Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology

International Journal of Impotence Research

Volumn 17, Issue 3, 2005, Pages 216-223

  Wayman, C ^a   Phillips, S ^a   Lunny, C ^a   Webb, T ^a   Fawcett, L ^a   Baxendale, R ^a   Burgess, G ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Fertility; PDE11; Spermatozoa; Tadalafil

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 11; SILDENAFIL; TADALAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; FERTILIZATION; HYDROLYSIS; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROSTATE; PROTEIN EXPRESSION; SPERMATOGENESIS; SPERMATOZOON; SPERMATOZOON CAPACITATION; SPERMATOZOON DENSITY; SPERMATOZOON MOTILITY; TESTIS;

ANIMALS; CYCLIC AMP; CYCLIC GMP; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORIC DIESTER HYDROLASES; PROSTATE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SPERM CAPACITATION; SPERM COUNT; SPERM MOTILITY; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TRANSFECTION;

EID: 18744409801     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3901307     Document Type: Article

References (34)

1. Visconti PE, Kopf GS. Regulation of protein phosphorylation during sperm capacitation. Biol Reprod 1998; 59: 1-6.
2. Chang M. Fertilization capacity of spermatozoa deposited into the fallopian tubes. Nature 1951; 168: 697-698.
3. Chang M. Development of fertilizing capacity of rabbit spermatozoa in the uterus. Nature 1955; 175: 1036-1037.
4. Austin C. Observations on the penetration of the sperm into the mammalian egg. Austr J Sci Res 1951; 4: 581-596.
5. Austin C. The 'capacitation' of the mammalian sperm. Nature 1952; 170: 326.
6. Nantel F et al. Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice. Nature 1996; 380: 159-162.
7. Sinclair ML et al. Specific expression of soluble adenylyl cyclase in male germ cells. Mol Reprod Dev 2000; 56: 6-11.
8. Baxendale RW, Fraser LR. Evidence for multiple distinctly localized adenylyl cyclase isoforms in mammalian spermatozoa. Mol Reprod Dev 2003; 66: 181-189.
9. Breitbart H. Intracellular calcium regulation in sperm capacitation and acrosomal reaction. Mol Cell Endocrinol 2002; 187: 139-144.
10. de Lamirande E, Leclerc P, Gagnon C. Capacitation as a regulatory event that primes spermatozoa for the acrosome reaction and fertilization. Mol Hum Reprod 1997; 3: 175-194.
11. Soderling SH, Beavo JA. Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol 2000; 12: 174-179.
12. Francis SH, Turko IV, Corbin JD. Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol 2001; 65: 1-52.
13. Conti M, Jin SL. The molecular biology of cyclic nucleotide phosphodiesterases. Prog Nucleic Acid Res Mol Biol 1999; 63: 1-38.
14. Jin SL et al. Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc Natl Acad Sci USA 1999; 98: 11998-12003.
15. Masciarelli S et al. Cyclic nucleotide phosphodiesterase 3A-deficient mice as a model of female infertility. J Clin Invest 2004; 114: 196-205.
16. Fawcett L et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA 2000; 97: 3702-3707.
17. Hetman JM et al. Cloning and characterization of two splice variants of human phosphodiesterase 11A. Proc Natl Acad Sci USA 2000; 97: 12891-12895.
18. Hogan B, Beddington R, Costantini F, Lacy E. Manipulating the Mouse Embryo, A Laboratory Manual, 2nd edn. Cold Spring Harbor Press: Cold Spring Harbor, NY, USA, 1994, pp 253-290.
19. Stewart CL. Production of chimeras between embryonic stem cells and embryos. Methods Enzymol 1993; 225: 823-855.
20. Fraser LR, Harrison RA, Herod JE. Characterization of a decapacitation factor associated with epididymal mouse spermatozoa. J Reprod Fertil 1990; 89: 135-148.
21. Fraser LR, Adeoya-Osiguwa S. Modulation of adenylyl cyclase by FPP and adenosine involves stimulatory and inhibitory adenosine receptors and g proteins. Mol Reprod Dev 1999; 53: 459-471.
22. Gresser U, Gleiter CH. Erectile dysfunction: comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil-review of the literature. Eur J Med Res 2002; 7: 435-446.
23. Pomara G et al. Effect of acute in vivo sildenafil or tadalafil treatments on semen parameters in patients with fertility problem, a randomized, doouble-blind, crossover study. J Sex Med 2004; 2(Suppl 2): 23(PS-5-9).
24. Lefievre L, De Lamirande E, Gagnon C. The cyclic GMP-specific phosphodiesterase inhibitor, sildenafil, stimulates human sperm motility and capacitation but not acrosome reaction. J Androl 2000; 21: 929-937.
25. Du Plessis SS, De Jongh PS, Franken DR. Effect of acute in vivo sildenafil citrate and in vitro 8-bromo-cGMP treatments on semen parameters and sperm function. Fertil Steril 2004; 81: 1026-1033.
26. Hellstrom WJ et al. Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones. J Urol 2003; 170: 887-891.
27. Weeks JL et al. High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients. Int J Impot Res 2005; 17: 5-9.
28. Spehr M et al. Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science 2003; 299: 2054-2058.
29. Ren D et al. A sperm ion channel required for sperm motility and male fertility. Nature 2001; 413: 603-609.
30. Quill TA, Ren D, Clapham DE, Garbers DL. A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci USA 2001; 98: 12527-12531.
31. 2+ entry and control of flagellar function in sperm. Proc Natl Acad Sci USA 2003; 100: 14864-14868.
32. Baxendale RW, Fraser LR. Immunolocalization of multiple Galpha subunits in mammalian spermatozoa and additional evidence for Galphas. Mol Reprod Dev 2003; 65: 104-113.
33. Esposito G et al. Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect. Proc Natl Acad Sci USA 2004; 101: 2993-2998.
34. Spehr M et al. Particulate adenylate cyclase plays a key rolo in human sperm olfactory receptor-mediated chemotaxis. J Biol Chem 2004; 279: 40194-40203.