Simultaneous blockade of 5-HT1A/B receptors and 5-HT transporters results in acute increases in extracellular 5-HT in both rats and guinea pigs: In vivo characterization of the novel 5-HT1A/B receptor antagonist/5-HT transport inhibitor SB-649915-B

Psychopharmacology

Volumn 192, Issue 1, 2007, Pages 121-133

  Hughes, Zoë A ^a   Starr, Kathryn R ^a   Scott, Claire M ^a   Newson, Michael J ^b   Sharp, Trevor ^b   Watson, Jeannette M ^a   Hagan, Jim J ^a   Dawson, Lee A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

5 HT (serotonin); 5 HT autoreceptor; Depression; Ex vivo binding; Guinea pig; Microdialysis; Paroxetine; Rat

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 (2 DIMETHYLAMINOETHYL) 4 CHLORO 5 PROPOXYINDOLE; 6 [[1 [2 [(2 METHYL 5 QUINOLINYL)OXY]ETHYL] 4 PIPERIDINYL]METHYL] 2H 1,4 BENZOXAZIN 3(4H) ONE; AUTORECEPTOR; PAROXETINE; RADIOLIGAND; SB 649915B; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN AGONIST; SEROTONIN TRANSPORTER; TRITIUM; UNCLASSIFIED DRUG;

ACUTE DRUG ADMINISTRATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DENTATE GYRUS; DORSAL RAPHE NUCLEUS; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; EX VIVO STUDY; GUINEA PIG; IN VIVO STUDY; LIGAND BINDING; LOCOMOTION; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; RECEPTOR OCCUPANCY; SEIZURE THRESHOLD; SEROTONIN UPTAKE;

ANIMALS; BENZOXAZINES; DENTATE GYRUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ELECTROSHOCK; GUINEA PIGS; LOCOMOTION; MALE; MICRODIALYSIS; MOOD DISORDERS; NEURONS; PIPERIDINES; PREFRONTAL CORTEX; QUINOLINES; RADIOLIGAND ASSAY; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; SEIZURES; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; SPECIES SPECIFICITY;

EID: 34247588125     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0691-x     Document Type: Article

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