Toxicity of diazinon and its metabolites increases in diabetic rats

Toxicology Letters

Volumn 170, Issue 3, 2007, Pages 229-237

  Ueyama, Jun ^a,b   Wang, Dong ^b   Kondo, Takaaki ^b   Saito, Isao ^c   Takagi, Kenji ^b   Takagi, Kenzo ^b   Kamijima, Michihiro ^d   Nakajima, Tamie ^d   Miyamoto, Ken Ichi ^a   Wakusawa, Shinya ^b   Hasegawa, Takaaki ^e  

^a KANAZAWA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c Food Safety and Quality Research Center   (Japan)

^d NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Dialkylphosphate; Diazinon; Hepatic cytochrome P450 (CYP); Organophosphorus pesticide

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE; CYTOCHROME P450 1A2; CYTOCHROME P450 3A2; DIETHYLTHIOPHOSPHATE; DIMPYLATE; ORGANOPHOSPHATE; PHENAZONE DERIVATIVE; PHOSPHORIC ACID DIETHYL ESTER; STREPTOZOCIN; UNCLASSIFIED DRUG;

ACETYLCHOLINE BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER CLEARANCE; LIVER METABOLISM; LIVER MICROSOME; LIVER MICROSOME METABOLISM; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES; URINE LEVEL;

ACETYLCHOLINESTERASE; ANIMALS; BLOTTING, WESTERN; BODY WEIGHT; BRAIN; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DIABETES MELLITUS, EXPERIMENTAL; DIAZINON; ERYTHROCYTES; INSECTICIDES; LIVER; MALE; ORGAN SIZE; RATS; RATS, WISTAR;

RATTUS;

EID: 34248215180     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2007.03.010     Document Type: Article

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