Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer

Oncology Reports

Volumn 15, Issue 1, 2006, Pages 221-225

  Li, Shao Ying ^a   Rong, Minna ^a   Iacopetta, Barry ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Breast cancer; DNA methylation; Methyl group metabolism; Polymorphism

Indexed keywords

5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; DNA; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3B; ESTROGEN RECEPTOR; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); PROGESTERONE RECEPTOR; THYMIDYLATE SYNTHASE;

ARTICLE; BREAST TUMOR; CPG ISLAND; DNA METHYLATION; ENZYMOLOGY; FEMALE; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; HUMAN; METABOLISM; MUTATION;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; BREAST NEOPLASMS; CPG ISLANDS; CYSTATHIONINE BETA-SYNTHASE; DNA; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, GENETIC; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; THYMIDYLATE SYNTHASE;

EID: 33644875687     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.15.1.221     Document Type: Article

References (22)

1. Yang X, Yan L and Davidson NE: DNA methylation in breast cancer. Endocr Relat Cancer 8: 115-127, 2001. (Pubitemid 32641353)
2. Szyf M, Pakneshan P and Rabbani SA: DNA methylation and breast cancer. Biochem Pharmacol 68: 1187-1197, 2004. (Pubitemid 39094284)
3. Paz MF, Avila S, Fraga MF, et al: Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res 62: 4519-4524, 2002. (Pubitemid 34827317)
4. Shen H, Wang L, Spitz MR, et al: A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer. Cancer Res 62: 4992-4995, 2002. (Pubitemid 34984424)
5. Chen J, Kyte C, Valcin M, et al: Polymorphisms in the one-carbon metabolic pathway, plasma folate levels and colorectal cancer in a prospective study. Int J Cancer 110: 617-620, 2004. (Pubitemid 38658029)
6. Sharp L and Little J: Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review. Am J Epidemiol 159: 423-443, 2004. (Pubitemid 38280289)
7. Shannon B, Gnanasampanthan S, Beilby J and Iacopetta B: A polymorphism in the methylenetetrahydrofolate reductase gene predisposes to colorectal cancers with microsatellite instability. Gut 50: 520-524, 2002. (Pubitemid 34638872)
8. Li SY, Rong M and Iacopetta B: DNA hypermethylation in breast cancer and its association with clinicopathological features. Cancer Lett (In press).
9. Soong R, Iacopetta BJ, Harvey JM, et al: Detection of p53 gene mutation by rapid PCR-SSCP and its association with poor survival in breast cancer. Int J Cancer 74: 642-647, 1997. (Pubitemid 28037509)
10. Grieu F, Powell B, Beilby J and Iacopetta B: Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype. Anticancer Res 24: 3215-3219, 2004. (Pubitemid 39390975)
11. Grieu F, Joseph D, Norman P and Iacopetta B: Development of a rapid genotyping method for single nucleotide polymorphisms and its application in cancer studies. Oncol Rep 11: 501-504, 2004.
12. Le Marchand L, Haiman CA, Wilkens LR, Kolonel LN and Henderson BE: MTHFR polymorphisms, diet, HRT, and breast cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev 13: 2071-2077, 2004. (Pubitemid 40054300)
13. Langsenlehner U, Krippl P, Renner W, et al : The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk. Breast Cancer Res Treat 81: 169-172, 2003. (Pubitemid 37211134)
14. Shrubsole MJ, Gao YT, Cai Q, et al: MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Epidemiol Biomarkers Prev 13: 190-196, 2004. (Pubitemid 38222548)
15. Campbell IG, Baxter SW, Eccles DM and Choong DY: Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer. Breast Cancer Res 4: R14, 2002.
16. Etienne MC, Ilc K, Formento JL, et al: Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms: relationships with 5-fluorouracil sensitivity. Br J Cancer 90: 526-534, 2004. (Pubitemid 38250655)
17. Sohn KJ, Croxford R, Yates Z, Lucock M and Kim YI: Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate. J Natl Cancer Inst 96: 134-144, 2004. (Pubitemid 38195904)
18. Kang S, Kim JW, Kang GH, et al: Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer. Gynecol Oncol 96: 173-180, 2005. (Pubitemid 39612433)
19. Mariadason JM, Arango D, Shi Q, et al : Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. Cancer Res 63: 8791-8812, 2003. (Pubitemid 38064059)
20. Takechi T, Koizumi K, Tsujimoto H and Fukushima M: Screening of differentially expressed genes in 5-fluorouracil-resistant human gastrointestinal tumor cells. Jpn J Cancer Res 92: 696-703, 2001. (Pubitemid 32633474)
21. Montgomery KG, Liu MC, Eccles DM and Campbell IG: The DNMT3B C->T promoter polymorphism and risk of breast cancer in a British population: a case-control study. Breast Cancer Res 6: R390-394, 2004.
22. Bieche I, Tozlu S, Girault I and Lidereau R: Identification of a three-gene expression signature of poor-prognosis breast carcinoma. Mol Cancer 3: 37, 2004.