Biased tests of association: Comparisons of allele frequencies when departing from Hardy-Weinberg proportions

American Journal of Epidemiology

Volumn 149, Issue 8, 1999, Pages 706-711

  Schaid, Daniel J ^a   Jacobsen, Steven J ^a  

^a MAYO CLINIC   (United States)

Author keywords

Association; Bias (epidemiology); Case control studies; Chi square statistic; Genes; Significance tests

Indexed keywords

ALLELE; ARTICLE; CASE CONTROL STUDY; COMPARATIVE STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETICS; HIGH RISK POPULATION; HOMOZYGOTE; STATISTICAL ANALYSIS;

EID: 0033561181     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.aje.a009878     Document Type: Article

References (21)

1. Begg CB, Berlin JA. Publication bias: a problem in interpreting medical data. J R Stat Soc [A] 1988;151:419-45.
2. Wacholder S, McLaughlin JK, Silverman DT, et al. Selection of controls in case-control studies. I. Principles. Am J Epidemiol 1992;135:1019-28.
3. Wacholder S, Silverman DT, McLaughlin JK, et al. Selection of controls in case-control studies. II. Types of controls. Am J Epidemiol 1992;135:1029-41.
4. Wacholder S, Silverman DT, McLaughlin JK, et al. Selection of controls in case-control studies. III. Design options. Am J Epidemiol 1992;135:1042-50.
5. Stefanski LA, Carroll RJ. Covariate measurement error in logistic regression. Ann Stat 1985;13:1335-51.
6. Falk CT, Rubinstein P. Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 1987;51:227-33.
7. Blum K, Nobel EP, Sheridan PJ, et al. Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 1990;263:2055-60.
8. Blum K, Noble EP, Sheridan PJ, et al. Association of the Al allele of the D dopamine receptor gene with severe alcoholism. Alcohol 1991;8:409-16.
9. Holden C. A cautionary genetic tale: the sobering story of D2. Science 1994;264:1696-7.
10. Gelernter J, Goldman D, Risch N. The Al allele at the D2 dopamine receptor gene and alcoholism. JAMA 1993;269:1673-7.
11. Pato CN, Macciardi F, Pato MT, et al. Review of the putatitve association of dopamine D, receptor and alcoholism: a meta-analysis. Am J Med Genet 1993;48:78-82.
12. Guo SW, Thompson EA. Performing the exact test of HardyWeinberg proportion for multiple alleles. Biometrics 1992;48:361-72.
13. Risch N. A general model for disease-marker association. Ann Human Genet 1983;47:245-52.
14. Thomson G. HLA disease associations: models for the study of complex human genetic disorders. Clin Rev Clin Lab Sci 1995;32:183-219.
15. Tiret L, Cambien F. Departure from Hardy-Weinberg Equilibrium should be systematically tested in studies of association between genetic markers and disease. (Letter). Circulation 1995;92:3364-5.
16. Sasieni PD. From genotypes to genes: doubling the sample size. Biometrics 1997;53:1253-61.
17. Weir BS. Genetic data analysis. Sunderland, MA: Sinauer Associates, Inc, 1990:34.
18. Ishigami T, Umemura S, Iwamoto T, et al. Molecular variant of angiotensinogen gene is associated with coronary atherosclerosis. Circulation 1995;91:951-4.
19. Li CC. First course in population genetics. Pacific Grove, CA: The Boxwood Press, 1976:522.
20. Hartl DL, Clark AG. Principles of population genetics. 2nd ed. Sunderland, MA: Sinauer Associates, Inc, 1989.
21. Armitage P. Tests for linear trends in proportions and frequencies. Biometrics 1955;11:375-86.