Cyclooxygenase-2 suppresses hypoxia-induced apoptosis via a combination of direct and indirect inhibition of p53 activity in a human prostate cancer cell line

Journal of Biological Chemistry

Volumn 280, Issue 5, 2005, Pages 3817-3823

  Liu, Xin Hua ^a   Kirschenbaum, Alexander ^a   Yu, Kang ^b   Yao, Shen ^a   Levine, Alice C ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CARDIOVASCULAR SYSTEM; CATALYSIS; CYTOLOGY; ENZYME INHIBITION; ENZYMES; GENES; GENETIC ENGINEERING; MUTAGENESIS; TUMORS;

APOPTOSIS; CELL LINES; CYCLOOXYGENASE-2; MUTATIONS;

ENZYME KINETICS;

ARACHIDONIC ACID; CYCLOOXYGENASE 2; ICOSANOID; PROSTAGLANDIN; PROTEIN MDM2; PROTEIN P53;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER CELL; CATALYSIS; CELL PROLIFERATION; CELL VIABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MUTATION; NICK END LABELING; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; TRANSCRIPTION INITIATION; WILD TYPE;

ANOXIA; APOPTOSIS; CELL LINE, TUMOR; CELL NUCLEUS; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MEMBRANE PROTEINS; NUCLEAR PROTEINS; OXYGEN; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTATIC NEOPLASMS; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; SERINE; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 13544260878     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406577200     Document Type: Article

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