Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV

Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2002, Pages 888-893

  Kim, Chu Young ^a   Whittington, Douglas A ^a   Chang, Jeanne S ^a   Liao, John ^b   May, Jesse A ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AL 6619; AL 6629; AL 8520; BRINZOLAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE II INHIBITOR; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV; CARBONATE DEHYDRATASE IV INHIBITOR; SULFONAMIDE; THIENO[3,2 E] 1,2 THIAZINE 6 SULFONAMIDE 2 (3 HYDROXYPHENYL) 3 (4 MORPHOLINYLMETHYL) 1,1 DIOXIDE; THIENO[3,2 E] 1,2 THIAZINE 6 SULFONAMIDE 2 (3 METHOXYPHENYL) 3 (4 MORPHOLINYLMETHYL) 1,1 DIOXIDE; THIENO[3,2 E] 1,2 THIAZINE 6 SULFONAMIDE 4 AMINO 3,4 DIHYDRO 2 (3 METHOXYPROPYL) 1,1 DIOXIDE; THIENO[3,2 E] 1,2 THIAZINE 6 SULFONAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

AQUEOUS HUMOR FLOW; ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; COMPUTER PREDICTION; CRYSTAL STRUCTURE; DRUG BINDING; DRUG FORMULATION; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; ENZYME STRUCTURE; GLAUCOMA; HUMAN; INTRAOCULAR PRESSURE; MATHEMATICAL COMPUTING; MOLECULAR DYNAMICS; NONHUMAN; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

CARBONIC ANHYDRASE II; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASE IV; CRYSTALLOGRAPHY, X-RAY; CYCLIC S-OXIDES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; SUBSTRATE SPECIFICITY; SULFONAMIDES; THIAZINES;

EID: 0037075147     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010163d     Document Type: Article

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