Synthesis and cytotoxic activity of dimeric analogs of acronycine in the benzo[b]pyrano[3,2-h]acridin-7-one series

Chemical and Pharmaceutical Bulletin

Volumn 55, Issue 5, 2007, Pages 734-738

  Gaslonde, Thomas ^a   Michel, Sylvie ^a   Koch, Michel ^a   Pfeiffer, Bruno ^b   Léonce, Stéphane ^b   Pierré, Alain ^b   Tillequin, François ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Acronycine; Benzo b pyrano 3,2 h acridin 7 one dimer; Cytotoxicity; Synthesis

Indexed keywords

1,4 DIIODOBUTANE; 5 (PROP 2 ENYL) 6 (PROP 2 ENYLOXY) 3,3,14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 (3 IODOPROPYLOXY) 3,3,14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 (4 IODOBUTYLOXY) 3,3 14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 (5 IODOPENTYLOXY) 3,3,14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 (6 IODOHEXYLOXY) 3,3 14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 (PROP 2 ENYLOXY) 3,3,14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 HYDROXY 3,3 14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 HYDROXY 5 (6 IODOHEXYLOXY) 3,3,14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 HYDROXY 5 (PENT 4 ENYL) 3,3,14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6 HYDROXY 5 (PROP 2 ENYL) 3,3,14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; 6,6' (BUTANE 1,4 DIYLBISOXY)BIS(3,3 14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE); 6,6' (HEXANE 1,6 DIYLBISOXY)BIS(3,3 14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE); 6,6' (PENTANE 1,5 DIYLBISOXY)BIS(3,3 14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE); 6,6' (PROPANE 1,3 DIYLBISOXY)BIS(3,3 14 TRIMETHYL 3,14 DIHYDRO 7H BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE); 6,6,9 TRIMETHYL 3,4,6,9 TETRAHYDRO 2H,16H BENZO[I]DIPYRANO[2,3-A:2',3'-C]ACRIDIN 16 ONE; 7,7,10 TRIMETHYL 2,3,4,5,7,10 HEXAHYDRO 17H BENZO[I]OXEPINO[2,3-A]PYRANO[2,3-C]ACRIDIN 17 ONE; 8,8,11 TRIMETHYL 3,4,5,6,8,11 2H,18H BENZO[I]OXOCINO[2,3-A]PYRANO[2,3-C]ACRIDIN 18 ONE; ACRONINE; ALKANE DERIVATIVE; ALPHA,OMEGA DIIODOALKANE DERIVATIVE; BENZO[B]ACRONYCINE; BENZO[B]PYRANO[3,2-H]ACRIDIN 7 ONE; BENZOPYRANOACRIDONE; BUTANE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CHEMICAL REACTION; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MOUSE; NONHUMAN;

ACRONINE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE; CELL PROLIFERATION; FLOW CYTOMETRY; INDICATORS AND REAGENTS; LEUKEMIA L1210; MAGNETIC RESONANCE SPECTROSCOPY; MICE; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34248202039     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.55.734     Document Type: Article

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