Selective vulnerability to ischemia in the rat spinal cord: A comparison between ventral and dorsal horn neurons

Spine

Volumn 32, Issue 10, 2007, Pages 1060-1066

  Nohda, Kazuhiro ^a   Nakatsuka, Terumasa ^b   Takeda, Daisuke ^a   Miyazaki, Nobuyuki ^a   Nishi, Hideto ^a   Sonobe, Hideki ^a   Yoshida, Munehito ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

Author keywords

Cell death; Electrophysiology; Ischemia; Patch clamp; Spinal neurons

Indexed keywords

GLUCOSE; OXYGEN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE PREDISPOSITION; ELECTRIC CURRENT; NERVE CELL MEMBRANE POTENTIAL; NERVE CELL MEMBRANE STEADY POTENTIAL; NONHUMAN; NUTRIENT LIMITATION; OXYGEN CONSUMPTION; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECORDING; SPINAL CORD DORSAL HORN; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; SPINAL CORD NERVE CELL; SPINAL CORD VENTRAL HORN; SPRAGUE DAWLEY RAT; TISSUE CULTURE;

ANIMALS; ANTERIOR HORN CELLS; CULTURE MEDIA; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUCOSE; ISCHEMIA; ORGAN CULTURE TECHNIQUES; OXYGEN; PATCH-CLAMP TECHNIQUES; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34247585648     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000261560.53428.90     Document Type: Article

References (26)

1. Cervos-Navarro J, Diemer NH. Selective vulnerability in brain hypoxia. Crit Rev Neurobiol 1991;6:149-82.
2. Schmidt-Kastner R, Freund TF. Selective vulnerability of the hippocampus in brain ischemia. Neuroscience 1991;40:599-636.
3. Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Science 1993;262:689-95.
4. Brierley JB, Graham DI, Adams JH, et al. Neocortical death after cardiac arrest: a clinical, neurophysiological, and neuropathological report of two cases. Lancet 1971;2:560-5.
5. Garland H, Greenberg J, Harriman DG. Infarction of the spinal cord. Brain 1966;89:645-62.
6. Marcus ML, Heistad DD, Ehrhardt JC, et al. Regulation of total and regional spinal cord blood flow. Circ Res 1977;41:128-34.
7. Duggal N, Lach B. Selective vulnerability of the lumbosacral spinal cord after cardiac arrest and hypotension. Stroke 2002;33:116-21.
8. Anderson DK, Demediuk P, Saunders RD, et al. Spinal cord injury and protection. Ann Emerg Med 1985;14:816-21.
9. Frankel HL, Hancock DO, Hyslop G, et al. The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia. I. Paraplegia 1969;7:179-92.
10. Laschinger JC, Izumoto H, Kouchoukos NT. Evolving concepts in prevention of spinal cord injury during operations on the descending thoracic and thoracoabdominal aorta. Ann Thorac Surg 1987;44:667-74.
11. Sakurai M, Aoki M, Abe K, et al. Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 1997;113:159-64.
12. Tanaka E, Yamamoto S, Kudo Y, et al. Mechanisms underlying the rapid depolarization produced by deprivation of oxygen and glucose in rat hippocampal CA1 neurons in vitro. J Neurophysiol 1997;78:891-902.
13. Thompson RJ, Zhou N, MacVicar BA. Ischemia opens neuronal gap junction hemichannels. Science 2006;312:924-7.
14. Nakatsuka T, Ataka T, Kumamoto E, et al. Alteration in synaptic inputs through C-afferent fibers to substantia gelatinosa neurons of the rat spinal dorsal horn during postnatal development. Neuroscience 2000;99:549-56.
15. Nakatsuka T, Gu JG. ATP P2X receptor-mediated enhancement of glutamate release and evoked EPSCs in dorsal horn neurons of the rat spinal cord. J Neurosci 2001;21:6522-31.
16. Machida M, Weinstein SL, Yamada T, et al. Dissociation of muscle action potentials and spinal somatosensory evoked potentials after ischemic damage of spinal cord. Spine 1988;13:1119-24.
17. Iseli E, Cavigelli A, Dietz V, et al. Prognosis and recovery in ischaemic and traumatic spinal cord injury: clinical and electrophysiological evaluation. J Neurol Neurosurg Psychiatry 1999;67:567-71.
18. Penny JE, Kukums JR, Tyrer JH, et al. Quantitative oxidative enzyme histochemistry of the spinal cord: 2. Relation of cell size and enzyme activity to vulnerability to ischaemia. J Neurol Sci 1975;26:187-92.
19. Leifer D, Kowall NW. Immunohistochemical patterns of selective cellular vulnerability in human cerebral ischemia. J Neurol Sci 1993;119:217-28.
20. Fischer CP, Jorgen G, Gundersen H, et al. Preferential loss of large neocortical neurons during HIV infection: a study of the size distribution of neocortical neurons in the human brain. Brain Res 1999;828:119-26.
21. Hsu M, Buzsaki G. Vulnerability of mossy fiber targets in the rat hippocampus to forebrain ischemia. J Neurosci 1993;13:3964-79.
22. Liu D, Smith CL, Barone FC, et al. Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain. Brain Res Mol Brain Res 1999;68:29-41.
23. Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 2004;21:754-74.
24. Hugon J, Vallat JM, Spencer PS, et al. Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord. Neurosci Lett 1989;104:258-62.
25. Ikonomidou C, Qin Y, Labruyere J, et al. Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 1996;55:211-24.
26. Vandenberghe W, Robberecht W, Brorson JR. AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability. J Neurosci 2000;20:123-32.