Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters

European Journal of Pharmacology

Volumn 510, Issue 1-2, 2005, Pages 127-134

  Ueyama, Jun ^a   Nadai, Masayuki ^b   Kanazawa, Hiroaki ^c   Iwase, Mitsunori ^d   Nakayama, Hironao ^a   Hashimoto, Katsunori ^a   Yokoi, Toyoharu ^a   Baba, Kenji ^e   Takagi, Kenji ^a   Takagi, Kenzo ^a   Hasegawa, Takaaki ^e  

^a NAGOYA UNIVERSITY   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

^d TOYOTA MEMORIAL HOSPITAL   (Japan)

^e AICHI MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

(Rat); Antipyrine clearance; CYP2C11; CYP3A2; Endotoxin; P glycoprotein

Indexed keywords

CARRIER PROTEIN; CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 3A2; DRUG METABOLIZING ENZYME; ENDOTOXIN; GLYCOPROTEIN P; LIVER PROTEIN; MULTIDRUG RESISTANCE PROTEIN 2; PHENAZONE;

ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; ENZYME ACTIVITY; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; KLEBSIELLA PNEUMONIAE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; RAT; WESTERN BLOTTING;

EID: 20044371597     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.01.025     Document Type: Article

References (58)

1. H. Ando, Y. Nishio, K. Ito, A. Nakao, L. Wang, Y.L. Zhao, K. Kitaichi, K. Takagi, and T. Hasegawa Effect of endotoxin on P-glycoprotein-mediated biliary and renal excretion of rhodamine-123 in rats Antimicrob. Agents Chemother. 45 2001 3462 3467
2. S.K. Balani, T. Zhu, J. Yang, Z. Liu, B. He, and F.W. Lee Effective dosing regimen of 1-aminobenzotriazole for inhibition of antipyrine clearance in rats, dogs, and monkeys Drug Metab. Dispos. 30 2002 1059 1062
3. R. Bertini, M. Bianchi, A. Erroi, P. Villa, and P. Ghezzi Dexamethasone modulation of in vivo effects of endotoxin, tumor necrosis factor, and interleukin-1 on liver cytochrome P-450, plasma fibrinogen, and serum iron J. Leukoc. Biol. 46 1989 254 262
4. D.S. Bredt, and S.H. Snyder Nitric oxide: a physiologic messenger molecule Annu. Rev. Biochem. 63 1994 175 195
5. J.A. Carcillo, L. Doughty, D. Kofos, R.F. Frye, S.S. Kaplan, H. Sasser, and G.J. Burckart Cytochrome P450 mediated-drug metabolism is reduced in children with sepsis-induced multiple organ failure Intensive Care Med. 29 2003 980 984
6. M.A. Cassatella, L. Meda, S. Bonora, M. Ceska, and G. Constantin Interleukin 10 (IL-10) inhibits the release of proinflammatory cytokines from human polymorphonuclear leukocytes. Evidence for an autocrine role of tumor necrosis factor and IL-1 beta in mediating the production of IL-8 triggered by lipopolysaccharide J. Exp. Med. 178 1993 2207 2211
7. C. Cordon-Cardo, J.P. O'Brien, J. Boccia, D. Casals, J.R. Bertino, and M.R. Melamed Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues J. Histochem. Cytochem. 38 1990 1277 1287
8. E.K. Crawford, J.E. Ensor, I. Kalvakolanu, and J.D. Hasday The role of 3′ poly(A) tail metabolism in tumor necrosis factor-alpha regulation J. Biol. Chem. 272 1997 21120 21127
9. T.J. Evans, E. Strivens, A. Carpenter, and J. Cohen Differences in cytokine response and induction of nitric oxide synthase in endotoxin-resistant and endotoxin-sensitive mice after intravenous gram-negative infection J. Immunol. 150 1993 5033 5040
10. H.D. Flad, H. Loppnow, E.T. Rietschel, and A.J. Uimer Agonists and antagonists for lipopolysaccharide-induced cytokines Immunobiology 187 1993 303 316
11. M.A. Freudenberg, D. Keppler, and C. Galanos Requirement for lipopolysaccharide-responsive macrophages in galactosamine-induced sensitization to endotoxin Infect. Immun. 51 1986 891 895
12. J.T.M. Frieling, J.A. Mulder, T. Hendriks, J.H.A. Curfs, C.J. Van der Linden, and R.W. Sauerwein Differential induction of pro- and anti-inflammatory cytokines in whole blood by bacteria: effects of antibiotic treatment Antimicrob. Agents Chemother. 41 1997 1439 1443
13. R.M. Green, D. Beier, and J.L. Gollan Regulation of hepatocytes bile salt transporters by endotoxin and inflammatory cytokines in rodents Gastroenterology 111 1996 193 198
14. G. Hartmann, H. Kim, and M. Piquette-Miller Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice Int. Immunopharmacol. 1 2001 189 199
15. G. Hartmann, A.K.Y. Cheung, and M. Piquette-Miller Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia J. Pharmacol. Exp. Ther. 303 2002 273 281
16. J.A. Hewett, and R.A. Roth Hepatic and extrahepatic pathobiology of bacterial lipopolysaccharides Pharmacol. Rev. 45 1993 381 411
17. K. Hirata, A. Kaneko, K. Ogawa, H. Hayasaka, and T. Onoe Effect of endotoxin on rat liver. Analysis of acid phosphatase isozymes in the liver of normal and endotoxin-treated rats Lab. Invest. 43 1980 165 171
18. L. Jette, E. Beaulieu, J.M. Leclerc, and R. Beliveau Cyclosporin A treatment induces overexpression of P-glycoprotein in the kidney and other tissues Am. J. Physiol. 270 1996 F756 F765
19. N. Kato, N. Kido, M. Ohta, S. Naito, and I. Nakashima Adjuvant activity of Klebsiella O3 lipopolysaccharide: comparative study using defined uniform salt forms Microbiol. Immunol. 28 1984 659 666
20. N. Kato, N. Kido, M. Ohta, and S. Naito Adjuvant activity of Klebsiella O3 lipopolysaccharide: inhibition of the adjuvant activity by concanavalin A Microbiol. Immunol. 29 1985 205 211
21. O.G. Khatsenko, and Y. Kikkawa Nitric oxide differentially affects constitutive cytochrome P450 isoforms in rat liver J. Pharmacol. Exp. Ther. 280 1997 1463 1470
22. O.G. Khatsenko, S.S. Gross, A.B. Rifkind, and J.R. Vane Nitric oxide is a mediator of the decrease in cytochrome P450-dependent metabolism caused by immunostimulants Proc. Natl. Acad. Sci. U. S. A. 90 1993 11147 11151
23. K. Kitaichi, L. Wang, K. Takagi, M. Iwase, E. Shibata, M. Nadai, K. Takagi, and T. Hasegawa Decreased antipyrine clearance following endotoxin administration: in vivo evidence of the role of nitric oxide Antimicrob. Agents Chemother. 43 1999 2697 2701
24. S. Magnusson, and T. Berg Endocytosis of ricin by rat liver cells in vivo and in vitro is mainly mediated by mannose receptors on sinusoidal endothelial cells Biochem. J. 291 1993 749 755
25. G. Mathiak, K. Kabir, G. Grass, H. Keller, E. Steinringer, T. Minor, C. Rangger, and L. Neville Lipopolysaccharides from different bacterial sources elicit disparate cytokine responses in whole blood assays Int. J. Mol. Med. 11 2003 41 44
26. R. Mayer, J. Kartenbeck, M. Buchler, G. Jedlitschky, I. Leier, and D. Kuppler Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes J. Cell Biol. 131 1995 137 150
27. Y. Minamiyama, S. Takemura, S. Imaoka, Y. Funae, Y. Tanimoto, and M. Inoue Irreversible inhibition of cytochrome P450 by nitric oxide J. Pharmacol. Exp. Ther. 283 1998 1479 1485
28. S. Moncada, R.M. Palmer, and E.A. Higgs Nitric oxide: physiology, pathophysiology, and pharmacology Pharmacol. Rev. 43 1991 109 142
29. M. Monshouwer, R.F. Witkamp, S.M. Nijmeijer, L.A. Van Leengoed, H.C. Vernooy, J.H. Verheijden, and A.S. Van Miert A lipopolysaccharide-induced acute phase response in the pig is associated with a decrease in hepatic cytochrome P450-mediated drug metabolism J. Vet. Pharmacol. Ther. 19 1996 382 388
30. E.T. Morgan Regulation of cytochrome P450 during inflammation and infection Drug Metab. Rev. 29 1997 1129 1188
31. M. Nadai, T. Sekido, I. Matsuda, W. Li, K. Kitaichi, A. Itoh, T. Nabeshima, and T. Hasegawa Time-dependent effects of Klebsiella pneumoniae endotoxin on hepatic drug-metabolizing enzyme activity in rats J. Pharm. Pharmacol. 50 1998 871 879
32. M. Nadai, Y.L. Zhao, L. Wang, Y. Nishio, K. Takagi, K. Kitaichi, K. Takagi, H. Yoshizumi, and T. Hasegawa Endotoxin impairs biliary transport of sparfloxacin and its glucuronide in rats Eur. J. Pharmacol. 432 2001 99 105
33. J. Nakamura, T. Nishida, K. Hayashi, N. Kawada, S. Ueshima, Y. Sugiyama, T. Ito, K. Sobue, and H. Matsuda Kupffer cell-mediated down regulation of rat hepatic CMOAT/MRP2 gene expression Biochem. Biophys. Res. Commun. 255 1999 143 149
34. M.G. Netea, B.J. Kullberg, L.A. Joosten, T. Sprong, I. Verschueren, O.C. Boerman, F. Amiot, W.B. van den Berg, and J.W. Van der Meer Lethal Escherichia coli and Salmonella typhimurium endotoxemia is mediated through different pathways Eur. J. Immunol. 31 2001 2529 2538
35. M. Ohta, I. Nakashima, and N. Kato Adjuvant action of bacterial lipopolysaccharide in induction of delayed-type hypersensitivity to protein antigens. I. Action of the O3 antigen of Klebsiella from culture fluid Cell. Immunol. 66 1982 111 120
36. M. Ohta, I. Nakashima, and N. Kato Adjuvant action of bacterial lipopolysaccharide in induction of delayed-type hypersensitivity to protein antigens. II. Relationships of intensity of the action to that of other immunological activities Immunobiology 163 1982 460 469
37. M. Ohta, N. Kido, T. Hasegawa, H. Ito, Y. Fujii, Y. Arakawa, T. Komatsu, and N. Kato Contribution of the mannan O side-chains to the adjuvant action of lipopolysaccharides Immunology 60 1987 503 507
38. T. Omura, and R. Sato The carbon monoxide-binding pigment of liver microsomes J. Biol. Chem. 237 1964 2370 2378
39. R.P. Oude Elferink, D.K. Meijer, F. Kuipers, P.L. Jansen, A.K. Groen, and G.M. Groothuis Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport Biochim. Biophys. Acta 1241 1995 215 268
40. E.T. Rietschel, T. Kirikae, F.U. Schade, A.J. Ulmer, O. Holst, H. Brade, G. Schmidt, U. Mamat, H.D. Grimmecke, and S. Kusumoto The chemical structure of bacterial endotoxin in relation to bioactivity Immunobiology 187 1993 169 190
41. A.H. Schinkel, E. Wagenaar, C.A. Mol, and L. van Deemter P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs J. Clin. Invest. 97 1996 2517 2524
42. A.H. Schinkel, U. Mayer, E. Wagenaar, C.A. Mol, L. van Deemter, J.J. Smit, M.A. van der Valk, A.C. Voordouw, H. Spits, O. van Tellingen, J.M. Zijlmans, W.E. Fibbe, and P. Borst Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins Proc. Natl. Acad. Sci. U. S. A. 94 1997 4028 4032
43. E.G. Schuetz, W.T. Beck, and J.D. Schuetz Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells Mol. Pharmacol. 49 1996 311 318
44. M.B. Sewer, and E.T. Morgan Nitric oxide-independent suppression of P450 2C11 expression by interleukin-1beta and endotoxin in primary rat hepatocytes Biochem. Pharmacol. 54 1997 729 737
45. M.B. Sewer, and E.T. Morgan Down-regulation of the expression of three major rat liver cytochrome P450s by endotoxin in vivo occurs independently of nitric oxide production J. Pharmacol. Exp. Ther. 287 1998 352 358
46. M.B. Sewer, D.R. Koop, and E.T. Morgan Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450 Drug Metab. Dispos. 24 1996 401 407
47. M.B. Sewer, T.B. Barclay, and E.T. Morgan Down-regulation of cytochrome P450 mRNAs and proteins in mice lacking a functional NOS2 gene Mol. Pharmacol. 54 1998 273 279
48. S.I. Shedlofsky, B.C. Israel, C.J. McClain, D.B. Hill, and R.A. Blouin Endotoxin administration to humans inhibits hepatic cytochrome P450-mediated drug metabolism J. Clin. Invest. 94 1994 2209 2214
49. P. Souček, and I. Gut Cytochromes P-450 in rats: structures, functions, properties and relevant human forms Xenobiotica 22 1992 83 103
50. W. Tang, C. Yi, J. Kalitsky, and M. Piquette-Miller Endotoxin downregulates hepatic expression of P-glycoprotein and MRP2 in 2-acetylaminofluorene-treated rats Mol. Cell Biol. Res. Commun. 4 2000 90 97
51. F. Thiebaut, T. Tsuruo, H. Hamada, M.M. Gottesman, I. Pastan, and M.C. Willingham Cellular localization of multidrug-resistance gene product P-glycoprotein in normal human tissues Proc. Natl. Acad. Sci. U. S. A. 84 1987 7735 7738
52. M. Trauner, M. Arrese, C.J. Soroka, M. Ananthanarayanan, T.A. Koeppel, S.F. Schlosser, F.J. Suchy, D. Keppler, and J.L. Boyer The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis Gastroenterology 113 1997 255 264
53. J. Ueyama, K. Kitaichi, M. Nadai, M. Iwase, N. Tomyo, H. Kanazawa, R. Suzuki, K. Takagi, K. Takagi, and T. Hasegawa Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11 Eur. J. Pharmacol. 498 2004 257 265
54. T.A. Vos, G.J. Hooiveld, H. Koning, S. Childs, D.K. Meijer, H. Moshage, P.L. Jansen, and M. Muller Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter. Spgp, in endotoxemic rat liver Hepatology 28 1998 1637 1644
55. V.J. Wacher, C.Y. Wu, and L.Z. Benet Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy Mol. Carcinog. 13 1995 129 134
56. D. Waxman Interactions of hepatic cytochromes P450 with steroid hormones Biochem. Pharmacol. 37 1988 71 84
57. O. Westphal, K. Jann, and K. Himmelspach Chemistry and immunochemistry of bacterial lipopolysaccharides as cell wall antigens and endotoxins Prog. Allergy 33 1983 9 39
58. Y.L. Zhao, J. Du, H. Kanazawa, A. Sugawara, K. Takagi, K. Kitaichi, Y. Tatsumi, K. Takagi, and T. Hasegawa Effect of endotoxin on doxorubicin transport across blood-brain barrier and P-glycoprotein function in mice Eur. J. Pharmacol. 445 2002 115 123