Preferential loss of large neocortical neurons during HIV infection: A study of the size distribution of neocortical neurons in the human brain

Brain Research

Volumn 828, Issue 1-2, 1999, Pages 119-126

  Fischer, Christian P ^a   Jørgen G Gundersen, Hans ^b   Pakkenberg, Bente ^a  

^a Illinois   (Denmark)

^b NONE

Author keywords

Acquired immunodeficiency syndrome; Human immunodeficiency virus; Neocortex; Neuronal loss; Neuronal size distribution; Optical dissector; Rotator; Stereology

Indexed keywords

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CELL COUNT; CELL LOSS; CELL SIZE; CELL VOLUME; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; INTERNEURON; MALE; MOTONEURON; NEOCORTEX; PERIKARYON; PRIORITY JOURNAL; STEREOLOGY; TISSUE DISTRIBUTION;

EID: 0345517094     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01344-X     Document Type: Article

References (45)

1. Abe H., Mehraein P., Weis S. Degeneration of the cerebellar dentate nucleus and the inferior olivary nuclei in HIV-1-infected brains: a morphometric analysis. Acta Neuropathol. 92:1996;150-155.
2. Aggoun-Zouaoui D., Charriaut-Marangue C., Rivera S., Jorquera I., Ben-Ari Y., Represa A. The HIV-1 envelope protein gp120 induces neuronal apoptosis in hippocampal slices. NeuroReport. 7:1996;433-436.
3. Asare E., Dunn G., Glass J., McArthur J., Luthert P., Lantos P., Everall I. Neuronal pattern correlates with the severity of human immunodeficiency virus-associated dementia complex. Usefulness of spatial pattern analysis in clinicopathological studies. Am. J. Pathol. 148:1996;31-38.
4. Aylward E.H., Brettschneider P.D., McArthur J.C., Harris G.J., Schlaepfer T.E., Henderer J.D., Barta P.E., Tien Magnetic resonance imaging measurement of gray matter volume reductions in HIV dementia. Am. J. Psychiatry. 152:1995;987-994.
5. Aylward E.H., Henderer J.D., McArthur J.C., Brettschneider P.D., Harris G.J., Barta P.E., Pearlson G.D. Reduced basal ganglia volume in HIV-1-associated dementia: results from quantitative neuroimaging. Neurology. 43:1993;2099-2104.
6. Braengaard H., Evans S.M., Howard C.V., Gundersen H.J.G. The total number of neurons in the human neocortex unbiasedly estimated using optical dissectors. J. Microsc. 157:1990;285-304.
7. Budka H. Neuropathology of human immunodeficiency virus infection. Brain Pathol. 1:1991;163-175.
8. Budka H., Wiley C.A., Kleihues P., Artigas J., Asbury A.K., Cho E.-S., Cornblath D.R., Canto M.C.D., DeGirolami U., Dickson D., Epstein L.G., Esiri M.M., Giangaspero F., Gosztonyi G., Gray F., Griffin J.W., Hénin D., Iwasaki Y., Janssen R.S., Johnson R.T., Lantos P.L., Lyman W.D., McArthur J.C., Nagashima K., Peress N., Petito C.K., Price R.W., Rhodes R.H., Rosenblum M., Said G., Scaravilli F., Sharer L.R., Vinters H.V. HIV-associated disease of the nervous system: review of nomenclature and proposal for neurpathology-based terminology. Brain Pathol. 1:1991;143-152.
9. Diop A.G., Lesort M., Esclaire F., Dumas M., Hugon J. Calbindin D28K-containing neurons, and not HSP70-expressing neurons, are more resistant to HIV-1 envelope (gp120) toxicity in cortical cell cultures. J. Neurosci. Res. 42:1995;252-258.
10. Everall I.P., Barnes H., Spargo E., Lantos P.L. Assessment of neuronal density in the putamen in the human immunodeficiency virus (HIV) infection. Application of stereology and spatial analysis of quadrats. J. Neurovirol. 1:1995;126-129.
11. Everall I.P., Glass J.D., McArthur J.C., Spargo E., Lantos P.L. Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia. Acta Neuropathol. 88:1994;538-544.
12. Everall I.P., Luthert P.J., Lantos P.L. Neuronal loss in the frontal cortex in HIV infection. Lancet. 337:1991;1119-1121.
13. Everall I.P., Luthert P.J., Lantos P.L. Neuronal number and volume alterations in the neocortex of HIV infected individuals. J. Neurol., Neurosurg. Psychiatry. 56:1993;481-486.
14. Gelbard H.A., Nottet H.S., Swindells S., Jett M., Dzenko K.A., Genis P., White R., Wang L., Choi Y.B., Zhang D., Lipton S.A., Tourtellotte W.W., Epstein L.G., Gendelman H.E. Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. J. Virol. 68:1994;4628-4635.
15. Glass J.D., Wesselingh S.L., Selnes O.A., McArthur J.C. Clinical-neuropathologic correlation in HIV-associated dementia. Neurology. 43:1993;2230-2237.
16. Gray F., Gherardi R., Keohane C., Favolini M., Sobel A., Poirier J. Pathology of the central nervous system in 40 cases of acquired immunodeficiency syndrome (AIDS). Neuropathol. Appl. Neurobiol. 14:1988;365-380.
17. Gray F., Haug H., Chimelli L., Geny C., Gaston A., Scaravilli F., Budka H. Prominent cortical atrophy with neuronal loss as correlate of human immunodeficiency virus encephalopathy. Acta Neuropathol. 82:1991;229-233.
18. Gundersen H.J.G., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J. Microsc. 147:1987;229-263.
19. Harris G.J., Pearlson G.D., McArthur J.C., Zeger S., LaFrance N.D. Altered cortical blood flow in HIV-seropositive individuals with and without dementia: a single photon emission computed tomography study. AIDS. 8:1994;495-499.
20. Hirsch E.C. Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease? Ann. Neurol. 32:1992;88-93.
21. Jensen E.B.V., Gundersen H.J.G. The rotator. J. Microsc. 170:1993;35-44.
22. Ketzler S., Weis S., Haug H., Budka H. Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol. 80:1990;92-94.
23. Leifer D., Kowall N.W. Immunohistochemical patterns of selective cellular vulnerability in human cerebral ischemia. J. Neurol. Sci. 119:1993;217-228.
24. Masliah E., Ge N., Achim C.L., Wiley C.A. Selective neuronal vulnerability in HIV encephalitis. J. Neuropathol. Exp. Neurol. 51:1992;585-593.
25. Masliah E., Ge N., Achim C.L., Wiley C.A. Cytokine receptor alterations during HIV infection in the human central nervous system. Brain Res. 663:1994;1-6.
26. McArthur J.C., Hoover D.R., Bacellar H., Miller E.N., Cohen B.A., Becker J.T., Graham N.M.H., McArthur J.H., Selnes O.A., Jacobsen L.P., Visscher B.R., Concha M., Saar A. Dementia in AIDS patients. Neurology. 43:1993;2245-2252.
27. Migheli A., Piva R., Atzori C., Troost D., Schiffer D. c-Jun, JNK/SAPK kinases and transcription factor NF-kappa B are selectively activated in astrocytes, but not in motor neurons, in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 56:1997;1314-1322.
28. Oster S., Christoffersen P., Gundersen H.J.G., Nielsen J.O., Pakkenberg B., Pedersen C. Cerebral atrophy in AIDS: a stereological study. Acta Neuropathol. 85:1993;617-622.
29. Oster S., Christoffersen P., Gundersen H.J.G., Nielsen J.O., Pedersen C., Pakkenberg B. Six billion neurons lost in AIDS. A stereological study of the neocortex. APMIS. 103:1995;525-529.
30. Power C., Kong P.A., Crawford T.O., Wesselingh S.L., Glass J.D., McArthur J.C., Trapp B.D. Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations of the blood-brain barrier. Ann. Neurol. 34:1993;339-350.
31. Raininko R., Elovaara I., Poutianen E., Virta A., Valanne L., Haltia M., Lahdevirta J. A prospective radiologic and neurologic follow-up study of 61 HIV-infected subjects: early beginning and slow progression of brain atrophy. Eur. J. Neurol. 4:1997;143-151.
32. Regeur L., Jensen G.B., Pakkenberg H., Evans S.M., Pakkenberg B. No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type. Neurobiol. Aging. 15:1994;347-352.
33. Rhodes R.H. Histopathologic features in the central nervous system of 400 acquired immunodefiency syndrome cases: implications of rates of occurrence. Hum. Pathol. 24:1993;1189-1198.
34. Sadar A.M., Reynolds G.P. Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia. Neurosci. Lett. 187:1995;9-12.
35. Sakurai M., Aoki M., Abe K., Sadahiro M., Tabayashi K. Selective motor neuron death and heat shock protein induction after spinal cord ischemia in rabbits. J. Thorac. Cardiovasc. Surg. 113:1997;159-164.
36. Selnes O.A., Galai N., Bacellar H., Miller E.N., Becker J.T., Wesch J., Van Gorp W., McArthur J.C. Cognitive performance after progression to AIDS: a longitudinal study from the Multicenter AIDS Cohort Study. Neurology. 45:1995;267-275.
37. Sharer L.R. Pathology of HIV-1 infection of the central nervous system. A review. J. Neuropathol. Exp. Neurol. 51:1992;3-11.
38. Subbiah P., Mouton P., Fedor H., McArthur J.C., Glass J.D. Stereological analysis of cerebral atrophy in human immunodeficiency virus-associated dementia. J. Neuropathol. Exp. Neurol. 55:1996;1032-1037.
39. Takahashi K., Wesselingh S.L., Griffin D.E., McArthur J.C., Johnson, Glass J.D. Localization of HIV-1 in human brain using polymerase chain reaction/in situ hybridization and immunochemistry. Ann. Neurol. 39:1996;705-711.
40. Tracey I., Carr C.A., Guimaraes A.R., Worth J.L., Navia B.A., Gonzalez R.G. Brain choline-containing compounds are elevated in HIV-positive patients before the onset of AIDS dementia complex: a proton magnetic resonance spectroscopic study. Neurology. 46:1996;783-788.
41. Tyor W.R., Glass J.D., Griffin J.W., Becker P.S., McArthur J.C., Bezman L., Griffin D.E. Cytokine expression in brain during the acquired immunodeficiency syndrome. Ann. Neurol. 31:1992;349-360.
42. Weis S., Haug H., Budka H. Neuronal damage in the cerebral cortex of AIDS brains: a morphometric study. Acta Neuropathol. 85:1993;185-189.
43. Wesselingh S.L., Power C., Glass J.D., Tyor W.R., McArthur J.C., Farber J.M., Griffin J.W., Griffin D.E. Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia. Ann. Neurol. 33:1993;576-582.
44. Wiley C.A., Masliah E., Morey M., Lemere C., DeTeresa R., Grafe M., Hansen L., Terry R. Neocortical damage during HIV infection. Ann. Neurol. 29:1991;651-657.
45. Wu P., Price P., Du B., Hatch W.C., Terwilliger E.F. Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons. NeuroReport. 7:1996;1045-1049.