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Volumn 82, Issue 3, 2000, Pages 675-682

The role of p16-cyclin D/CDK-pRb pathway in the tumorigenesis of endometrioid-type endometrial carcinoma

Author keywords

CDK; Cyclin D; Endometrial cancer; p16(INK4); pRb

Indexed keywords

CYCLIN D; CYCLIN D1; CYCLIN D2; CYCLIN D3; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; NUCLEAR PROTEIN; PROTEIN P16; RETINOBLASTOMA PROTEIN;

EID: 0033967724     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.0980     Document Type: Article
Times cited : (80)

References (45)
  • 1
    • 0030889473 scopus 로고    scopus 로고
    • Expression of cyclin D1 correlates with malignancy in human ovarian tumours
    • Barbieri F, Cagnoli M, Ragni N, Pedulla F, Foglia G and Alama A (1997) Expression of cyclin D1 correlates with malignancy in human ovarian tumours. Br J Cancer 75: 1263-1268
    • (1997) Br J Cancer , vol.75 , pp. 1263-1268
    • Barbieri, F.1    Cagnoli, M.2    Ragni, N.3    Pedulla, F.4    Foglia, G.5    Alama, A.6
  • 2
    • 0030467624 scopus 로고    scopus 로고
    • The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis
    • Bartkova J, Lukas J, Guldberg P, Alsner J, Kirkin AF, Zeuthen J and Bartek J (1996) The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 56: 5475-5483
    • (1996) Cancer Res , vol.56 , pp. 5475-5483
    • Bartkova, J.1    Lukas, J.2    Guldberg, P.3    Alsner, J.4    Kirkin, A.F.5    Zeuthen, J.6    Bartek, J.7
  • 5
    • 0028820566 scopus 로고
    • LOH and mutation analysis of CDKN2 in primary human ovarian cancer
    • Campbell IG, Beynon G, Davis M and Englefield P (1995) LOH and mutation analysis of CDKN2 in primary human ovarian cancer. Int J Cancer 63: 222-225
    • (1995) Int J Cancer , vol.63 , pp. 222-225
    • Campbell, I.G.1    Beynon, G.2    Davis, M.3    Englefield, P.4
  • 6
    • 0029091503 scopus 로고
    • Frequency of homozygous deletion at p16/CDKN2 in primary human tumors
    • Cirns P et al (1995) Frequency of homozygous deletion at p16/CDKN2 in primary human tumors. Nat Genet 11: 210-212
    • (1995) Nat Genet , vol.11 , pp. 210-212
    • Cirns, P.1
  • 7
    • 0028980058 scopus 로고
    • Cyclins as markers of tumor proliferation: Immunocytochemical studies in breast cancer
    • Dutta A, Chandra R, Leiter LM and Lester S (1995) Cyclins as markers of tumor proliferation: immunocytochemical studies in breast cancer. Proc Natl Acad Sci USA 92: 5386-5390
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5386-5390
    • Dutta, A.1    Chandra, R.2    Leiter, L.M.3    Lester, S.4
  • 9
    • 0029893319 scopus 로고    scopus 로고
    • Cyclin D1 and prognosis in breast cancer
    • Gillett C et al (1996) Cyclin D1 and prognosis in breast cancer. Int J Cancer 69: 92-99
    • (1996) Int J Cancer , vol.69 , pp. 92-99
    • Gillett, C.1
  • 10
    • 0028875205 scopus 로고
    • Methylation of the 5′CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
    • Gnozalez-Zulueta M, Bender CM, Yang AS, Nguyen T, Beart RW, Van Tornout JM and Jones PA (1995) Methylation of the 5′CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55: 4531-4535
    • (1995) Cancer Res , vol.55 , pp. 4531-4535
    • Gnozalez-Zulueta, M.1    Bender, C.M.2    Yang, A.S.3    Nguyen, T.4    Beart, R.W.5    Van Tornout, J.M.6    Jones, P.A.7
  • 11
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
    • Hall M and Peters G (1996) Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 68: 67-108
    • (1996) Adv Cancer Res , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 13
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, Lapidus RG, Issa J-PJ, Davidson NE, Sidransky D and Baylin SB (1995) Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55: 4525-4530
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3    Lapidus, R.G.4    Issa, J.-P.J.5    Davidson, N.E.6    Sidransky, D.7    Baylin, S.B.8
  • 18
    • 0028940722 scopus 로고
    • Cell-cycle regulators and cancer
    • Kamb A (1995) Cell-cycle regulators and cancer. Trends Genet 11: 136-140
    • (1995) Trends Genet , vol.11 , pp. 136-140
    • Kamb, A.1
  • 21
    • 0028034775 scopus 로고
    • Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRB
    • Li Y, Nicholos MA, Shay JW and Xiong Y (1994) Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRB. Cancer Res 54: 6078-6082
    • (1994) Cancer Res , vol.54 , pp. 6078-6082
    • Li, Y.1    Nicholos, M.A.2    Shay, J.W.3    Xiong, Y.4
  • 23
    • 0028966582 scopus 로고
    • Sunlight and melanoma: An answer from MTS1 (p16)
    • Maestro R and Boiocchi M (1995) Sunlight and melanoma: an answer from MTS1 (p16). Science 267: 15-16
    • (1995) Science , vol.267 , pp. 15-16
    • Maestro, R.1    Boiocchi, M.2
  • 25
    • 0028953560 scopus 로고
    • Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squmaous cell carcinomas of the head and neck
    • Michalides R, van Veelen N, Hart A, Loftus B, Wientjens E and Balm A (1995) Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven operable squmaous cell carcinomas of the head and neck. Cancer Res 55: 975-978
    • (1995) Cancer Res , vol.55 , pp. 975-978
    • Michalides, R.1    Van Veelen, N.2    Hart, A.3    Loftus, B.4    Wientjens, E.5    Balm, A.6
  • 28
    • 0028829571 scopus 로고
    • Mechanism of inactivation of CDKN2 and MTS2 in non-small-cell lung cancer and association with advanced stage
    • Nakagawa K, Conrad NK, Williams JP, Johnson BE and Kelly MJ (1995) Mechanism of inactivation of CDKN2 and MTS2 in non-small-cell lung cancer and association with advanced stage. Oncogene 11: 1843-1851
    • (1995) Oncogene , vol.11 , pp. 1843-1851
    • Nakagawa, K.1    Conrad, N.K.2    Williams, J.P.3    Johnson, B.E.4    Kelly, M.J.5
  • 31
    • 0028951667 scopus 로고
    • Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival
    • Pietilainen T, Lipponen P, Aaltomaa S, Eskelinen M, Kosma VM and Syrjanen K (1995) Expression of retinoblastoma gene protein (Rb) in breast cancer as related to established prognostic factors and survival. Eur J Cancer 31A: 329-333
    • (1995) Eur J Cancer , vol.31 A , pp. 329-333
    • Pietilainen, T.1    Lipponen, P.2    Aaltomaa, S.3    Eskelinen, M.4    Kosma, V.M.5    Syrjanen, K.6
  • 32
    • 0030888284 scopus 로고    scopus 로고
    • Estrogen-induced activation of Cdk4 and Cdk3 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2
    • Prall OWJ, Sarcevic B, Musgrove EA, Watts CKW and Sutherland RL (1997) Estrogen-induced activation of Cdk4 and Cdk3 during G1-S phase progression is accompanied by increased cyclin D1 expression and decreased cyclin-dependent kinase inhibitor association with cyclin E-Cdk2. J Biol Chem 272: 10882-10894
    • (1997) J Biol Chem , vol.272 , pp. 10882-10894
    • Prall, O.W.J.1    Sarcevic, B.2    Musgrove, E.A.3    Watts, C.K.W.4    Sutherland, R.L.5
  • 33
    • 0028124330 scopus 로고
    • Cyclin D1 overexpression vs. retinoblastoma inactivation: Implications for growth control evasion in non-small and small cell lung cancer
    • Schauer IE, Siriwardana S, Langan TA and Sclafani RI (1994) Cyclin D1 overexpression vs. retinoblastoma inactivation: implications for growth control evasion in non-small and small cell lung cancer. Proc Natl Acad Sci USA 91: 7827-7831
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7827-7831
    • Schauer, I.E.1    Siriwardana, S.2    Langan, T.A.3    Sclafani, R.I.4
  • 34
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclinD/CDK4
    • Serrano M, Hannon GJ and Beach D (1993) A new regulatory motif in cell-cycle control causing specific inhibition of cyclinD/CDK4. Nature 366: 704-707
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 35
    • 0028988585 scopus 로고
    • Inhibitors of mammalian G1 cyclin-dependent kinases
    • Sherr CJ and Roberts JM (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Gene Dev 9: 1149-1163
    • (1995) Gene Dev , vol.9 , pp. 1149-1163
    • Sherr, C.J.1    Roberts, J.M.2
  • 39
    • 0028886364 scopus 로고
    • Unrestricted cell cycling and cancer
    • Strauss M, Lukas J and Bartek J (1995) Unrestricted cell cycling and cancer. Nat Med 1: 1245-1246
    • (1995) Nat Med , vol.1 , pp. 1245-1246
    • Strauss, M.1    Lukas, J.2    Bartek, J.3
  • 41
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81: 323-330
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 42
    • 0031897448 scopus 로고    scopus 로고
    • Infrequent mutation of the p16/MTS1 gene and overexpression of cyclin-dependent kinase 4 in human primary soft-tissue sarcoma
    • Yao J, Pollock RE, Lang A, Ming T, Pisters PWT, Goodrich D, El-Naggar A and Yu Dihua (1998) Infrequent mutation of the p16/MTS1 gene and overexpression of cyclin-dependent kinase 4 in human primary soft-tissue sarcoma. Clin Cancer Res 4: 1065-1070
    • (1998) Clin Cancer Res , vol.4 , pp. 1065-1070
    • Yao, J.1    Pollock, R.E.2    Lang, A.3    Ming, T.4    Pisters, P.W.T.5    Goodrich, D.6    El-Naggar, A.7    Yu, D.8
  • 44
    • 0031028265 scopus 로고    scopus 로고
    • Concurrent overexpression of cyclinD1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
    • Zhang T, Nanney LB, Luongo C, Lamps, Heppner KJ, DuBois RN and Beauchamp RD (1997) Concurrent overexpression of cyclinD1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res 51: 169-175
    • (1997) Cancer Res , vol.51 , pp. 169-175
    • Zhang, T.1    Nanney, L.B.2    Luongo, C.3    Lamps4    Heppner, K.J.5    DuBois, R.N.6    Beauchamp, R.D.7
  • 45
    • 0029025644 scopus 로고
    • Cyclin D1 (PRAD1) protein expression in breast cancer: Approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene
    • Zuberberg LR, Yang WI, Gadd M, Thor AD, Koerner FC, Schmidt EV and Arnold A (1995) Cyclin D1 (PRAD1) protein expression in breast cancer: approximately one-third of infiltrating mammary carcinomas show overexpression of the cyclin D1 oncogene. Mod Pathol 8: 560-566
    • (1995) Mod Pathol , vol.8 , pp. 560-566
    • Zuberberg, L.R.1    Yang, W.I.2    Gadd, M.3    Thor, A.D.4    Koerner, F.C.5    Schmidt, E.V.6    Arnold, A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.