, N.P.2    Kantarjian, H.3
  • 46
    • 33745086350 scopus 로고    scopus 로고
    • Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL
    • Kantarjian H, Giles F, Wunderle L, et al.: Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL. N Engl J Med 2006, 354:2542-2551.
    • (2006) N Engl J Med , vol.354 , pp. 2542-2551
    • Kantarjian, H.1    Giles, F.2    Wunderle, L.3
  • 47
    • 27144551665 scopus 로고    scopus 로고
    • The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo
    • Stover EH, Chen J, Lee BH, et al.: The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo. Blood 2005, 106:3206-3213.
    • (2005) Blood , vol.106 , pp. 3206-3213
    • Stover, E.H.1    Chen, J.2    Lee, B.H.3
  • 48
    • 33747203008 scopus 로고    scopus 로고
    • Sorafenib (BAY 43-9006) is a potent inhibitor of FIP1L1-PDGFRA and the imatinib resistant FIP1L1-PDGFRA T674I mutant
    • Lierman E, Folens C, Stover EH, et al.: Sorafenib (BAY 43-9006) is a potent inhibitor of FIP1L1-PDGFRA and the imatinib resistant FIP1L1-PDGFRA T674I mutant. Blood 2006, 108:1374-1376.
    • (2006) Blood , vol.108 , pp. 1374-1376
    • Lierman, E.1    Folens, C.2    Stover, E.H.3
  • 49
    • 33744999628 scopus 로고    scopus 로고
    • Tefferi A, Gilliland G: Classification of chronic myeloid disorders: From Dameshek towards a semi-molecular system
    • • Tefferi A, Gilliland G: Classification of chronic myeloid disorders: From Dameshek towards a semi-molecular system. Best Bract Res Clin Haematol 2006, 19:365-385.
    • (2006) Best Bract Res Clin Haematol , vol.19 , pp. 365-385


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.