Monitoring repair of DNA damage in cell lines and human peripheral blood mononuclear cells

Analytical Biochemistry

Volumn 365, Issue 2, 2007, Pages 246-259

  Lee, Hyun Wook ^a   Lee, Hae Jung ^a   Hong, Chong mu ^a   Baker, David J ^a   Bhatia, Ravi ^a   O'Connor, Timothy R ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

8 Oxoguanine; DNA damage; Oxidative damage; siRNA; Strand specific repair

Indexed keywords

BLOOD; CELL CULTURE; CELLS; DNA; POLYMERASE CHAIN REACTION;

8-OXOGUANINE; DNA DAMAGES; HUMAN PERIPHERAL BLOOD; OXIDATIVE DAMAGE; QUANTITATIVE REAL TIME PCR; REAL-TIME PCR METHOD; SIRNA; SMALL INTERFERING RNA;

MOLECULAR BIOLOGY;

7,8 DIHYDRO 8 OXOGUANINE DNA GLYCOSYLASE; 8 HYDROXYGUANINE; DNA; DNA GLYCOSYLTRANSFERASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIOPHAGE; CELL LINE; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOWN REGULATION; EXON; GENETIC TRANSFECTION; HALF LIFE TIME; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY;

EID: 34247884259     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2007.03.016     Document Type: Article

References (83)

1. Barnes D.E., and Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu. Rev. Genet. 38 (2004) 445-476
2. Collins A.R. Assays for oxidative stress and antioxidant status: Applications to research into the biological effectiveness of polyphenols. Am. J. Clin. Nutr. 81 (2005) 261S-267S
3. De Bont R., and van Larebeke N. Endogenous DNA damage in humans: A review of quantitative data. Mutagenesis 19 (2004) 169-185
4. Friedberg E.C., McDaniel L.D., and Schultz R.A. The role of endogenous and exogenous DNA damage and mutagenesis. Curr. Opin. Genet. Dev. 14 (2004) 5-10
5. Nishimura S. Involvement of mammalian OGG1(MMH) in excision of the 8-hydroxyguanine residue in DNA. Free Radic. Biol. Med. 32 (2002) 813-821
6. Termini J. Hydroperoxide-induced DNA damage and mutations. Mutat. Res. 450 (2000) 107-124
7. Wogan G.N., Hecht S.S., Felton J.S., Conney A.H., and Loeb L.A. Environmental and chemical carcinogenesis. Semin. Cancer Biol. 14 (2004) 473-486
8. Sekiguchi M., and Tsuzuki T. Oxidative nucleotide damage: Consequences and prevention. Oncogene 21 (2002) 8895-8904
9. Schneider J.E., Price S., Maidt L., Gutteridge J.M., and Floyd R.A. Methylene blue plus light mediates 8-hydroxy 2′-deoxyguanosine formation in DNA preferentially over strand breakage. Nucleic Acids Res. 18 (1990) 631-635
10. Schneider Jr. J.E., Phillips J.R., Pye Q., Maidt M.L., Price S., and Floyd R.A. Methylene blue and rose bengal photoinactivation of RNA bacteriophages: Comparative studies of 8-oxoguanine formation in isolated RNA. Arch. Biochem. Biophys. 301 (1993) 91-97
11. Wood M.L., Esteve A., Morningstar M.L., Kuziemko G.M., and Essigmann J.M. Genetic effects of oxidative DNA damage: Comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli. Nucleic Acids Res. 20 (1992) 6023-6032
12. Kamiya H., Murata-Kamiya N., Koizume S., Inoue H., Nishimura S., and Ohtsuka E. 8-Hydroxyguanine (7,8-dihydro-8-oxoguanine) in hot spots of the c-Ha-ras gene: Effects of sequence contexts on mutation spectra. Carcinogenesis 16 (1995) 883-889
13. Thomas D., Scot A.D., Barbey R., Padula M., and Boiteux S. Inactivation of OGG1 increases the incidence of G. C → T.A transversions in Saccharomyces cerevisiae: Evidence for endogenous oxidative damage to DNA in eukaryotic cells. Mol. Gen. Genet. 254 (1997) 171-178
14. Ichinose T., Nobuyuki S., Takano H., Abe M., Sadakane K., Yanagisawa R., Ochi H., Fujioka K., Lee K.G., and Shibamoto T. Liver carcinogenesis and formation of 8-hydroxy-deoxyguanosine in C3H/HeN mice by oxidized dietary oils containing carcinogenic dicarbonyl compounds. Food Chem. Toxicol. 42 (2004) 1795-1803
15. Russo M.T., De Luca G., Degan P., Parlanti E., Dogliotti E., Barnes D.E., Lindahl T., Yang H., Miller J.H., and Bignami M. Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases. Cancer Res. 64 (2004) 4411-4414
16. Xie Y., Yang H., Cunanan C., Okamoto K., Shibata D., Pan J., Barnes D.E., Lindahl T., McIlhatton M., Fishel R., and Miller J.H. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res. 64 (2004) 3096-3102
17. Nakabeppu Y., Tsuchimoto D., Ichinoe A., Ohno M., Ide Y., Hirano S., Yoshimura D., Tominaga Y., Furuichi M., and Sakumi K. Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: From mitochondria to nuclei. Ann. N.Y. Acad. Sci. 1011 (2004) 101-111
18. Arai T., Kelly V.P., Komoro K., Minowa O., Noda T., and Nishimura S. Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA. Cancer Res. 63 (2003) 4287-4292
19. Sakumi K., Tominaga Y., Furuichi M., Xu P., Tsuzuki T., Sekiguchi M., and Nakabeppu Y. Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. Cancer Res. 63 (2003) 902-905
20. Dizdaroglu M., Jaruga P., Birincioglu M., and Rodriguez H. Free radical-induced damage to DNA: Mechanisms and measurement. Free Radic. Biol. Med. 32 (2002) 1102-1115
21. Gackowski D., Speina E., Zielinska M., Kowalewski J., Rozalski R., Siomek A., Paciorek T., Tudek B., and Olinski R. Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer. Cancer Res. 63 (2003) 4899-4902
22. Paz-Elizur T., Krupsky M., Blumenstein S., Elinger D., Schechtman E., and Livneh Z. DNA repair activity for oxidative damage and risk of lung cancer. J. Natl. Cancer Inst. 95 (2003) 1312-1319
23. Sancar A., Lindsey-Boltz L.A., Unsal-Kacmaz K., and Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73 (2004) 39-85
24. Scharer O.D. Chemistry and biology of DNA repair. Angew. Chem. Intl. Ed. 42 (2003) 2946-2974
25. Lu R., Nash H.M., and Verdine G.L. A mammalian DNA repair enzyme that excises oxidatively damaged guanine maps to a locus frequently lost in lung cancer. Curr. Biol. 7 (1997) 397-407
26. Roldan-Arjona T., Wei Y.F., Carter K.C., Klungland A., Anselmino C., Wang R.P., Augustus M., and Lindahl T. Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase. Proc. Natl. Acad. Sci. USA 94 (1997) 8016-8020
27. Radicella J.P., Dherin C., Desmaze C., Fox M.S., and Boiteux S. Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 94 (1997) 8010-8015
28. Rosenquist T.A., Zharkov D.O., and Grollman A.P. Cloning and characterization of a mammalian 8-oxoguanine DNA glycosylase. Proc. Natl. Acad. Sci. USA 94 (1997) 7429-7434
29. Hazra T.K., Izumi T., Boldogh I., Imhoff B., Kow Y.W., Jaruga P., Dizdaroglu M., and Mitra S. Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA. Proc. Natl. Acad. Sci. USA 99 (2002) 3523-3528
30. Osterod M., Larsen E., Le Page F., Hengstler J.G., Van der Horst G.T., Boiteux S., Klungland A., and Epe B. A global DNA repair mechanism involving the Cockayne syndrome B (CSB) gene product can prevent the in vivo accumulation of endogenous oxidative DNA base damage. Oncogene 21 (2002) 8232-8239
31. Fromme J.C., Bruner S.D., Yang W., Karplus M., and Verdine G.L. Product-assisted catalysis in base-excision DNA repair. Nat. Struct. Biol. 10 (2003) 204-211
32. Dianov G., Bischoff C., Piotrowski J., and Bohr V.A. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts. J. Biol. Chem. 273 (1998) 33811-33816
33. Hazra T.K., Izumi T., Maidt L., Floyd R.A., and Mitra S. The presence of two distinct 8-oxoguanine repair enzymes in human cells: Their potential complementary roles in preventing mutation. Nucleic Acids Res. 26 (1998) 5116-5122
34. Rosenquist T.A., Zaika E., Fernandes A.S., Zharkov D.O., Miller H., and Grollman A.P. The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. DNA Repair (Amst.) 2 (2003) 581-591
35. Inoue M., Shen G.P., Chaudhry M.A., Galick H., Blaisdell J.O., and Wallace S.S. Expression of the oxidative base excision repair enzymes is not induced in TK6 human lymphoblastoid cells after low doses of ionizing radiation. Radiat. Res. 161 (2004) 409-417
36. Zhang Q.M., Yonekura S., Takao M., Yasui A., Sugiyama H., and Yonei S. DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells. DNA Repair (Amst.) 4 (2005) 71-79
37. Le Page F., Klungland A., Barnes D.E., Sarasin A., and Boiteux S. Transcription coupled repair of 8-oxoguanine in murine cells: The ogg1 protein is required for repair in nontranscribed sequences but not in transcribed sequences. Proc. Natl. Acad. Sci. USA 97 (2000) 8397-8402
38. Le Page F., Randrianarison V., Marot D., Cabannes J., Perricaudet M., Feunteun J., and Sarasin A. BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells. Cancer Res. 60 (2000) 5548-5552
39. Reardon J.T., Bessho T., Kung H.C., Bolton P.H., and Sancar A. In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in xeroderma pigmentosum patients. Proc. Natl. Acad. Sci. USA 94 (1997) 9463-9468
40. Ni T.T., Marsischky G.T., and Kolodner R.D. MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae. Mol. Cell 4 (1999) 439-444
41. Wyrzykowski J., and Volkert M.R. The Escherichia coli methyl-directed mismatch repair system repairs base pairs containing oxidative lesions. J. Bacteriol. 185 (2003) 1701-1704
42. Evans M.D., Dizdaroglu M., and Cooke M.S. Oxidative DNA damage and disease: Induction, repair, and significance. Mutat. Res. 567 (2004) 1-61
43. Zastawny T.H., Altman S.A., Randers-Eichhorn L., Madurawe R., Lumpkin J.A., Dizdaroglu M., and Rao G. DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions. Free Radic. Biol. Med. 18 (1995) 1013-1022
44. Halliwell B., and Dizdaroglu M. The measurement of oxidative damage to DNA by HPLC and GC/MS techniques. Free Radic. Res. Commun. 16 (1992) 75-87
45. Ayala-Torres S., Chen Y., Svoboda T., Rosenblatt J., and Van Houten B. Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction. Methods 22 (2000) 135-147
46. Grimaldi K.A., Bingham J.P., and Hartley J.A. PCR-based assays for strand-specific measurement of DNA damage and repair: I. Strand-specific quantitative PCR. Methods Mol. Biol. 113 (1999) 227-240
47. Phoa N., and Epe B. Influence of nitric oxide on the generation and repair of oxidative DNA damage in mammalian cells. Carcinogenesis 23 (2002) 469-475
48. Klungland A., Rosewell I., Hollenbach S., Larsen E., Daly G., Epe B., Seeberg E., Lindahl T., and Barnes D.E. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. Proc. Natl. Acad. Sci. USA 96 (1999) 13300-13305
49. Osterod M., Hollenbach S., Hengstler J.G., Barnes D.E., Lindahl T., and Epe B. Age-related and tissue-specific accumulation of oxidative DNA base damage in 7,8-dihydro-8-oxoguanine-DNA glycosylase (Ogg1) deficient mice. Carcinogenesis 22 (2001) 1459-1463
50. Nishimura S. Mammalian Ogg1/Mmh gene plays a major role in repair of the 8-hydroxyguanine lesion in DNA. Prog. Nucleic Acid Res. Mol. Biol. 68 (2001) 107-123
51. Jensen A., Calvayrac G., Karahalil B., Bohr V.A., and Stevnsner T. Mammalian 8-oxoguanine DNA glycosylase 1 incises 8-oxoadenine opposite cytosine in nuclei and mitochondria, while a different glycosylase incises 8-oxoadenine opposite guanine in nuclei. J. Biol. Chem. 278 (2003) 19541-19548
52. Imai K., Nakata K., Kawai K., Hamano T., Mei N., Kasai H., and Okamoto T. Induction of 8-oxoguanine DNA glycosylase 1 gene expression by HIV-1 Tat. J. Biol. Chem. 280 (2005) 21673-21679
53. Jeong H.G., Youn C.K., Cho H.J., Kim S.H., Kim M.H., Kim H.B., Chang I.Y., Lee Y.S., Chung M.H., and You H.J. Metallothionein-III prevents gamma-ray-induced 8-oxoguanine accumulation in normal and hOGG1-depleted cells. J. Biol. Chem. 279 (2004) 34138-34149
54. Lu T., Pan Y., Kao S.Y., Li C., Kohane I., Chan J., and Yankner B.A. Gene regulation and DNA damage in the ageing human brain. Nature 429 (2004) 883-891
55. Paz-Elizur T., Elinger D., Leitner-Dagan Y., Blumenstein S., Krupsky M., Berrebi A., Schechtman E., and Livneh Z. Development of an enzymatic DNA repair assay for molecular epidemiology studies: Distribution of OGG activity in healthy individuals. DNA Repair (Amst.) 6 (2007) 45-60
56. Ramos J.M., Ruiz A., Colen R., Lopez I.D., Grossman L., and Matta J.L. DNA repair and breast carcinoma susceptibility in women. Cancer 100 (2004) 1352-1357
57. Johnson J.M., and Latimer J.J. Analysis of DNA repair using transfection-based host cell reactivation. Methods Mol. Biol. 291 (2005) 321-335
58. Hu W., Feng Z., and Tang M.S. Chromium(VI) enhances (±)-anti-7β,8α-dihydroxy-9α,10α-epoxy-7,8, 9,10-tetrahydro benzo[a]pyrene-induced cytotoxicity and mutagenicity in mammalian cells through its inhibitory effect on nucleotide excision repair. Biochemistry 43 (2004) 14282-14289
59. Vogel U., Dybdahl M., Frentz G., and Nexo B.A. DNA repair capacity: Inconsistency between effect of over-expression of five NER genes and the correlation to mRNA levels in primary lymphocytes. Mutat. Res. 461 (2000) 197-210
60. Hallberg L.M., Bechtold W.E., Grady J., Legator M.S., and Au W.W. Abnormal DNA repair activities in lymphocytes of workers exposed to 1,3-butadiene. Mutat. Res. 383 (1997) 213-221
61. McKay B.C., and Rainbow A.J. Heat-shock enhanced reactivation of a UV-damaged reporter gene in human cells involves the transcription coupled DNA repair pathway. Mutat. Res. 363 (1996) 125-135
62. Wei Q., Matanoski G.M., Farmer E.R., Hedayati M.A., and Grossman L. DNA repair related to multiple skin cancers and drug use. Cancer Res. 54 (1994) 437-440
63. Hall J., English D.R., Artuso M., Armstrong B.K., and Winter M. DNA repair capacity as a risk factor for non-melanocytic skin cancer: A molecular epidemiological study. Intl. J. Cancer 58 (1994) 179-184
64. Protic-Sabljic M., and Kraemer K.H. Host cell reactivation by human cells of DNA expression vectors damaged by ultraviolet radiation or by acid-heat treatment. Carcinogenesis 7 (1986) 1765-1770
65. Sun Y., and Moses R.E. Reactivation of psoralen-reacted plasmid DNA in Fanconi anemia, xeroderma pigmentosum, and normal human fibroblast cells. Somat. Cell. Mol. Genet. 17 (1991) 229-238
66. Athas W.F., Hedayati M.A., Matanoski G.M., Farmer E.R., and Grossman L. Development and field-test validation of an assay for DNA repair in circulating human lymphocytes. Cancer Res. 51 (1991) 5786-5793
67. Loechler E.L., Green C.L., and Essigmann J.M. In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome. Proc. Natl. Acad. Sci. USA 81 (1984) 6271-6275
68. Gentil A., Renault G., Madzak C., Margot A., Cabral-Neto J.B., Vasseur J.J., Rayner B., Imbach J.L., and Sarasin A. Mutagenic properties of a unique abasic site in mammalian cells. Biochem. Biophys. Res. Commun. 173 (1990) 704-710
69. Moriya M., Ou C., Bodepudi V., Johnson F., Takeshita M., and Grollman A.P. Site-specific mutagenesis using a gapped duplex vector: A study of translesion synthesis past 8-oxodeoxyguanosine in E. coli. Mutat. Res. 254 (1991) 281-288
70. Le Page F., Margot A., Grollman A.P., Sarasin A., and Gentil A. Mutagenicity of a unique 8-oxoguanine in a human Ha-ras sequence in mammalian cells. Carcinogenesis 16 (1995) 2779-2784
71. Koehl P., Burnouf D., and Fuchs R.P. Construction of plasmids containing a unique acetylaminofluorene adduct located within a mutation hot spot: A new probe for frameshift mutagenesis. J. Mol. Biol. 207 (1989) 355-364
72. Burnouf D., Koehl P., and Fuchs R.P. Single adduct mutagenesis: Strong effect of the position of a single acetylaminofluorene adduct within a mutation hot spot. Proc. Natl. Acad. Sci. USA 86 (1989) 4147-4151
73. Wagner J., Kamiya H., and Fuchs R.P. Leading versus lagging strand mutagenesis induced by 7,8-dihydro-8-oxo-2′-deoxyguanosine in Escherichia coli. J. Mol. Biol. 265 (1997) 302-309
74. Boiteux S., and Le Page F. Repair of 8-oxoguanine and Ogg1-incised apurinic sites in a CHO cell line. Prog. Nucleic Acid Res. Mol. Biol. 68 (2001) 95-105
75. O'Connor T.R. The use of DNA glycosylases to detect DNA damage. In: Pfeifer G.P. (Ed). Technologies for Detection of DNA Damage and Mutations (1996), Plenum, New York 155-170
76. Boiteux S., O'Connor T.R., Lederer F., Gouyette A., and Laval J. Homogeneous Escherichia coli FPG protein: A DNA glycosylase which excises imidazole ring-opened purines and nicks DNA at apurinic/apyrimidinic sites. J. Biol. Chem. 265 (1990) 3916-3922
77. O'Connor T.R., and Laval J. Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites. Proc. Natl. Acad. Sci. USA 86 (1989) 5222-5226
78. Yang G., Wang J., and Konigsberg W. Base selectivity is impaired by mutants that perturb hydrogen bonding networks in the RB69 DNA polymerase active site. Biochemistry 44 (2005) 3338-3346
79. Wang J., Sattar A.K., Wang C.C., Karam J.D., Konigsberg W.H., and Steitz T.A. Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69. Cell 89 (1997) 1087-1099
80. Karam J.D., and Konigsberg W.H. DNA polymerase of the T4-related bacteriophages. Prog. Nucleic Acid Res. Mol. Biol. 64 (2000) 65-96
81. Sambrook J., and Russell D.W. Molecular Cloning: A Laboratory Manual (2001), Cold Spring Harbor Press, Cold Spring Harbor, NY
82. Ye N., Holmquist G.P., and O'Connor T.R. Heterogeneous repair of N-methylpurines at the nucleotide level in normal human cells. J. Mol. Biol. 284 (1998) 269-285
83. Stary A., Menck C.F., and Sarasin A. Description of a new amplifiable shuttle vector for mutagenesis studies in human cells: Application to N-methyl-N′-nitro-N-nitrosoguanidine-induced mutation spectrum. Mutat. Res. 272 (1992) 101-110