Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function

Fertility and Sterility

Volumn 81, Issue 4, 2004, Pages 1026-1033

  Du Plessis, Stefan S ^a   De Jongh, Paul S ^a   Franken, Daniel R ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

8 Bromo cGMP; Acrosome; Human spermatozoa; Morphology; Motility; Semen; Sildenafil citrate; VIAGRA; Zona pellucida

Indexed keywords

8 BROMO CYCLIC GMP; PLACEBO; SILDENAFIL;

ACROSOME REACTION; ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ELECTROCARDIOGRAM; HUMAN; MALE; NORMAL HUMAN; OOCYTE; PARAMETER; PENIS ERECTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPERM; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TREATMENT FAILURE; VOLUNTEER; ZONA PELLUCIDA;

ACROSOME REACTION; ADULT; BIOMECHANICS; CROSS-OVER STUDIES; CYCLIC GMP; DOUBLE-BLIND METHOD; HUMANS; MALE; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; SEMEN; SPERM MOTILITY; SPERM-OVUM INTERACTIONS; SPERMATOZOA; ZONA PELLUCIDA;

EID: 1842526941     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2003.09.054     Document Type: Article

References (44)

1. Feldman H.A., Goldstein I., Hartzichristou D.G., Krane R.J., McKinlay J.B. Impotence and its medical and psychosocial correlates results of the Massachusetts Male Aging Study. J Urol. 151:1994;54-61.
2. Purvis K., Muirhead G.J., Harness J.A. The effects of sildenafil citrate on human sperm function in healthy volunteers. Br J Clin Pharmacol. 53:2002;53S-60S.
3. Boolell M., Gepi-Attee S., Gingell J.C., Allen M.J. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br J Urol. 78:1996;257-261.
4. Boolell M., Allen M.J., Ballard S.A., Gepi-Attee S., Muirhead G.J., Naylor I.H., et al. Sildenafil an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 8:1996;47-52.
5. Conti M., Nemoz G., Sette C., Vicini E. Recent progress in understanding the hormonal regulation of phosphodiesterases. Endocr Rev. 16:1995;370-389.
6. Rascon A., Soderling S.H., Schaefer J.B., Beavo J.A. Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B)f from Trypanosoma brucei. Proc Natl Acad Sci USA. 99:2002;4714-4719.
7. Fabbri A., Aversa A., Isidori A. Sildenafil and erectile dysfunction. J Endocrinol Invest. 22:1999;486-491.
8. Lewis S.E., Donnely E.T., Sterling E.S., Kennedy M.S., Thompson W., Chakravarthy U. Nitric oxide synthase and nitrite production in human spermatozoa evidence that endogenous nitric oxide is beneficial to sperm motility. Mol Hum Reprod. 2:1996;873-878.
9. Fisch J.D., Behr B., Conti M. Enhancement of motility and acrosome reaction in human spermatozoa differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod. 13:1998;1248-1254.
10. Naro F., Zang R., Conti M. Developmental regulation of unique adenosine 3′-5′-monophosphate-specific phosphodiesterase variants during rat spermatogenesis. Endocrinology. 137:1996;2464-2472.
11. Soderling S.H., Bayuga S.J., Beavo J.A. Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem. 273:1998;15553-15558.
12. Ballard S.A., Gingell C.J., Tang K., Turner L.A., Price M.E., Naylor A.M. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol. 159:1998;2164-2171.
13. Glossman H., Petrischor G., Bartsch G. Molecular mechanisms of the effects of sildenafil (VIAGRA). Exp Gerontol. 34:1999;305-318.
14. Morales A., Gingell C., Collins M., Wicker P.A., Osterloh I.H. Clinical safety of oral sildenafil citrate (VIAGRA) in the treatment of erectile dysfunction. Int J Impot Res. 10:1998;69-74.
15. Fabbri A., Aversa A., Isidori A. Erectile dysfunction an overview. Hum Reprod Update. 3:1997;455-466.
16. Goldstein I., Lue T.F., Padma-Nathan H., Rosen R.C., Steers W.D., Wicker P.A. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med. 338:1998;1397-1404.
17. Nichols D.J., Muirhead G.J., Harness J.A. Pharmacokinetics of sildenafil citrate after single oral doses in healthy male subjects absolute bioavailability, food effects and dose proportionality. Br J Clin Pharmacol. 53:2002;5S-12S.
18. Tur-Kaspa I., Segal S., Moffa M., Massobrio M., Meltzer S. VIAGRA for temporary erectile dysfunction during treatments with assisted reproductive technologies case report. Hum Reprod. 14:1999;1783-1784.
19. Pichini S., Zuccaro P., Pacifi R. Drugs in semen. Clin Pharmacokinet. 26:1994;356-373.
20. Schoenfeld C., Amelar R.D., Dublin L. Stimulation of ejaculated human spermatozoa by caffeine. Fertil Steril. 26:1975;158-161.
21. Turner E.A., De Aparicio N.J., Turner D., Schwartstein L. Effect of two phosphodiesterase inhibitors, cyclic adenosine 3′,5′-monophosphate, and a beta-blocking agent on human sperm motility. Fertil Steril. 29:1978;328-331.
22. Shen M.R., Chiang P.H., Yang R.C., Hong C.Y., Chen S.S. Pentoxifylline stimulates human sperm motility both in vitro and after oral therapy. Br J Clin Pharmacol. 31:1991;711-714.
23. Edwards G., Muirhead G.J. Introduction to supplement. J Clin Pharmacol. 53:2002;1-3S.
24. World Health Organization. WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction. 4th ed:1999;Cambridge University Press, New York.
25. Quin P., Kerin J.F., Warnes G.M. Improved pregnancy rate in human in vitro fertilization with the use of a medium base on the composition of human tubal fluid. Fertil Steril. 44:1985;493-498.
26. Mahedevan M., Trounson A. Effect of cryoprotective media and dilution methods on the preservation of human spermatozoa. Andrologia. 15:1993;355-366.
27. Kruger T.F., Menkveld R., Stander F.S.H., Lombard C.J., Van der Merwe J.P., Van Zyl J.A., et al. Sperm morphologic features as a prognostic factor in in vitro fertilization. Fertil Steril. 46:1986;1118-1123.
28. Hammit D.G., Syrop C.H., Walker D.L., Bennet M.R. Conditions of oocyte storage and use of non inseminated, non-fertilized oocytes for the hemizona assay. Fertil Steril. 60:1991;131-136.
29. Cross N.L., Morales P., Overstreet J.W., Hanson F.W. Induction of acrosome reactions by the human zona pellucida. Biol Reprod. 38:1988;235-244.
30. Morales P., Cross N.L., Overstreet J.W., Hanson F.W. Acrosome-intact and acrosome-reacted human sperm can initiate binding to the zona pellucida. Dev Biol. 133:1989;385-392.
31. Franken D.R., Bastiaan H.S., Oehninger S.C. Physiological induction of the acrosome reaction in human sperm validation of a micro-assay using minimal volumes of solubilised, homologous zona pellucida. J Assist Reprod Gen. 17:2000;156-161.
32. Aversa A., Mazzilli F., Rossi T., Delfino M., Isidori A.M., Fabbri A. Effects of sildenafil administration on seminal parameters and post-ejaculatory refractory time in normal males. Hum Reprod. 15:2000;131-134.
33. Rotem R., Zamir N., Keynan N., Barkan D., Breitbart H., Naor Z. Atrial natriuretic peptide induces acrosomal exocytosis of human spermatozoa. AJP. 274:1998;E218-223.
34. Revelli A., Costamagna C., Moffa F., Aldieri E., Ochetti S., Bosia A., et al. Signalling pathways of nitric oxide-induced acrosome reaction in human spermatozoa. Biol Reprod. 64:2001;1708-1712.
35. Lincoln T.H., Cornwell T.L. Intracellular cyclic GMP receptor proteins. FASEB J. 7:1993;328-338.
36. Lefiévre L., De Lamirande E., Gagnon C. The cyclic GMP-specific phosphodiesterase inhibitor sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction. J Androl. 21:2000;929-937.
37. Burger M., Sikka S.C., Bivalacqua T.J., Lamb D.J., Hellstrom W.F.G. The effect of sildenafil on human sperm motion and function from normal and infertile men. Int J Impot Res. 12:2000;229-234.
38. Cuadra D.L., Chan P.J., Patton W.C., Stewart S.C., King A. Type 5 phosphodiesterase regulation of human sperm motility. Am J Obstet Gynecol. 182:2000;1013-1015.
39. Ozgür K., Franken D.R. The influence of sperm/zona pellucida collision rates on zona binding. Andrologia. 28:1996;261-265.
40. Calogero A.E., Fishel S., Hall J., Ferrara E., Vicari E., Green S., et al. Correlation between intracellular cAMP content, kinematic parameters and hyperactivation of human spermatozoa after incubation with pentoxifylline. Hum Reprod. 13:1998;911-915.
41. Nassar A., Mahoney M., Morshedi M., Lin M.H., Srisombut C., Oehninger S. Modulation of sperm tail protein tyrosine phosphorylation by pentoxifylline and its correlation with hyperactivation and motility. Fertil Steril. 71:1999;919-923.
42. Cheng C.Y., Boettcher B. Effect of cAMP, Mn2+ and phosphodiesterase inhibitors on human sperm motility. Arch Androl. 7:1981;313-317.
43. Leclerc P., de Lamirande E., Gagnon C. Cyclic adenosine 3′, 5′ monophosphate-dependent regulation of protein tyrosine phosphorylation in relation to human sperm capacitation and motility. Biol Reprod. 55:1996;684-692.
44. Yanagimachi R. Mammalian fertilization. Knobil E., Neil J.D. The physiology of reproduction. Vol 1. 2nd ed:1994;189-317 Raven Press, New York.