Impaired β-adrenergically mediated lipolysis in skeletal muscle of obese subjects

Diabetologia

Volumn 47, Issue 8, 2004, Pages 1462-1468

  Blaak, E E ^a   Schiffelers, S L ^a   Saris, W H ^a   Mensink, M ^a   Kooi, M E ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

adrenergic stimulation; Intramyocellular lipids; Lipolysis; Obesity; Skeletal muscle

Indexed keywords

ALCOHOL; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BIOLOGICAL MARKER; GLYCEROL; SALBUTAMOL; TRIACYLGLYCEROL;

ADRENERGIC SYSTEM; ADULT; ARTICLE; BIOACCUMULATION; BODY FAT; CELL LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DILUTION; EXTRACELLULAR FLUID; GASTROCNEMIUS MUSCLE; HUMAN; HUMAN EXPERIMENT; INTERSTITIAL FLUID; LIPOLYSIS; MALE; MICRODIALYSIS; MOLECULAR PROBE; MUSCLE BLOOD FLOW; MUSCLE LEVEL; MUSCLE METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PERFUSION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SKELETAL MUSCLE;

ADRENERGIC BETA-AGONISTS; ALBUTEROL; BODY COMPOSITION; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIPOLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICRODIALYSIS; MUSCLE, SKELETAL; OBESITY; REFERENCE VALUES;

EID: 4544324948     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1471-y     Document Type: Article

References (36)

1. Colberg SR, Simoneau JA, Thaete FL, Kelley DE (1995) Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest 95:1846-1853
2. Blaak EE, Van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH (1994) Beta-adrenergic stimulation of energy expenditure and forearm skeletal muscle metabolism in lean and obese men. Am J Physiol 267:E306-E315
3. He J, Watkins S, Kelley DE (2001) Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes 50:817-823
4. Malenfant P, Joanisse DR, Theriault R, Goodpaster BH, Kelley DE Simoneau JA (2001) Fat content in individual muscle fibers of lean and obese subjects. Int J Obes Relat Metab Disord 25:1316-1321
5. Sinha R, Dufour S, Petersen KF et al. (2002) Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51:1022-1027
6. Perseghin G, Scifo P, Danna M et al. (2002) Normal insulin sensitivity and IMCL content in overweight humans are associated with higher fasting lipid oxidation. Am J Physiol Endocrinol Metab 283:E556-E564
7. Krssak M, Falk Petersen K, Dresner A et al. (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113-116
8. Pan DA, Lillioja S, Kriketos AD et al. (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988
9. Perseghin G, Scifo P, De Cobelli F et al. (1999) Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606
10. Jacob S, Machann J, Rett K et al. (1999) Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects. Diabetes 48:1113-1119
11. Schmitz-Peiffer C (2000) Signalling aspects of insulin resistance in skeletal muscle: mechanisms induced by lipid oversupply. Cell Signal 12:583-594
12. Ellis BA, Poynten A, Lowy AJ et al. (2000) Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol Endocrinol Metab 279:E554-E560
13. Langfort J, Ploug T, Ihlemann J et al. (1998) Hormone-sensitive lipase (HSL) expression and regulation in skeletal muscle. Adv Exp Med Biol 441:219-228
14. Langfort J, Ploug T, Ihlemann J, Saldo M, Holm C, Galbo H (1999) Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle. Biochem J 340:459-465
15. Hagstrom-Toft E, Enoksson S, Moberg E, Bolinder J, Arner P (1998) beta-Adrenergic regulation of lipolysis and blood flow in human skeletal muscle in vivo. Am J Physiol 275: E909-E916
16. Stumvoll M, Jacob S, Wahl HG et al. (2000) Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans. J Clin Endocrinol Metab 85:3740-3745
17. Bolinder J, Kerckhoffs DA, Moberg E, Hagstrom-Toft E, Arner P (2000) Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects. Diabetes 49:797-802
18. Siri W (1956) The gross composition of the body. Adv Exp Med Biol 4:239-280
19. Stahle L, Segersvard S, Ungerstedt U (1991) A comparison between three methods for estimation of extracellular concentrations of exogenous and endogenous compounds by microdialysis. J Pharmacol Methods 25:41-52
20. Arner P, Bulow J (1993) Assessment of adipose tissue metabolism in man: comparison of Fick and microdialysis techniques. Clin Sci (Lond) 85:247-256
21. Vanhamme L, Boogaart A van den, Van Huffel S (1997) Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 129:35-43
22. Naressi A, Couturier C, Devos JM et al. (2001) Java-based graphical user interface for the MRUI quantitation package. MAGMA 12:141-152
23. Schrauwen-Hinderling VB, Schrauwen P, Hesselink MK et al. (2003) The increase in intramyocellular lipid content is a very early response to training. J Clin Endocrinol Metab 88:1610-1616
24. Schick F, Eismann B, Jung WI, Bongers H, Bunse M, Lutz O (1993) Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 29:158-167
25. Hagstrom-Toft E, Thorne A, Reynisdottir S et al. (2001) Evidence for a major role of skeletal muscle lipolysis in the regulation of lipid oxidation during caloric restriction in vivo. Diabetes 50:1604-1611
26. Enoksson S, Degerman E, Hagstrom-Toft E, Large V, Arner P (1998) Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man. Diabetologia 41:560-568
27. Schiffelers SL, Akkermans JA, Saris WH, Blaak EE (2003) Lipolytic and nutritive blood flow response to beta-adrenoceptor stimulation in situ in subcutaneous abdominal adipose tissue in obese men. Int J Obes Relat Metab Disord 27:227-231
28. Kelley DE, Mandarino LJ (2000) Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49:677-683
29. Blaak EE, Van Baak MA, Kemerink GJ, Pakbiers MT, Heidendal GA, Saris WH (1994) beta-Adrenergic stimulation of skeletal muscle metabolism in relation to weight reduction in obese men. Am J Physiol 267:E316-E322
30. Hulver MW, Berggren JR, Cortright RN et al. (2003) Skeletal muscle lipid metabolism with obesity. Am J Physiol Endocrinol Metab 284:E741-E747
31. Guo Z, Jensen MD (1999) Blood glycerol is an important precursor for intramuscular triacylglycerol synthesis. J Biol Chem 274:23702-23706
32. Sjostrand M, Gudbjornsdottir S, Holmang A, Strindberg L, Ekberg K, Lonnroth P (2002) Measurements of interstitial muscle glycerol in normal and insulin-resistant subjects. J Clin Endocrinol Metab 87:2206-2211
33. Hagstrom-Toft E, Qvisth V, Nennesmo I et al. (2002) Marked heterogeneity of human skeletal muscle lipolysis at rest. Diabetes 51:3376-3383
34. Rico-Sanz J, Hajnal JV, Thomas EL, Mierisova S, Ala-Korpela M, Bell JD (1998) Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans. J Physiol 510:615-622
35. Hwang JH, Pan JW, Heydari S, Hetherington HP, Stein DT (2001) Regional differences in intramyocellular lipids in humans observed by in vivo 1H-MR spectroscopic imaging. J Appl Physiol 90:1267-1274
36. Laakso M, Edelman SV, Brechtel G, Baron AD (1990) Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance. J Clin Invest 85:1844-1852