The structure-activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 11, 2007, Pages 3938-3950

  Park, See Hyoung ^a   Oh, Hyun Sik ^b   Kang, Mi Ae ^a   Cho, Hyeongjin ^b   Prasad, Joshi Bishnu ^b   Won, Jonghwa ^a   Lee, Keun Hyeung ^b  

^a Mogam Biotechnology Research Institute   (South Korea)

^b Inha University   (South Korea)

Author keywords

Antagonist; Binding affinity; Inhibitor; Non peptide; SH2; T cell inhibition

Indexed keywords

2 (3,4 DIHYDROXYBENZOYLAMINO) 3 (3,4 DIHYDROXYPHENYL)PROPIONIC ACID METHYL ESTER; 2 [3 (3,4 DIHYDROXYPHENYL)ACRYLOYLAMINO] 3 (3,4 DIMETHOXYPHENYL)PROPIONIC ACID METHYL ESTER; 3 (3,4 DIHYDROXYPHENYL) 2 [2 (3,4 DIHYDROXYPHENYL)ACETYLAMINO]PROPIONIC ACID METHYL ESTER; 3 (3,4 DIHYDROXYPHENYL) 2 [3 (3 HYDROXY 4 METHOXYPHENYL)ACRYLOYLAMINO]PROPIONIC ACID METHYL ESTER; 3 (3,4 DIHYDROXYPHENYL) 2 [3 (3,4 DIHYDROXYPHENYL)ACRYLOYLAMINO]PROPIONIC ACID; 3 (3,4 DIHYDROXYPHENYL) 2 [3 (3,4 DIHYDROXYPHENYL)PROPIONYLAMINO]PROPIONIC ACID; 3 (3,4 DIHYDROXYPHENYL) 2 [3 (3,4 DIHYDROXYPHENYL)PROPIONYLAMINO]PROPIONIC ACID METHYL ESTER; 3 (3,4 DIHYDROXYPHENYL) 2 [3 (3,4 DIHYDROXYPHENYL)PROPIONYLOXY]PROPIONIC ACID; 3 (3,4 DIHYDROXYPHENYL) 2 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYLAMINO]PROPIONIC ACID METHYL ESTER; 3 (3,4 DIHYDROXYPHENYL) 2 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYLAMINO]PROPIONIC ACID METHYL ESTER; 3 (3,4 DIHYDROXYPHENYL)ACRYLIC ACID 1 TERT BUTOXYCARBONYL 2 (3,4 DIHYDROXYPHENYL)ETHYL ESTER; 3 (3,4 DIHYDROXYPHENYL)ACRYLIC ACID 2 (3,4 DIHYDROXYPHENYL) 1 (5 METHOXYCARBONYLPENTYLCARBAMOYL)ETHYL ESTER; 3 (3,4 DIHYDROXYPHENYL)ACRYLIC ACID 2 (3,4 DIHYDROXYPHENYL) 1 ETHOXYCARBONYLETHYL ESTER; 3 (3,4 DIHYDROXYPHENYL)ACRYLIC ACID 2 (3,4 DIHYDROXYPHENYL) 1 ISOPROPOXYCARBONYLETHYL ESTER; 3 (3,4 DIHYDROXYPHENYL)ACRYLIC ACID 2 (3,4 DIHYDROXYPHENYL) 1 METHOXYCARBONYLETHYL ESTER; 3 (3,4 DIHYDROXYPHENYL)ACRYLIC ACID 2 (3,4 DIHYDROXYPHENYL) 1 PROPOXYCARBONYLETHYL ESTER; INTERLEUKIN 2; NATURAL PRODUCT; PROTEIN INHIBITOR; PROTEIN SH2; ROSMARINIC ACID; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; IC 50; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CINNAMATES; DEPSIDES; HUMANS; JURKAT CELLS; SERINE PROTEINASE INHIBITORS; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES;

PRUNELLA VULGARIS;

EID: 34247503274     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.059     Document Type: Article

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