Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors

Journal of Medicinal Chemistry

Volumn 42, Issue 6, 1999, Pages 1041-1052

  Belyaev, Alexander ^a   Zhang, Xuemei ^a   Augustyns, Koen ^a   Lambeir, Anne Marie ^a   De Meester, Ingrid ^a   Vedernikova, Irina ^a   Scharpé, Simon ^a   Haemers, Achiel ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(4 ACETAMIDOPHENYL) 1 PROLYLPYRROLIDINE 2 PHOSPHONATE; DIPEPTIDYL PEPTIDASE IV; PHOSPHONIC ACID ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CYTOTOXICITY; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; RABBIT; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; DIPEPTIDYL PEPTIDASES; DRUG STABILITY; ENZYME INHIBITORS; HUMANS; KINETICS; LEUKOCYTES, MONONUCLEAR; MALE; MICE; PHOSPHONIC ACIDS; PROLINE; RABBITS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033602521     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm981033g     Document Type: Article

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