Effects of L-carnitine on RBC membrane composition and function in hyperinsulinemic rats

Italian Journal of Biochemistry

Volumn 56, Issue 1, 2007, Pages 53-60

  Rajasekar, P ^a   Balasaraswathi, K ^a   Anuradha, C V ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Erythrocyte (RBC) membrane; Fructose; Glycoproteins; Hyperinsulinemia; L carnitine; Membrane bound ATPases; RBC lipid peroxidation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CARNITINE; FRUCTOSE; FUCOSE; HEXOSAMINE; HEXOSE; N ACETYLNEURAMINIC ACID;

ANIMAL; ARTICLE; BLOOD; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DRUG EFFECT; ERYTHROCYTE MEMBRANE; HYPERINSULINISM; MALE; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; RAT; WISTAR RAT;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CARNITINE; ERYTHROCYTE MEMBRANE; FRUCTOSE; FUCOSE; HEXOSAMINES; HEXOSES; HYPERINSULINISM; MALE; N-ACETYLNEURAMINIC ACID; OXIDATIVE STRESS; RATS; RATS, WISTAR;

ANIMALIA; RATTUS;

EID: 34247492527     PISSN: 00212938     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Anitha Nandhini, AT, Balakrishnan, SD, Anuradha, CV, Response of liver antioxidant system to taurine in rats fed high fructose diet, Ind. J. Exp. Biol, 2002, 40, 1016-1019.
2. Anuradha, CV, Balakrishnan, SD, Menon, VP, Increased erythrocyte lipid peroxidation and osmotic fragility in sports people, Med. Sci. Res, 1995, 23, 409-412.
3. Arduini, A, Rossi, M, Mancinelli, G, Belfiglio, M, Scurti, R, Radatti, G, Shohet, SB, Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability, Life Sci, 1990, 47, 2395-2400.
4. Arduini, A, Carnitine and its acyl esters as secondary antioxidants? Am. Heart J, 1992, 123, 1726-1727.
5. Arockiyarani, JP, Panneerselvam, C, Carnitine as a free radical scavenger in aging, Exp. Gerontol, 2001, 36, 1713-1726.
6. Baker, H, Frank, O, De Angelis, B, Feingold, S, Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol, Nutr. Rep. Int. 1980, 21, 531-536.
7. Bonting, SL, Presence of enzyme system in mammalian tissues, In: Bilter EE (editor). Membrane and Ion Transport, London. Wiley Inter Science, p257-263, 1970.
8. Borochov, H, Abbott, RE, Schachter, D, Shinitzky, M, Modulation of erythocyte membrane protein by membrane cholesterol and lipid fluidity, Biochemistry, 1979, 18, 251-255.
9. Broderick, TL, Quinuey, HA, Lopaschuk, GD, Carnitine stimulation of glucose oxidation in the fatty acid perfused isolated working rat heart, J. Biol. Chem, 1992, 267, 3758-3763.
10. Busserolles, J, Gueux, E, Rock, E, Mazur, A, Rayssiguier, Y, Substituting honey for refined carbohydrates protects rats from hypertriglyceridemic and prooxidative effects of fructose, J. Nutr, 2002, 11, 3379-3382.
11. Cynamon, HA, Isenberg, JN, Naguyean, CH, Erythrocyte malondialdehyde release. in vitro: a functional measure of vitamin E status, Clin. Chem. Acta, 1985, 151, 169-176.
12. Dai, S, Todd, ME, Lee, S, Mc Neill, JH, Fructose loading induces cardiovascular and metabolic changes in non-diabetic and diabetic rats, Can. J. Physiol. Pharmacol, 1994, 72, 771-781.
13. Dayanandan, A, Kumar, P, Panneerselvam, C, Protective role of L-camitine on liver and heart lipid peroxidation in atherosclerotic rats, J. Nutr. Biochem. 2001, 12, 254-257.
14. de los Reyes, B, Navarro, JA, Perez-Garcia, R, Liras, A, Campos, Y, Bornstein, B, Arenas, J, Effects of L-carnitine on erythrocyte acyl-CoA, free CoA, and glycerophospholipid acyltransferase in uremia, Am. J. Clin. Nutr, 1998, 67, 386-390.
15. Derosa, G, Cicero, AFG, Gaddi, A, Mugellini, A, Ciccarelli, L, Fogari, R, The effect of camitine on plasma lipoprotein (a) levels in hypercholesterolemic patients with type 2 diabetes mellitus, Clin. Ther, 2003, 25, 1429-1439.
16. Dische, Z, Shettles, LB, Special colorimetric reaction of methyl pentoses and a spectrophotometric micromethod for their determination, J. Biol. Chem, 1948, 175, 595-604.
17. Dodge, JT, Mitchell, G, Hanaban, DJ, The preparation and chemical characteristics of haemoglobin free ghosts of human red cells, Arch. Biochem. Biophys, 1963, 180, 119-130.
18. Evans, DJ, Membrane adenosine triphosphatase of E. Coli. activation by calcium ions and inhibition by monovalent cations, J. Bacteriol, 1969, 100, 914-922.
19. Falholt, K, Falholt, W, Lund, B, An easy colorimetric method for routine determination of free fatty acids in plasma, Clin. Chem. Acta, 1973, 46, 105.
20. Farielo, RG, Ferrano, TG, Golden, GT, Demattei, M, Systemic acetyl-L-carnitine elevates nigral levels of glutathion and GABA, Life Sci, 1988, 43, 289-292.
21. Faure, P, Rossini, E, Lafond, JL, Richard, MJ, Favier, A, Halimi, S, Vitamin E improves the free radical defense system potential and insulin sensitivity of rats fed high fructose diets, J. Nutr, 1997, 127, 103-107.
22. Fields, M, Lavis, CG, Lore, M, Antholine, WS, The influence of gender on developing copper deficiency and on free radical generation of rats fed a fructose diet, Metabolism, 1992, 41, 989-994.
23. Folch, J, Lees, M, Stanley, GSH, A simple method for the isolation and purification of total lipids from animal tissue, J. Biol. Chem, 1951, 126, 497-509.
24. Groenen, OJ, Merck, KB, de Jong, WW, Bloemendal, H, Structure and modifications of the junior chaperone alpha-crystallin. From lens transparency to molecular pathology, Eur. J. Biochem, 1994, 225, 365-383.
25. 2+-ATPase from erythrocyte membranes, Biochem. Biophys. Acta, 1983, 728, 281-288.
26. Jain, SK, Me Vie, R, Duett, J, Herbst, JJ, Erythrocyte membrane lipid peroxidation and glycosylate hemoglobin in diabetes, Diabetes, 1989, 28, 1539-1543.
27. Jiang, Z, Hunt, J, Wolff, S, Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low-density lipoprotein, Anal, Biochem, 1992, 202, 384-389.
28. Kalaiselvi, CJ, Panneerselvam, C, Effect of L-carnitine on the status of lipid peroxidation and antioxidants in aging rats, J. Nutr. Biochem, 1998, 9, 575-581.
29. Kasim-Karakas, SE, Vriend, H, Almario, R, Chow, LC, Goodman, MN, Effects of dietary carbohydrates on glucose and lipid metabolism in golden Syrian hamsters, J. Lab. Clin. Med, 1996, 128, 208-213.
30. Kreis, R, Jung, B, Rotman, S, Slotboom, J Boesch, C, Non-invasive observation of acetyl-group buffering by 1H-MR spectroscopy in exercising human muscle. NMR Biomed, 1999, 12, 471-476.
31. Labonia, WD, Morelli, OH Jr, Gimenez, Ml, Freuler, PV, Morelli, OH, Effect of L-carnitine on sodium transport in erythrocytes from dialyzed uremic patients, Kidney Int, 1987, 32, 754-759.
32. Leighton James, AKM, Bhuiyan, J, Foster, D, Seccombe, D, Effect of L-Carnitine Treatment on very low density lipoprotein kinetics in the hyperlipidemic rabbit, Clinical Biochemistry, 1995, 28, 451-458.
33. Lindberg, G, Eklund, GA, Gullberg, B, Rastam, L, Serum sialic acid concentration and cardiovascular mortality, Br. Med. J, 1991, 302, 143-146.
34. Lowry, OH, Rosebrough, NJ, Farr, AL, Randall, RJ, Protein measurement with the Folin's-Phenol reagent, J. Biol. Chem, 1951, 193, 265-275.
35. Mingrone, G, Greco, AV, Capristo, E, Benedetti, G, Giancaterini, A, De Gaetano, A, Gasbarrini, GJ, Carnitine improves glucose disposal in type 2 diabetic patients. Am. Coll. Nutr, 1999, 18, 77L-82L.
36. Niebes, P, Determination of enzymes and degradation in products of glycosaminoglycan metabolism in the serum of healthy and varicose subjects, Clin. Chim. Acta, 1972, 42, 399-408.
37. Niehaus, WG Jr, Samuelsson, B, Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation, Eur. J. Biochem, 1968, 6, 126-130.
38. 2+-ATPase activities in normal, regenerating and malignant cells, Biochem. Biophys. Acta, 1982, 684, 67-74.
39. Peluso, G, Petillo, O, Barbarisi, A, Melone, MAB, Reda, E, Nicolai, R, Calvani, M, Carnitine protects the molecular chaperone activity of lens α-crystallin and decreases the posttranslational protein modifications induced by oxidative stress, FASEB J, 2001, 15, 1604-1606.
40. +- ATPase activity, metabolic control and neuropathy in IDDM patients, Diabetes care, 1996, 19, 564-568.
41. Rajasekar, P, Ravichandran, MK, Anuradha, CV, Intraperitoneal L-carnitine regulates lipid metabolism and reduces oxidative stress in fructose-induced hyperlipidemic rats, Diabetol. Croat, 2006, 34, 87-95.
42. Rajasekar, P, Kaviarasan, S, Anuradha, CV, L-Carnitine administration prevents oxidative stress in high fructose-fed insulin resistant rats, Diabetol. Croat, 2005, 34, 21-28.
43. Reaven, GM, Insulin resistance, hyperinsulinemia, hyperteriglyceridemia and hypertension: parallels between human disease and rodent models, Diabetes Care/Rev, 1991, 14, 195-202.
44. Sailaja, YR, Baskar, R, Saralakumari, D, The antioxidant status during the maturation of reticulocytes to erythrocytes in type 2 diabetics, Free Radical Biol. Med, 2003, 35, 133-139.
45. Sushamakumari, S, Jayadeep, A Sureshkumar, JS, Venugopal, PM, 1989, Effect of carnitine in malondialdehyde taurine and glutathione levels in heart of rats subjected to myocardial stress by isoproterenol, Ind. J. Exp. Biol, 1989, 27, 134-137.
46. Swamy-Mruthinti, S, Carter, AL, Acetyl-carnitine decreases glycation of lens proteins: invitro studies, Exp. Eye Res, 1999, 69, 109-115.
47. Tay, A, Ozcelikay, AT, Altan, VM, Effects of L-arginine on blood pressure and metabolic changes in fructose-hypertensive rats, Am. J. Hypertension, 2002, 15, 72-77.
48. Tettamauti, G, Bonali, F, Marchesini, S, Zambothi, V, A new procedure for extraction purification and fractionation of brain gangliosides, Biochim. Biophys. Acta, 1973, 296, 160-170.
49. Thirunavukkarasu, V, Anuradha, CV, Influence of α-lipoic acid on lipid peroxidation and antioxidant defense system in blood of insulin resistant rats, Diab. Obes. Metabol, 2004, 6, 200-207.
50. Virmani, AF, Gaetani, S, Imam, Z, Binienda, and S. Ali, Possible mechanism for the neuroprotective effects of L-carnitine on methamphetamine- evoked neurotoxicity, Ann. N. Y. Acad. Sci, 2003, 993, 197-207.
51. Virmani, A, Caso, V, Spadoni, A, Rossi, S, Russo, F, Gaetani, F, The action of acetyl-Lcarnitine on the neurotoxicity evoked by amyloid fragments and peroxide on primary rat cortical neurons, Ann. N.Y. Acad. Sci, 2001, 939, 162-178.
52. Wagner, WD, A more sensitive assay discriminating galactosamine and glucosamine in mixtures. Anal. Biochem, 1979, 94, 394-396.
53. Zilversmit, DB, Davis, AK, Microdetermination of plasma phospholipids by trichloroacetic acid precipitation, J. Lab Clin. Invest, 1950, 35, 155.
54. Zlatki, A, Zak, B, Boyle, AJ, A new method for the direct determination of serum cholesterol. J. Lab Clin. Med, 1953, 45, 486