Enhancement of motility and acrosome reaction in human spermatozoa: Differential activation by type-specific phosphodiesterase inhibitors

Human Reproduction

Volumn 13, Issue 5, 1998, Pages 1248-1254

  Fisch, J D ^a   Behr, B ^a   Conti, M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acrosome reaction; Human spermatozoa; Motility; Phosphodiesterase inhibitors

Indexed keywords

CYCLIC AMP; METHYLXANTHINE DERIVATIVE; PHOSPHODIESTERASE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; RS 25344; UNCLASSIFIED DRUG;

ACROSOME REACTION; ARTICLE; CELL FRACTIONATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; HOMOGENATE; HUMAN; HUMAN CELL; MALE; SPERMATOZOON MOTILITY;

MAMMALIA;

EID: 0031864234     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/13.5.1248     Document Type: Article

References (25)

1. Aitken, R.J. (1997) Molecular mechanisms regulating human sperm function. Mol. Hum. Reprod., 3, 169-173.
2. Beavo, J. (1995) Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Am. J. Physiol., 75, 725-748.
3. Brennan, A. and Holden, C. (1995) Pentoxifylline-supplemented cryoprotectant improves human sperm motility after cryopreservation. Hum. Reprod.. 10, 2308-2312.
4. Conti, M., Nemoz, G., Sette, C. and Vicini, E. (1995) Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocrin. Rev., 16, 370-389.
5. De Jonge, C.J., Man, H.I., Lawrie, H. et al. (1991) Modulation of the human sperm the acrosome reaction by effectors of the adenylate cyclase/cyclic AMP second-messenger pathway. J. Exp. Zool., 258, 113-125.
6. De Lamirande, E., Leclerc, P. and Gagon, C. (1997) Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction. Mol. Hum. Reprod., 3, 175-194.
7. Horowitz, J.A., Toeg, H. and Orr, G.A. (1984) Characterization and localization of cAMP-dependent protein kinases in rat caudal epididymal sperm. J. Biol. Chem., 259, 832-838.
8. Hoskins, D.D., Hall, M.L. and Musterman, D. (1975). Induction of motility in immature bovine spermatozoa by cyclic AMP phosphodiesterase inhibitors and seminal plasma. Biol. Reprod., 13, 168-176.
9. Kramer, G.L., Garst, J.E., Mitchel, S.S. and Wells, J.N. (1977) Selective inhibition of cyclic nucleotide phosphodiesterases by analogues of 1-methyl3-isobutylxanthine. Biochemistry, 16, 3316-3321.
10. Lanzafame, F., Chapman, M.G., Guglielmino, A. et al. (1994) Pharmacological stimulation of sperm motility. Hum. Reprod., 9, 192-199.
11. Levin, R.M., Greenberg, S.H. and Wein, A.J. (1981) Quantitative analysis of the effects of caffeine on sperm motility and cyclic adenosine 3′, 5′monophosphate (AMP) phosphodiesterase. Fertil. Steril., 36, 798-802.
12. Mortimer, D., Curtis, E.F., Camenzind, A.R. and Tanaka, S. (1989) The spontaneous acrosome reaction of human spermatozoa incubated in vitro. Hum. Reprod., 4, 57-62.
13. Naro, F., Zhang, R. and Conti, M. (1996) Developmental regulation of unique adenosine 3′,5′-monophosphate-specific phosphodiesterase variants during rat spermatogenesis. Endocrinology, 137, 2464-2472.
14. Pang, S.C., Chan, P.J. and Lu, A. (1993) Effects of pentoxifylline on sperm motility and hyperactivation in normozoospermic and normokinetic semen. Fertil. Steril., 60, 336-343.
15. Rees, J.M., Ford, W.C.L. and Hull, M.G.R. (1990) Effect of caffeine and of pentoxifylline on the motility and metabolism of human spermatozoa. J. Reprod. Fertil., 90, 147-156.
16. Rossi, P., Pezzotti, R., Conti, M. and Geremia, R. (1985) Cyclic nucleotide phosphodiesterases in somatic and germ cells of mouse seminiferous tubules. J. Reprod. Fert., 74, 317-327.
17. Tash, J.S. and Means, A.R. (1982) Regulation of protein phosphorylation and motility of sperm by cyclic adenosine monophosphate and calcium. Biol. Reprod., 26, 745-763.
18. Tash, J.S. and Means, A.R. (1983) Cyclic adenosine 3′, 5′ monophosphate, calcium and protein phosphorylation in flagellar motility. Biol. Reprod., 28, 75-104.
19. Tesarik, J. (1989) Appropriate timing of the acrosome reaction is a major requirement for the fertilizing spermatozoon. Hum. Reprod., 4, 957-961.
20. Tesarik, J., Mendoza, C. and Carreras, A. (1992) Effects of phosphodiesterase inhibitors caffeine and pentoxifylline on spontaneous and stimulus-induced acrosome reactions in human sperm. Fertil. Steril., 58, 1185-1190.
21. Thompson, W.J. and Appleman, M.M. (1971) Multiple cyclic nucleotide phosphodiesterase activities from rat brain. Biochem. N.Y., 10, 311-316.
22. Visconti, P.E., Moore, G.D., Bailey, J.L. et al. (1995) Capacitation of mouse spermatozoa II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway. Development, 121, 1139-1150.
23. Yanagimachi, R. (1988) Mammalian fertilization. In Knobil, E. and Neill, J. (eds), The Physiology of Reproduction. Raven Press, New York, pp. 135-185.
24. Yovich, J.M., Edirisinghe, W.R., Cummins, J.M. and Yovich, J.L. (1990) Influence of pentoxifylline in severe male factor infertility. Fertil. Steril., 53, 715-722.
25. Zaneveld, L.J.D., De Jonge, C.J., Anderson, R.A. and Mack, S.R. (1991) Human sperm capacitation and the acrosome reaction. Hum. Reprod., 6, 1265-1274.