Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells

Radiation Oncology

Volumn 2, Issue 1, 2007, Pages

  Itani, Wafica ^a   Geara, Fady ^a   Haykal, Joelle ^a   Haddadin, Makhluf ^a   Gali Muhtasib, Hala ^a  

^a AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZOYL 3 PHENYL 6,7 DICHLOROQUINOXALINE 1,4 DIOXIDE; 2-BENZOYL-3-PHENYL-6,7-DICHLOROQUINOXALINE-1,4-DIOXIDE; OXYGEN; QUINOXALINE DERIVATIVE; RADIOSENSITIZING AGENT;

ANOXIA; APOPTOSIS; ARTICLE; CELL CYCLE; COLON TUMOR; COMET ASSAY; DNA DAMAGE; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; INTESTINE; METABOLISM; METHODOLOGY; NICK END LABELING; ONCOLOGY; PATHOLOGY; TUMOR CELL LINE;

ANOXIA; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; COLONIC NEOPLASMS; COMET ASSAY; DNA DAMAGE; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; INTESTINES; OXYGEN; QUINOXALINES; RADIATION ONCOLOGY; RADIATION-SENSITIZING AGENTS;

EID: 34248388023     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-2-1     Document Type: Article

References (27)

1. Hockel M Vaupel P Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects J Natl Cancer Inst 2001 93 266-276 10.1093/jnci/93.4.266 11181773
2. Vaupel P Tumor Microenvironmental Physiology and its Implications for Radiation Oncology Semin Radiat Oncol 2004 14 198-206 10.1016/ j.semradonc.2004.04.008 15254862
3. Weinmann M Welz S Bamberg M Hypoxic radiosensitizers and hypoxic cytotoxins in radiation oncology Curr Med Chem: Anti-Cancer Agents 2003 3 364-374 10.2174/1568011033482350
4. Phillips RM Jaffar M Maitland DJ Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs Biochem Pharmacol 2004 68 2107-2116 10.1016/j.bcp.2004.08.007 15498501
5. Brown JM Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies Mol Med Today 2000 6 157-162 10.1016/S1357-4310(00)01677-4 10740254
6. Ganley B Chowdhury G Bhansali J Daniels JS Gates KS Redox-Activated, Hypoxia-Selective DNA Cleavage by Quinoxaline 1,4-di-N-Oxide Bioorganic & Medicinal Chemistry 2001 9 2395-2401 10.1016/S0968-0896(01)00163-8 11553481
7. Ortega MA Morancho MJ Martinez-Crespo FJ New quinoxaline carbonitrite 1,4-di-N-oxide derivatives as hypoic cytotoxic agents Eur J Med Chem 2000 35 21-30 10.1016/S0223-5234(00)00112-4 10733600
8. Diab-Assef M Haddadin M Yared P Assaad C Gali-Muhtasib H Quinoxaline 1,4-Dioxides: Hypoxia-Selective Therapeutic Agents Molecular Carcinogenesis 2002 33 198-205 10.1002/mc.10036 11933073
9. Gali-Muhtasib H Sidani M Geara F Assaf-Diab M Al-Hmaira J Haddadin M Zaatari G Quinoxaline 1,4-dioxides are novel angiogenesis inhibitors that potentiate antitumor effects of ionizing radiation Int J Onco 2004 24 1121-1131
10. Haddadin M Issidorides C The Beirut Reaction Heterocycles 1993 35 1503-1525
11. Dhawan A Bajpayee M Pandy AK Parmar D Protocol For The Single Gel Electrophoreisis/Comet Assay For Rapid Genotoxicity Assessment ITRC: The SCGE/Comet Protocol 2005
12. Kubbutat M Jones S Vousden K Regulation of p53 stability by Mdm2 Nature 1997 387 299-303 10.1038/387299a0 9153396
13. El-Deiry W Regulation of p53 downstream genes Cancer Biol 1998 8 345-357 10.1006/scbi.1998.0097
14. Brugarolas J Moberg K Boyd S Inhibition of cyclin-dependent kinase 2 by p21 is necessary for retinoblastoma protein-mediated G1 arrest after gamma-irradiation Proc Natl Acad Sci USA 1999 961 1002-1007 10.1073/ pnas.96.3.1002
15. Fukuchi K Watanabe H Tomoyasu S Phosphotidyl 3-kinase inhibitors, Wortmannin or LY294002 inhibited accumulation of p21 protein after γ-irradiation by stabilization of the protein Biochim Biophys Acta 1496 207-220 10771089
16. Davis TW Hunter N Trifan OC Milas L Masferrer JL COX-2 Inhibitors as Radiosensitizing Agents for Cancer Therapy Am J Clin Oncol (CCT) 2003 26 S58-S61
17. Ueta E Yoneda K Kimura Mn-SOD antisense upregulates in vivo apoptosis of squamous cell carcinoma cells by anticancer drugs and γ-rays regulating expression of the BcL-2 family proteins, COX-2 and p21 Int J Cancer 2001 94 545-550 10.1002/ijc.1513 11745442
18. Liu X Kirschenbaum A Yu K Yao S Levine A Cyclooxygenase-2 Suppresses Hypoxia-induced Apoptosis via a Combination of Direct and Indirect Inhibition of p53 Activity in a Human Prostate Cancer Cell Line J Biol Chem 2005 280 3817-3823 10.1074/jbc.M406577200 15550400
19. Kaanders J Bussink J van der Kogel A Clinical Studies of Hypoxia Modification in Radiotherapy Semin Radiat Oncol 2004 14 233-240 10.1016/ j.semradonc.2004.04.002 15254866
20. Staszewska A Stefanowicz P Szewczuk Z Direct solid-phase synthesis of quinoxaline-containing peptides Tetrahedron Lett 2005 46 5525-5528 10.1016/j.tetlet.2005.06.047
21. Matsui Y Tsuchida Y Keng PC Effects of p53 mutations on cellular sensitivity to ionizing radiation Am J Clin Oncol 2001 24 486-90 10.1097/ 00000421-200110000-00014 11586101
22. Chandel NS Vander HM Thompson CB Schumacker PT Redox regulation of p53 during hypoxia Oncogene 2000 19 3840-8 10.1038/sj.onc.1203727 10951577
23. Samuni A Kasid U Chuang E Effects of Hypoxia on Radiation-Responsive Stress-Activated Protein Kinase, p53, and Caspase 3 Signals in TK6 Human Lymphoblastoid Cells Cancer Res 2005 65 579-86 15695402
24. El-Deiry W The role of p53 in chemosensitivity and radiosensitivity Oncogene 2003 22 7486-7495 10.1038/sj.onc.1206949 14576853
25. Cuisnier O Serduc R Lavieille JP Longuet M Reyt E Riva C Chronic hypoxia protects against γ-irradiation-induced apoptosis by inducing bcl-2 up-regulation and inhibiting mitochondrial translocation and conformational change of bax protein Int J Onco 2003 23 1033-1041
26. Prise KM Schettino G Folkard M Held KD New insights on cell death from radiation exposure Lancet Oncol 2005 6 520-28 10.1016/ S1470-2045(05)70246-1 15992701
27. Choy H Milas L Enhancing Radiotherapy With Cyclooxygenase-2 Enzyme Inhibitors: A Rational Advance? J Natl Cancer Inst 2003 95 1440-52 14519750