The action of acetyl-L-carnitine on the neurotoxicity evoked by amyloid fragments and peroxide on primary rat cortical neurones

Annals of the New York Academy of Sciences

Volumn 939, Issue , 2001, Pages 162-178

  Virmani, M Ashraf ^a   Caso, V ^a   Spadoni, A ^a   Rossi, S ^a   Russo, F ^a   Gaetani, F ^a  

^a Sigma Tau SpA   (Italy)

Author keywords

A interaction; Acetyl L carnitine; Alzheimer's; Amphiphilic; Amyloid; Antioxidant; Binding sites; Charged anionic phospholipids; Diabetes; Down's; Fluidity; Lipid peroxidation; Macular degeneration; Membrane; Membrane stabilization; Metabolic compromise; Mitochondria; MTT response; Neurodegeneration; Neurotoxicity; Permeability; Peroxidase; Zwitterion

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; CATALASE; CYCLOHEXIMIDE; GLUTATHIONE; LEVACECARNINE; NERVE GROWTH FACTOR; PEROXIDE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN CELL; CELL VIABILITY; CONFERENCE PAPER; DIABETES MELLITUS; DOWN SYNDROME; MITOCHONDRION; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; RETINA MACULA DEGENERATION;

EID: 0034937436     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb03623.x     Document Type: Conference Paper

References (60)

1. Mitochondrial damage, environmental factors and aging: Acetyl-L-carnitine as a protective factor
2. The relation of oxidative stress and hyperexcitation to neurological disease
3. Mitochondria in neurodegeneration: Acute ischemia and chronic neurodegenerative diseases
4. Effect of acetyl-L-carnitine on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity
5. Prevention of post-ischemic molecular alterations and neurological injury by acetyl-L-carnitine
6. Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine
7. Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncopuling or inhibitors
8. Acetyl-L-carnitine effects on nerve conduction and glycemic regulation in experimental diabetes
9. Culture of dorsal root ganglion neurons from aged rats. Effects of acetyl-L-carnitine and NGF
10. Motonuclear changes after cranial nerve injury and regeneration
11. Alteration of voltage-dependent calcium channels in canine brain during global ischemia and reperfusion
12. Autoradiographic analysis of L- and N-type voltage-dependent calcium channel binding in canine brain after global cerebral ischemia/reperfusion
13. L-Acetylcarnitine attenuates the age dependent decrease of NMDA sensitive glutamate receptors in rat hippocampus
14. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain
15. Carnitine: Metabolism and function
16. Stabilising action of carnitine on energy linked processes in rat liver mitochondria
17. Protective effect of carnitine on lipoperoxide formation in rat brain
18. Protective effect of L-carnitine in the neurotoxicity induced by the mitochondrial inhibitor 3-nitropropionic acid (3-NPA)
19. Action of acetyl-L-carnitine on the neurotoxicity evoked by amyloid fragments on primary rat cortical neurones
20. Tests for evaluating the potential toxic effects of compounds on the neuroendocrine system
21. The intracellular component of cellular 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) reduction is specifically inhibited by beta-amyloid peptides
22. Aggregation state and neurotoxic properties of Alzheimer beta-amyloid peptide
23. Neuroprotective approaches in experimental models of beta-amyloid neurotoxicity: Relevance to Alzheimer's disease
24. Structure-activity analyses of beta-amyloid peptides: Contributions of the beta 25-35 region to aggregation and neurotoxicity
25. An artifact associated with using trypan blue exclusion to measure effects of amyloid beta on neuron viability
26. Beta-amyloid-mediated inhibition of redox activity (MTT reduction) is not an indicator of astroglial degeneration
27. Inhibition of the electrostatic interaction between beta-amyloid peptide and membranes prevents beta-amyloid-induced toxicity
28. Steroid hormones block amyloid fibril-induced 3-(4,5-dimethylthiazol-2-y1)-2,5-diphenyltetrazolium bromide (MTT) formazan exocytosis: Relationship to neurotoxicity
29. Neurotoxicity of beta-amyloid
30. Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: Role of the lipid peroxidation product 4-hydroxynonenal
31. Both oxidative stress-dependent and independent effects of amyloid beta protein are detected by 3-(4,5-dimethylthiazol-2-y1)-2, 5-diphenyltetrazolium bromide (MTT) reduction assay
32. Enhancement of MTT, a tetrazolium salt, exocytosis by amyloid beta-protein and chloroquine in cultured rat astrocytes
33. Neuroprotective activity of acetyl-L-carnitine: Studies in vitro
34. Acetyl-L-carnitine arginine amide prevents beta 25-35-induced neurotoxicity in cerebellar granule cells
35. Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease
36. Beta-amyloid fragment 25-35 selectively decreases complex IV activity in isolated mitochondria
37. Suppression of mitochondrial succinate dehydrogenase, a primary target of beta-amyloid, and its derivative racemized at Ser residue
38. Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage
39. The effect of L-carnitine on the AZT-induced destruction of human myotubes. Part II: Treatment with L-carnitine improves the AZT-induced changes and prevents further destruction
40. Cerebrospinal fluid carnitine levels in patients with Alzheimer's disease
41. Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons
42. D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease
43. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction
44. Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity
45. Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: Protection by antioxidants
46. Vitamin E as an antioxidant/free radical scavenger against amyloid beta-peptide-induced oxidative stress in neocortical synaptosomal membranes and hippocampal neurons in culture: Insights into Alzheimer's disease
47. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid
48. Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons
49. Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways
50. Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons
51. Hydrogen peroxide mediates amyloid beta protein toxicity
52. Structural, metabolic and ionic requirements for the uptake of L-carnitine by primary rat cortical cells
53. Selective inhibition of Abeta fibril formation
54. Interaction of amyloid beta-protein with anionic phospholipids: Possible involvement of Lys28 and C-terminus aliphatic amino acids
55. Displacement currents associated with the insertion of alzheimer disease amyloid beta-peptide into planar bilayer membranes
56. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition
57. Sites of action of camitine and its derivatives on the cardiovascular system. Interactions with membranes
58. Acetyl-L-carnitine influences the fluidity of brain microsomes and of liposomes made of rat brain microsomal lipid extracts
59. Amyloid beta-peptides increase annular and bulk fluidity and induce lipid peroxidation in brain synaptic plasma membranes
60. Effects of beta-amyloid peptides on the fluidity of membranes from frontal and parietal lobes of human brain. High potencies of A beta 1-42 and A beta 1-43