G-protein β3 subunit gene (GNB3) variant in causation of essential hypertension

Hypertension

Volumn 32, Issue 6, 1998, Pages 1094-1097

  Benjafield, Adam V ^a   Jeyasingam, Cheryl L ^a   Nyholt, Dale R ^b   Griffiths, Lyn R ^b   Morris, Brian J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

Blood pressure; G protein; Genetics; Hypertension, essential; Race

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN SUBUNIT;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RACE; AUSTRALIA; CHEMISTRY; COMPARATIVE STUDY; GENETICS; HYPERTENSION; MIDDLE AGED; ONSET AGE;

AGE OF ONSET; AUSTRALIA; FEMALE; GENOTYPE; GTP-BINDING PROTEINS; HUMANS; HYPERTENSION; MALE; MIDDLE AGED;

EID: 0032217177     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.32.6.1094     Document Type: Article

References (24)

1. Rosskopf D, Düsing R, Siffert W. Membrane sodium-proton exchange and primary hypertension. Hypertension. 1993;21:607-617.
2. Siffert W, Düsing R. Sodium-proton exchange and primary hypertension: an update. Hypertension. 1995;26:649-655.
3. Siffert W, Rosskopf D, Morit± A, Wieland T, Kaldenberg-Stasch S, Kettler N, Hartung K, Beckmann S, Jakobs KH. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension. J Clin Invest. 1995;96:759-966.
4. i3, Gβ1, and Gβ2 are not mutated. Circ Res. 1996;79:974-983.
5. Ansaru-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Gen Res. 1996;6: 314-326.
6. Siffert W, Rosskopf D, Siffert G, Busch S, Moritz A, Erbel R, Sharma AM, Ritz E, Wichmann H-E, Jakobs KH, Horsthemke B. Association of a human G-protein β3 subunit variant with hypertension. Nat Genet 1998;18:45-48.
7. Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 Å crystal structure of a heterotrimeric G protein. Nature. 1996;379: 311-319.
8. A protein bg dimer at 2.1 Å resolution. Nature. 1996;379: 369-374.
9. Iiri T, Farfel Z, Bourne HR. G-protein diseases furnish a model for the turn-on switch. Nature. 1998;394:35-38.
10. Morris BJ, Zee RYL, Schrader AP. Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals. J Clin Invest. 1994;94:1085-1089.
11. Morris BJ, Jeyasingam CL, Zhang W, Curtain RP, Griffiths LR. Influence of family history on frequency of glucagon receptor Gly40Ser mutation in hypertensive subjects. Hypertension. 1997;30:1640-1641.
12. Zee RYL, Ying L-H, Griffiths LR, Morris BJ. Association and linkage analyses of restriction fragment length polymorphisms for the human renin and antithrombin III genes in essential hypertension. J Hypertens. 1991;9:825-830.
13. Morris BJ, Zee RYL, Ying L-H, Griffiths LR. Independent, marked associations of alleles of the insulin receptor and dipeptidyl carboxypeptidase-1 genes with essential hypertension. Clin Sci. 1993;85: 189-195.
14. Chambers SM, Morris BJ. Glucagon receptor gene mutation in essential hypertension. Nat Genet. 1996;12:122. Letter.
15. Miller SA, Dykes KK, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988; 16:1215.
16. Morris BJ, Robinson BG, Zee RYL. Significant relationships of plasma lipids and body mass index with polymorphisms at the linked LDL receptor gene and insulin receptor gene loci (19p13.2) in essential hypertensives. Clin Sci. 1994;86:583-592.
17. Skinner SL. Improved assay methods for renin "concentration" and "activity" in human plasma. Circ Res. 1967;20:391-402.
18. Lumbers ER, Reid GC. Effects of vaginal delivery and caesarian section on plasma renin activity and angiotensin II levels in human umbilical cord blood. Biol Neonate. 1977;31:127-134.
19. Morris BJ, de Zwart RT, Young JA. Renin in mouse but not in rat submandibular glands. Experientia. 1980;36:1333-1334.
20. 235→Thr variant of angiotensinogen gene in severe, familial hypertension. Biochem Biophys Res Commun. 1993;197:833-839.
21. Khoury MJ, Beaty TH, Cohen BH. Fundamentals of genetic epidemiology. In: Kelsey JL, Marmot MG, Stolley PD, Vessey MP, eds. Monographs in Epidemiology and Biostatistics. Vol 19. New York, NY: Oxford University Press; 1993.
22. Hodge SE. What association analysis can and cannot tell us about the genetics of complex disease. Am J Med Genet. 1994;54:318-323.
23. Lander ES, Schork NJ. Genetic dissection of complex traits. Science. 1994;265:2037-2048.
24. Kruglyak L, Lander ES. High-resolution genetic mapping of complex traits. Am J Hum Genet. 1995;56:1212-1223.