3D computation modelling of the influence of cytokine secretion on Th-cell development suggests that negative selection (inhibition of Th1 cells) is more effective than positive selection by IL-4 for Th2 cell dominance

Immunology and Cell Biology

Volumn 85, Issue 3, 2007, Pages 189-196

  Jansson, Andreas ^a,b   Harlen, Mikael ^b   Karlsson, Stefan ^b   Nilsson, Patric ^b   Cooley, Margaret ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SKÖVDE   (Sweden)

Author keywords

Differentiation; Diffusion; IL 4; Simulation

Indexed keywords

INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; CYTOKINE RELEASE; MATHEMATICAL MODEL; SIMULATION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

ANIMALS; AUTOCRINE COMMUNICATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; KINETICS; MODELS, IMMUNOLOGICAL; RECEPTORS, INTERLEUKIN-4; TH1 CELLS; TH2 CELLS;

EID: 34247868910     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/sj.icb.7100023     Document Type: Article

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