PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger

Molecular and Cellular Biology

Volumn 27, Issue 10, 2007, Pages 3780-3792

  Deng, Zhiyong ^a   Wan, Meimei ^a   Sui, Guangchao ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; LYSINE; PROTEIN P53; SUMO PROTEIN; TRANSCRIPTION FACTOR YY1; UBIQUITIN PROTEIN LIGASE COP1;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ENZYME LOCALIZATION; IN VITRO STUDY; IN VIVO STUDY; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STABILITY; REGULATORY MECHANISM; SUMOYLATION; TRANSCRIPTION INITIATION;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GENE EXPRESSION REGULATION; HUMANS; LYSINE; MOLECULAR SEQUENCE DATA; PROTEIN INHIBITORS OF ACTIVATED STAT; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SUMO-1 PROTEIN; UBIQUITIN-CONJUGATING ENZYMES; YY1 TRANSCRIPTION FACTOR;

EID: 34248209648     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01761-06     Document Type: Article

References (69)

1. Atchison, L., A. Ghias, F. Wilkinson, N. Bonini, and M. L. Atchison. 2003. Transcription factor YY1 functions as a PcG protein in vivo. EMBO J. 22:1347-1358.
2. Azuma, Y., A. Arnaoutov, T. Anan, and M. Dasso. 2005. PIASy mediates SUMO-2 conjugation of topoisomerase-II on mitotic chromosomes. EMBO J. 24:2172-2182.
3. Baek, S. H. 2006. A novel link between SUMO modification and cancer metastasis. Cell Cycle 5:1492-1495. [Epub ahead of print 17 July 2006.]
4. Bayer, P., A. Arndt, S. Metzger, R. Mahajan, F. Melchior, R. Jaenicke, and J. Becker. 1998. Structure determination of the small ubiquitin-related modifier SUMO-1. J. Mol. Biol. 280:275-286.
5. Becker, K. G., P. Jedlicka, N. S. Templeton, L. Lietta, and K. Ozato. 1994. Characterization of hUCRBP (YY1, NF-E1, delta): a transcription factor that binds the regulatory regions of many viral and cellular genes. Gene 150:259-266.
6. Begon, D. Y., L. Delacroix, D. Vernimmen, P. Jackers, and R. Winkler. 2005. Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells. J. Biol. Chem. 280:24428-24434.
7. Bischof, O., K. Schwamborn, N. Martin, A. Werner, C. Sustmann, R. Grosschedl, and A. Dejean. 2006. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol. Cell 22:783-794.
8. Bode, A. M., and Z. Dong. 2004. Post-translational modification of p53 in tumorigenesis. Nat. Rev. Cancer 4:793-805.
9. Brown, J. L., D. Mucci, M. Whiteley, M. L. Dirksen, and J. A. Kassis. 1998. The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol. Cell 1:1057-1064.
10. Caretti, G., M. Di Padova, B. Micales, G. E. Lyons, and V. Sartorelli. 2004. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 18:2627-2638.
11. Chen, L., and J. Chen. 2003. MDM2-ARF complex regulates p53 sumoylation. Oncogene 22:5348-5357.
12. Furlong, E. E. M., T. Rein, and F. Martin. 1996. YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity. Mol. Cell. Biol. 16:5933-5945.
13. Garcia, E., C. Marcos-Gutierrez, M. del Mar Lorente, J. C. Moreno, and M. Vidal. 1999. RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1. EMBO J. 18:3404-3418.
14. Gill, G. 2005. Something about SUMO inhibits transcription. Curr. Opin. Genet. Dev. 15:536-541.
15. Gill, G. 2004. SUMO and ubiquitin in the nucleus: different functions, similar mechanisms? Genes Dev. 18:2046-2059.
16. Gordon, S., G. Akopyan, H. Garban, and B. Bonavida. 2006. Transcription factor YY1: structure, function, and therapeutic implications in cancer biology. Oncogene 25:1125-1142.
17. Gronroos, E., A. A. Terentiev, T. Punga, and J. Ericsson. 2004. YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc. Natl. Acad. Sci. USA 101:12165-12170.
18. Gross, M., R. Yang, I. Top, C. Gasper, and K. Shuai. 2004. PIASy-mediated repression of the androgen receptor is independent of sumoylation. Oncogene 23:3059-3066.
19. Hay, R. T. 2005. SUMO: a history of modification. Mol. Cell 18:1-12.
20. Hochstrasser, M. 2001. SP-RING for SUMO: new functions bloom for a ubiquitin-like protein. Cell 107:5-8.
21. Inouye, C. J., and E. Seto. 1994. Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B23. J. Biol. Chem. 269:6506-6510.
22. Ji, Z., C. Degerny, N. Vintonenko, J. Deheuninck, B. Foveau, C. Leroy, J. Coll, D. Tulasne, J. L. Baert, and V. Fafeur. 2007. Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation. Oncogene 26:395-406. (First published 24 July 2006; doi:10.1038/sj.onc.1209789.)
23. Johnson, E. S. 2004. Protein modification by SUMO. Annu. Rev. Biochem. 73:355-382.
24. Johnson, E. S., and A. A. Gupta. 2001. An E3-like factor that promotes SUMO conjugation to the yeast septins. Cell 106:735-744.
25. Kagey, M. H., T. A. Melhuish, S. E. Powers, and D. Wotton. 2005. Multiple activities contribute to Pc2 E3 function. EMBO J. 24:108-119.
26. Kagey, M. H., T. A. Melhuish, and D. Wotton. 2003. The polycomb protein Pc2 is a SUMO E3. Cell 113:127-137.
27. Kahyo, T., T. Nishida, and H. Yasuda. 2001. Involvement of PIAS1 in the sumoylation of tumor suppressor p53. Mol. Cell 8:713-718.
28. Kotaja, N., U. Karvonen, O. A. Jänne, and J. J. Palvimo. 2002. PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol. Cell. Biol. 22:5222-5234.
29. Kracklauer, M. P., and C. Schmidt. 2003. At the crossroads of SUMO and NF-kappaB. Mol. Cancer 2:39.
30. Kwek, S. S., J. Derry, A. L. Tyner, Z. Shen, and A. V. Gudkov. 2001. Functional analysis and intracellular localization of p53 modified by SUMO-1. Oncogene 20:2587-2599.
31. Last, T. J., A. J. van Wljnen, M. J. Birnbaum, G. S. Stein, and J. L. Stein. 1999. Multiple interactions of the transcription factor YY1 with human histone H4 gene regulatory elements. J. Cell Biochem. 72:507-516.
32. Lee, J. S., K. M. Galvin, R. H. See, R. Eckner, D. Livingston, E. Moran, and Y. Shi. 1995. Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 9:1188-1198.
33. Lee, T. C., Y. Zhang, and R. J. Schwartz. 1994. Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis. Oncogene 9:1047-1052.
34. Long, J., D. Zuo, and M. Park. 2005. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J. Biol. Chem. 280:35477-35489.
35. Lund, A. H., and M. van Lohuizen. 2004. Epigenetics and cancer. Genes Dev. 18:2315-2335.
36. Mabb, A. M., S. M. Wuerzberger-Davis, and S. Miyamoto. 2006. PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress. Nat. Cell Biol. 8:986-993.
37. Melchior, F. 2000. SUMO - nonclassical ubiquitin. Annu. Rev. Cell Dev. Biol. 16:591-626.
38. Melchior, F., M. Schergaut, and A. Pichler. 2003. SUMO: ligases, isopeptidases and nuclear pores. Trends Biochem. Sci. 28:612-618.
39. Minty, A., X. Dumont, M. Kaghad, and D. Caput. 2000. Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif. J. Biol. Chem. 275:36316-36323.
40. Miyauchi, Y., S. Yogosawa, R. Honda, T. Nishida, and H. Yasuda. 2002. Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes. J. Biol. Chem. 277:50131-50136.
41. Muller, S., C. Hoege, G. Pyrowolakis, and S. Jentsch. 2001. SUMO, ubiquitin's mysterious cousin. Nat. Rev. Mol. Cell. Biol. 2:202-210.
42. Nelson, V., G. E. Davis, and S. A. Maxwell. 2001. A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis. Apoptosis 6:221-234.
43. O'Carroll, D., S. Erhardt, M. Pagani, S. C. Barton, M. A. Surani, and T. Jenuwein. 2001. The Polycomb-group gene Ezh2 is required for early mouse development. Mol. Cell. Biol. 21:4330-4336.
44. Palko, L., H. W. Bass, M. J. Beyrouthy, and M. M. Hurt. 2004. The Yin Yang-1 (YY1) protein undergoes a DNA-replication-associated switch in localization from the cytoplasm to the nucleus at the onset of S phase. J. Cell Sci. 117:465-476.
45. Petkova, V., M. J. Romanowski, I. Sulijoadikusumo, D. Rohne, P. Kang, T. Shenk, and A. Usheva. 2001. Interaction between YY1 and the retinoblastoma protein. Regulation of cell cycle progression in differentiated cells. J. Biol. Chem. 276:7932-7936.
46. Pichler, A., A. Gast, J. S. Seeler, A. Dejean, and F. Melchior. 2002. The nucleoporin RanBP2 has SUMO1 E3 ligase activity. Cell 108:109-120.
47. Rezai-Zadeh, N., X. Zhang, F. Namour, G. Fejer, Y. D. Wen, Y. L. Yao, I. Gyory, K. Wright, and E. Seto. 2003. Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Genes Dev. 17:1019-1029.
48. Riggs, K. J., S. Saleque, K. K. Wong, K. T. Merrell, J. S. Lee, Y. Shi, and K. Calame. 1993. Yin-yang 1 activates the c-myc promoter. Mol. Cell. Biol. 13:7487-7495.
49. Rubinson, D. A., C. P. Dillon, A. V. Kwiatkowski, C. Sievers, L. Yang, J. Kopinja, D. L. Rooney, M. M. Ihrig, M. T. McManus, F. B. Gertler, M. L. Scott, and L. Van Parijs. 2003. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33:401-406.
50. Sachdev, S., L. Bruhn, H. Sieber, A. Pichler, F. Melchior, and R. Grosschedl. 2001. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev. 15:3088-3103.
51. Sacher, M., B. Pfander, C. Hoege, and S. Jentsch. 2006. Control of Rad52 recombination activity by double-strand break-induced SUMO modification. Nat. Cell Biol. 8:1284-1290.
52. Schlisio, S., T. Halperin, M. Vidal, and J. R. Nevins. 2002. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. EMBO J. 21:5775-5786.
53. Seto, E., B. Lewis, and T. Shenk. 1993. Interaction between transcription factors Sp1 and YY1. Nature 365:462-464.
54. Shi, Y., J. S. Lee, and K. M. Galvin. 1997. Everything you have ever wanted to know about Yin Yang 1 .... Biochim. Biophys. Acta 1332:F49-F66.
55. Shi, Y., E. Seto, L. S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GLI-Kruppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67:377-388.
56. Shrivastava, A., S. Saleque, G. V. Kalpana, S. Artandi, S. P. Goff, and K. Calame. 1993. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 262:1889-1892.
57. Srinivasan, L., and M. L. Atchison. 2004. YY1 DNA binding and PcG recruitment requires CtBP. Genes Dev. 18:2596-2601.
58. Sui, G., E. B. Affar, Y. Shi, C. Brignone, N. R. Wall, P. Yin, M. Donohoe, M. P. Luke, D. Calvo, S. R. Grossman, and Y. Shi. 2004. Yin Yang 1 is a negative regulator of p53. Cell 117:859-872.
59. Sui, G., and Y. Shi. 2005. Gene silencing by a DNA vector-based RNAi technology. Methods Mol. Biol. 309:205-218.
60. Takahashi, Y., T. Kahyo, E. A. Toh, H. Yasuda, and Y. Kikuchi. 2001. Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates. J. Biol. Chem. 276:48973-48977.
61. Takahashi, Y., A. Toh-e, and Y. Kikuchi. 2001. A novel factor required for the SUMO1/Smt3 conjugation of yeast septins. Gene 275:223-231.
62. Thomas, M. J., and E. Seto. 1999. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene 236:197-208.
63. Usheva, A., and T. Shenk. 1996. YY1 transcriptional initiator: protein interactions and association with a DNA site containing unpaired strands. Proc. Natl. Acad. Sci. USA 93:13571-13576.
64. Wang, L., J. L. Brown, R. Cao, Y. Zhang, J. A. Kassis, and R. S. Jones. 2004. Hierarchical recruitment of polycomb group silencing complexes. Mol. Cell 14:637-646.
65. Wu, F., and A. S. Lee. 2001. YY1 as a regulator of replication-dependent hamster histone H3.2 promoter and an interactive partner of AP-2. J. Biol. Chem. 276:28-34.
66. Yang, W. M., Y. L. Yao, J. M. Sun, J. R. Davie, and E. Seto. 1997. Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J. Biol. Chem. 272:28001-28007.
67. Yao, Y.-L., W.-M. Yang, and E. Seto. 2001. Regulation of transcription factor YY1 by acetylation and deacetylation. Mol. Cell. Biol. 21:5979-5991.
68. 243 disrupts the ATF/CREB-YY1 complex at the mouse c-fos promoter. J. Virol. 69:7402-7409.
69. Zhou, Q., R. W. Gedrich, and D. A. Engel. 1995. Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB. J. Virol. 69:4323-4330.