New mechanism for an old drug: Aspirin triggers anti-inflammatory lipid mediators with gender implications

Comprehensive Therapy

Volumn 32, Issue 3, 2006, Pages 150-157

  Chiang, Nan ^a   Serhan, Charles N ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DOCOSAHEXAENOIC ACID; FATTY ACID DERIVATIVE; ICOSAPENTAENOIC ACID; LIPOXIN A; NONSTEROID ANTIINFLAMMATORY AGENT; OMEGA 3 FATTY ACID;

ACETYLATION; AGE DISTRIBUTION; ALZHEIMER DISEASE; ARTICLE; ASTHMA; BLOOD VESSEL OCCLUSION; BREAST CANCER; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COLITIS; COLON CANCER; CYSTIC FIBROSIS; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; GLOMERULONEPHRITIS; HEART INFARCTION; HUMAN; INFLAMMATION; LOW DRUG DOSE; LUNG CANCER; NONHUMAN; PERIODONTITIS; PERITONITIS; REPERFUSION INJURY; RETINA INJURY; SEX DIFFERENCE; SKIN INFLAMMATION; STROKE;

ACETYLATION; ASPIRIN; CYCLOOXYGENASE INHIBITORS; HUMANS; LIPOXINS; NEUTROPHILS; RANDOMIZED CONTROLLED TRIALS; SEX FACTORS; THROMBOXANE B2;

EID: 34248196011     PISSN: 00988243     EISSN: None     Source Type: Journal    
DOI: 10.1385/COMP:32:3:150     Document Type: Article

References (37)

1. Samuelsson B. From studies of biochemical mechanisms to novel biological mediators: prostaglandin endoperoxides, thromboxanes and leukotrienes. In: Les Prix Nobel: Nobel Prizes, Presentations, Biographies and Lectures (Odelberg W., ed.). Almqvist & Wiksell, Stockholm, Sweden, 1982, pp. 153-174.
2. Vane JR. Adventures and excursions in bioassay: the stepping stones to prostacyclin. In: Les Prix Nobel: Nobel Prizes, Presentations, Biographies and Lectures (Odelberg W., ed.). Almqvist & Wiksell, Stockholm, Sweden, 1982, pp. 181-206.
3. Needleman P, Isakson PC. The discovery and function of COX-2. J Rheumatol 1997;49(Suppl):6-8.
4. Marcus AJ, Broekman MJ, Pinsky DJ. COX inhibitors and thromboregulation. N Engl J Med 2002;347:1025-1026.
5. Flower, R. What are all the things that aspirin does? BMJ 2003;327:572-573.
6. Claria J, Serhan CN. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci USA. 1995;92:9475-9479.
7. Serhan CN. The lipoxins and the aspirin triggered lipoxins. Prostaglandins Leukot Essent Fatty Acids. 2005;73(special issue).
8. Serhan CN, Gotlinger K, Hong S, Arita M. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. Prostaglandins Other Lipid Mediat 2004;73:155-172.
9. Canny G, Levy O, Furuta GT, et al. Lipid mediator-induced expression of bactericidal/permeability-increasing protein (BPI) in human mucosal epithelia. Proc Natl Acad Sci USA 2002;99:3902-3907.
10. Leaf A, Xiao YF, Kang JX, Billman GE. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Pharmacol Ther 2003;98:355-377.
11. Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN. Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci USA 2004;101:15,178-15,183.
12. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 1994;308:81-106.
13. 4 formation: A randomized human trial. Arterioscler Thromb Vasc Biol 2006;26:e14-17.
14. Ridker PM, Cook NR, Lee IM, et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med 2005;352:1293-1304.
15. Topper JN, Cai J, Falb D, Gimbrone MA Jr. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 1996;93:10,417-10,422.
16. Fiorucci S, Wallace JL, Mencarelli A, et al. A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction. Proc Natl Acad Sci USA 2004;101:15,736-15,741.
17. Cheng Y, Austin SC, Rocca B, et al. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 2002;296:539-541.
18. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med 2000;192:1197-1204.
19. Serhan CN, Hong S, Gronert K, et al. Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter pro-inflammation signals. J Exp Med 2002;196:1025-1037.
20. Fiorucci S, Distrutti E, De Lima OM, et al. Relative contribution of acetylated cyclooxygenase (COX)-2 and 5-lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin. FASEB J 2003;17:1171-1173.
21. 4 receptor that is conserved in structure and function. Br J Pharmacol 2003;139:89-98.
22. Gewirtz AT, Collier-Hyams LS, Young AN, et al. Lipoxin A4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. J Immunol 2002;168:5260-5267.
23. 4 stable analogues. J Clin Invest 1998;101:819-826.
24. 4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest 1999;104:309-316.
25. Scalia R, Gefen J, Petasis NA, Serhan CN, Lefer AM. Lipoxin A4 stable analogs inhibit leukocyte rolling and adherence in the rat mesenteric microvasculature: role of P-selectin. Proc Natl Acad Sci USA 1997;94:9967-9972.
26. Levy BD, De Sanctis GT, Devchand PR, et al. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med 2002;8:1018-1023.
27. Karp CL, Flick LM, Park KW, et al. Defective lipoxin-mediated anti-inflammatory activity in the cystic fibrosis airway. Nat Immunol 2004;5:388-392.
28. Fierro IM, Kutok JL, Serhan CN. Novel lipid mediator regulators of endothelial cell proliferation and migration: aspirin-triggered-15R-lipoxin A(4) and lipoxin A(4). J Pharmacol Exp Ther 2002;300:385-392.
29. Serhan CN, Jain A, Marleau S, et al. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol 2003;171:6856-6865.
30. Gronert K, Maheshwari N, Khan N, et al. A role for the mouse 12/15-lipoxygenase pathway in promoting epithelial wound healing and host defense. J Biol Chem 2005;280:15,267-15,278.
31. Devchand PR, Schmidt BA, Primo VC, et al. A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J 2005;19:203-210.
32. Arita M, Yoshida M, Hong S, et al. Resolvin E1, a novel endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against TNBS-induced colitis. Proc Natl Acad Sci USA 2005;102:7671-7676.
33. Hasturk H, Kantarci A, Ohira T, et al. RvE1 protects from local inflammation and osteoclast mediated bone destruction in periodontitis. FASEB J. 2006;20:401-403.
34. Hong S, Gronert K, Devchand P, Moussignac R-L, Serhan CN. Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood and glial cells: autacoids in anti-inflammation. J Biol Chem 2003;278:14,677-14,687.
35. Marcheselli VL, Hong S, Lukiw WJ, et al. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 2003;278:43,807-43,817.
36. Mukherjee PK, Marcheselli VL, Serhan CN, Bazan NG. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. Proc Natl Acad Sci USA 2004;101:8491-8496.
37. Lukiw WJ, Cui JG, Marcheselli VL, et al. A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 2005;115:2774-2783.