Type 5 phosphodiesterase regulation of human sperm motility

American Journal of Obstetrics and Gynecology

Volumn 182, Issue 5, 2000, Pages 1013-1015

  Cuadra, Deborah L ^a   Chan, Philip J ^a   Patton, William C ^a   Stewart, Steven C ^a   King, Alan ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acrosome reaction; Cyclic guanosine monophosphate; Human spermatozoa; Phosphodiesterase

Indexed keywords

CYCLIC GMP; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL;

ACROSOME REACTION; ARTICLE; COLONY FORMATION; DRUG EFFECT; ENZYME INHIBITION; ENZYME REGULATION; FERTILIZATION; GENETIC LINKAGE; HUMAN; HUMAN CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTO ONCOGENE; SEMEN ANALYSIS; SPERMATOZOON MOTILITY;

EID: 0034084402     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1067/mob.2000.105435     Document Type: Article

References (5)

1. 1. Santos-Sacchi J, Gordon M. Induction of the acrosome reaction in guinea pig spermatozoa by cGMP analogues. J Cell Biol 1980;85:798-803.
2. 2. Chan YM, Chan SY, Tucker MJ, Wong CJ, Leung CK, Leong MK. Effects of dibutyryl cyclic guanosine monophosphate on human spermatozoal motility and penetration of zona-free hamster oocytes. Hum Reprod 1990;5:304-8.
3. 3. Fisch JD, Behr B, Conti M. Enhancement of motility and acrosome reaction in human spermatozoa: differential activation by type-specific phosphodiesterase inhibitors. Hum Reprod 1998;13:1248-54.
4. 4. Ballard SA, Gingell CJ, Tang K, Turner LA, Price ME, Naylor AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol 1998;159:2164-71.
5. 5. Chan PJ, Corselli JU, Jacobson JD, Patton WC, King A. Correlation between intact sperm acrosome assessed using the Spermac stain and sperm fertilizing capacity. Arch Androl 1996;36:25-7.