Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 12, 2007, Pages 4057-4068

  Rönn, Robert ^a   Gossas, Thomas ^b   Sabnis, Yogesh A ^a   Daoud, Hanna ^a   Åkerblom, Eva ^a   Danielson, U Helena ^b   Sandström, Anja ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Bioisostere; HCV; Hepatitis C; NS3; Protease inhibitor

Indexed keywords

AMIDE; CARBOXYLIC ACID DERIVATIVE; CYANAMIDE; FUNCTIONAL GROUP; HYDRAZIDE DERIVATIVE; HYDROXAMIC ACID; NONSTRUCTURAL PROTEIN 3; PROTEINASE INHIBITOR; SULFINAMIDE; TETRAZOLE DERIVATIVE;

ACIDITY; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL ASSAY; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; HEPATITIS C VIRUS; HYDROGEN BOND; PH;

CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PROTEASE INHIBITORS; SERINE ENDOPEPTIDASES;

HEPATITIS C VIRUS;

EID: 34247585525     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.089     Document Type: Article

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