Affinity regulates spatial range of EGF receptor autocrine ligand binding

Developmental Biology

Volumn 250, Issue 2, 2002, Pages 305-316

  DeWitt, Ann ^a   Iida, Tomoko ^a   Lam, Ho Yan ^a   Hill, Virginia ^c   Wiley, H Steven ^d   Lauffenburger, Douglas A ^a,b  

^a Center for Cancer Research   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; LIGAND;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BINDING AFFINITY; BIOLOGY; CELL FUNCTION; CELL LINE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EXPERIMENTAL MODEL; LIGAND BINDING; MODEL; MOLECULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; WILD TYPE;

EID: 0036402459     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0012-1606(02)90807-9     Document Type: Article

References (61)

1. Adam, R., Drummond, D. R., Solic, N., Holt, S. J., Sharma, R. P., Chamberlin, S. G., and Davies, D. E. (1995). Modulation of the receptor-binding affinity of amphiregulin by modification of its carboxyl-terminal tail. Biochim. Biophys. Acta 1266, 83-90.
2. Baonza, A., Casci, T., and Freeman, M. (2001). A primary role for the EGF receptor in ommatidial spacing in the Drosophila eye. Curr. Biol. 11, 398-404.
3. Bersgmann, A., Tugentman, M., Shilo, B. Z., and Steller, H. (2002). Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling. Dev. Cell 2, 159-170.
4. Bier, E. (1998). Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays 20, 189-194.
5. Casci, T., and Freeman, M. (1999). Control of EGF receptor signalling: Lessons from fruitflies. Cancer Metastasis Rev. 18, 181-201.
6. Chang, C., Newman, A. P., and Sternberg, P. W. (1999). Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia. Curr. Biol. 9, 237-246.
7. Chu, L., Wiley, H. S., and Lauffenburger, D. A. (1996). Endocytic relay as a potential means for enhancing ligand transport through cellular tissue matrices. Tissue Eng. 2, 17-38.
8. Chung, E. K., and Coffey, R. J. (2000). Multiple forms of secreted amphiregulin exhibit differential EGF receptor binding. Mol. Biol. Cell 11, 146.
9. Chung, Y. H., Kim, J. A., Song, B. C., Lee, G. C., Koh, M. S., Lee, Y. S., Lee, S. G., and Suh, D. J. (2000). Expression of TGFα mRNA in livers of patients with chronic viral hepatitis and hepatocellular carcinoma. Cancer 89, 977-982.
10. Derynck, R. (1992). The physiology of TGFα. Adv. Cancer Res. 5, 27-53.
11. DeWitt, A. E., Dong, J. Y., Wiley, H. S., and Lauffenburger, D. A. (2001). Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture. J. Cell Sci. 114, 2301-2313.
12. Forsten, K. E., and Lauffenburger, D. A. (1994). Probability of autocrine ligand capture by cell-surface receptors: Implications for ligand secretion measuremetns. J. Comp. Biol. 1, 15-23.
13. Freeman, M. (1996). Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87, 651-660.
14. Freeman, M. (1997). Cell determination strategies in the Drosophila eye. Development 124, 261-270.
15. Freeman, M. (2000). Feedback control of intercellular signalling in development. Nature 408, 313-319.
16. French, A. R., and Lauffenburger, D. A. (1997). Controlling receptor/ligand trafficking: Effects of cellular and molecular properties on endosomal sorting. Ann. Biomed. Eng. 25, 690-707.
17. French, A. R., Tadaki, D. K., Niyogi, S. K., and Lauffenburger, D. A. (1995). Intracellular trafficking of EGF family ligands is directly influenced by the pH sensitivity of the receptor-ligand interaction. J. Biol. Chem. 270, 4334-4340.
18. Gabay, L., Seger, R., and Shilo, B. Z. (1997). In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277, 1103-1106.
19. Gibson, A. E., Noel, R. J., Herlihy, J. T., and Ward, W. F. (1989). Phenylarsine oxide inhibition of endocytosis: Effects on asialofetuin internalization. Am. J. Physiol. 257, C182-C184.
20. Golembo, M., Raz, E., and Shilo, B. Z. (1996). The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122, 3363-3370.
21. Herrington, E. E., Ram, T. G., Salomon, D. S., Johnson, G. R., Gullick, W. J., Kenney, N., and Hosick, H. L. (1997). Expression of EGF-related proteins in the aged adult mouse mammary gland and their relationship to tumorigenesis. J. Cell Physiol. 170, 47-56.
22. Hisaka, T., Yano, H., Haramaki, M., Utsunomiya, I., and Kojiro, M. (1999). Expressions of epidermal growth factor family and its receptor in hepatocellular carcinoma cell lines: relationship to cell proliferation. Int. J. Oncol. 14, 453-460.
23. Horvitz, H. R., and Sternberg, P. W. (1991). Multiple intercellular signaling systems control the development of the Caenorhabditis elegans vulva. Nature 351, 535-541.
24. Iwamoto, R., and Makeda, E. (2000). Heparin-binding EGF-like growth factor: a juxtacrine growth factor. Cyt. Growth Factor Rev. 11, 335-344.
25. Jessell, T. M., and Melton, D. A. (1992). Diffusible factors in vertebrate embryonic induction. Cell 68, 257-270.
26. Jin, M.-H., Sawamoto, K., Ito, M., and Okano, H. (2000). The interaction between the Drosophila secreted protein Argos and the EGF receptor inhibits dimerization of the receptor and binding of secreted Spitz to the receptor. Mol. Cell. Biol. 20, 2098-2107.
27. Kim, H. G., Kassis, J., Souto, J. C., Turner, T., and Wells, A. (1999). EGF receptor signaling in prostate morphogenesis and tumorigenesis. Histol. Histopathol. 14, 1175-1182.
28. Klambt, C. (2002). EGF receptor signaling: Roles of Star and Rhomboid revealed. Curr. Biol. 12, R21-R23.
29. Kornfeld, K. (1997). Vulval development in Caenorhabditis elegans. Trends Genet. 13, 55-61.
30. Lander, A. D., Nie, Q., and Wan, F. Y. M. (2002). Do morphogen gradients arise by diffusion? Dev. Cell 2, 785-796.
31. Lauffenburger, D. A., and Linderman, J. J. (1993). "Receptors: Models for Binding, Trafficking, and Signaling". Oxford University Press.
32. Lauffenburger, D. A., Oehrtman, G. T., Walker, L., and Wiley, H. S. (1998). Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized. Proc. Natl. Acad. Sci. USA 95, 15368-15373.
33. Li, S. W., Plowman, G. D., Buckley, S. D., and Shipley, G. D. (1992). Heparin inhibition of autonomous growth implicates amphiregulin as an autocrine growth factor for normal human mammary epithelial cells. J. Cell Physiol. 153, 103-111.
34. Luettke, N. C., Qiu, T. H., Fenton, S. E., Troyer, K. L., Riedel, R. F., Chang, A., and Lee, D. C. (1999). Targeted inactivation of the EGR and AR genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development 126, 2739-2750.
35. Matsunami, R. K., Yette, M. L., Stevens, A., and Niyogi, S. K. (1991). Mutational analysis of leucine-47 in human EGF. J. Cell Biochem. 46, 242-249.
36. Miettinen, P. J., Chin, J. R., Shum, L., Slavkin, H. C., Shuler, C. F., Derynck, R., and Werb, Z. (1999). EGF receptor function is necessary for normal craniofacial development and palate closure. Nat. Genet. 22, 69-73.
37. Moghal, N., and Sternberg, P. W. (1999). Multiple positive and negative regulators of signaling by the EGF receptor. Curr. Opin. Cell Biol. 11, 190-196.
38. Newman, A. P., and Sternberg, P. W. (1996). Coordinated morphogenesis of epithelia during development of the Caenorhabditis elegans uterine-vulval connection. Proc. Natl. Acad. Sci. USA 93, 9329-9333.
39. Oehrtman, G. T., Wiley, H. S., and Lauffenburger, D. A. (1998). Escape of autocrine ligands into extracellular medium: Experimental test of theoretical model predictions. Biotechnol. Bioeng. 57, 571-582.
40. Panico, L., Dantonio, A., Salvatore, G., Mezza, E., Tortora, G., DeLaurentiis, M., DePlacido, S., Giordano, T., Merino, M., Salomon, D. S., Mullick, W. J., Pettinato, G., Schnitt, S. J., Bianco, A. R., and Ciardiello, F. (1996). Differential immunohistochemical detection of TGFα, amphiregulin and CRIPTO in human normal and malignant breast tissues. Int. J. Cancer 65, 51-56.
41. Piepkorn, M., Pittelkow, M. R., and Cook, P. W. (1998). Autocrine regulation of keratinocytes: The emerging role of heparin-binding, epidermal growth factor-related growth factors. J. Invest. Dermatol. 111, 715-721.
42. Russell, W. E., Dempsey, P. J., Sitaric, S., Peck, A. J., and Coffey, R. J. (1993). Transforming growth factor-alpha concentrations increase in regenerating rat liver: evidence for a delayed accumulation of mature TGFα. Endocrinology 133, 1731-1738.
43. Schroeder, J. A., and Lee, D. C. (1998). Dynamic expression and activation of ErbB receptors in the developing mouse mammary gland. Cell Growth Differ. 9, 451-464.
44. Schweitzer, R., Howes, R., Smith, R., Shilo, B. Z., and Freeman, M. (1995). Inhbition of Drosophila EGF receptor activation by secreted protein Argos. Nature 376, 699-702.
45. Schweitzer, R., and Shilo, B. Z. (1997). A thousand and one roles for the Drosophila EGF receptor. Trends Genet. 13, 191-196.
46. Shoyab, M., Plowman, G. D., McDonald, V. L., Bradley, J. G., and Todaro, G. J. (1989). Structure and function of human amphiregulin: A member of the EGF family. Science 243, 1074-1076.
47. Shvartsman, S. Y., Wiley, H. S., Deen, W. M., and Lauffenburger, D. A. (2001). Spatial range of autocrine signaling: Modeling and computational analysis. Biophys. J. 81, 1854-1867.
48. Shvartsman, S. Y., Muratov, C. B., and Lauffenburger, D. A. (2002). Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis. Development 129, 2577-2589.
49. Snedeker, S. M., Brown, C. F., and DiAugustine, R. P. (1991). Expression and funcational properties of TGFα and EGF during mouse mammary gland ductal morphogenesis. Proc. Natl. Acad. Sci. USA 88, 276-280.
50. Stemerdink, C., and Jacobs, J. R. (1997). Argos and Spitz group genes function to regulate midline glial cell number in Drosophila embryos. Development 124, 3787-3796.
51. Strigini, M., and Cohen, S. M. (1999). Formation of morphogen gradients in the Drosophila wing. Semin. Cell Dev. Biol. 10, 335-344.
52. Teleman, A. A., Strigini, M., and Cohen, S. M. (2001). Shaping morphogen gradients. Cell 105, 559-562.
53. Van Buskirk, C., and Schupbach, T. (1999). Versatility in signalling: Multiple responses to EGF receptor activation during Drosophila oogenesis. Trends Cell Biol. 9, 1-4.
54. van de Poll, M. L., van Vugt, M. J., Lenferink, A. E., and van Zoelen, E. J. (1997). Insertion of Argos sequences into the B-loop of EGF results in a low-affinity ligand with strong agonistic activity. Biochemistry 36, 7425-7431.
55. Vincent, J.-P., and Briscoe, J. (2001). Morphogens. Curr. Biol. 11, R851-R854.
56. Wasserman, J. D., and Freeman, M. (1997). Control of EGF receptor activation in Drosophila. Trends Cell Biol. 7, 431-436.
57. Wasserman, J. D., and Freeman, M. (1998). An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95, 355-364.
58. Wiesen, J. F., Young, P., Werb, Z., and Cunha, G. R. (1999). Signaling through the stromal EGF receptor is necessary for mammary ductal development. Development 126, 335-344.
59. Wiley, H. S., Woolf, M. F., Opresko, L. K., Burke, P. M., Will, B., Morgan, J. R., and Lauffenburger, D. A. (1998). Removal of the membrane-anchoring domain of EGF leads to intracrine signaling and disruption of mammary epithelial cell organization. J. Cell Biol. 143, 1317-1328.
60. Will, B., Lauffenburger, D. A., and Wiley, H. S. (1995). Studies on engineering autocrine systems: Requirements for ligand release from cells producing an artifical growth factor. Tissue Eng. 1, 81-94.
61. Yarden, Y. (2001). The EGF receptor family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities. Eur. J. Cancer 37, S3-S8.