Insulin increases the potency of glycine at ionotropic glycine receptors

Molecular Pharmacology

Volumn 71, Issue 5, 2007, Pages 1277-1287

  Caraiscos, Valerie B ^a   Bonin, Robert P ^a   Newell, J Glen ^d   Czerwinska, Elzbieta ^a   Macdonald, John F ^a   Orser, Beverley A ^a,b,c  

^a SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE; GLYCINE RECEPTOR; HYDROXY 2 NAPHTHALENYLMETHYLPHOSPHONIC ACID TRISACETOXYMETHYL ESTER; INSULIN; INSULIN RECEPTOR; LAVENDUSTIN A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; DRUG MECHANISM; EVOKED RESPONSE; HUMAN; HUMAN CELL; PATCH CLAMP; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; SPINAL CORD NERVE CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; DRUG SYNERGISM; GLYCINE; GRAMICIDIN; HUMANS; INSULIN; MICE; NEURONS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PROTEIN-TYROSINE KINASES; RECEPTOR, INSULIN; RECEPTORS, GLYCINE; SPINAL CORD; SYNAPTIC TRANSMISSION; ZINC;

EID: 34247473420     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.033563     Document Type: Article

References (39)

1. Aguayo LG, van Zundert B, Tapia JC, Carrasco MA, and Alvarez FJ (2004) Changes on the properties of glycine receptors during neuronal development. Brain Res Brain Res Rev 47:33-45.
2. Akaike N (1996) Gramicidin perforated patch recording and intracellular chloride activity in excitable cells. Prog Biophys Mol Biol 65:251-264.
3. Ataka T and Gu JG (2006) Relationship between tonic inhibitory currents and phasic inhibitory activity in the spinal cord lamina II region of adult mice. Mol Pain 2:36.
4. Beyer C, Banas C, Gomora P, and Komisaruk BR (1988) Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. Pharmacol Biochem Behav 29:73-78.
5. Beyer C, Roberts LA, and Komisaruk BR (1985) Hyperalgesia induced by altered glycinergic activity at the spinal cord. Life Sci 37:875-882.
6. Caraiscos VB, Mihic SJ, MacDonald JF, and Orser BA (2002) Tyrosine kinases enhance the function of glycine receptors in rat hippocampal neurons and human alpha1beta glycine receptors. J Physiol 539:495-502.
7. Clarke DW, Mudd L, Boyd FT Jr, Fields M, and Raizada MK (1986) Insulin is released from rat brain neuronal cells in culture. J Neurochem 47:831-836.
8. Courteix C, Bardin M, Massol J, Fialip J, Lavarenne J, and Eschalier A (1996) Daily insulin treatment relieves long-term hyperalgesia in streptozocin diabetic rats. Neuroreport 7:1922-1924.
9. De Meyts P, Palsgaard J, Sajid W, Theede AM, and Aladdin H (2004) Structural biology of insulin and IGF-1 receptors. Novartis Found Symp 262:160-171.
10. Ferguson SS (2003) Receptor tyrosine kinase transactivation: fine-tuning synaptic transmission. Trends Neurosci 26:119-122.
11. Havrankova J, Schmechel D, Roth J, and Brownstein M (1978) Identification of insulin in rat brain. Proc Natl Acad Sci USA 75:5737-5741.
12. 2+- as an essential endogenous modulator of glycinergic neurotransmission. Neuron 52:679-690.
13. Jones ML and Leonard JP (2005) PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits. J Neurochem 92:1431-1438.
14. i2 in human intestinal smooth muscle: Gβγ-dependent mitogen-activated protein kinase activation and growth. J Biol Chem 276:7187-7194.
15. Laube B, Kuhse J, Rundstrom N, Kirsch J, Schmieden V, and Betz H (1995) Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors. J Physiol 483:613-619.
16. Laube B, Maksay G, Schemm R, and Betz H (2002) Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol Sci 23:519-527.
17. Legendre P (2001) The glycinergic inhibitory synapse. Cell Mol Life Sci 58:760-793.
18. - concentrations depress G-protein-modulated ionic conductances. J Neurosci 17:6133-6141.
19. Lynch JW (2004) Molecular structure and function of the glycine receptor chloride channel. Physiol Rev 84:1051-1095.
20. A receptor currents is gated by insulin signaling in the prefrontal cortex. J Neurosci 23:1159-1168.
21. Park CR (2001) Cognitive effects of insulin in the central nervous system. Neurosci Biobehav Rev 25:311-323.
22. Pribilla I, Takagi T, Langosch D, Bormann J, and Betz H (1992) The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels. EMBO (Eur Mol Biol Organ) J 11:4305-4311.
23. Reichardt LF (2006) Neurotrophin-regulated signalling pathways. Philos Trans R Soc Lond B Biol Sci 361:1545-1564.
24. Saltiel AR and Pessin JE (2002) Insulin signaling pathways in time and space. Trends Cell Biol 12:65-71.
25. Saperstein R, Vicario PP, Strout HV, Brady E, Slater EE, Greenlee WJ, Ondeyka DL, Patchett AA, and Hangauer DG (1989) Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells. Biochemistry 28:5694-5701.
26. Schulingkamp RJ, Pagano TC, Hung D, and Raffa RB (2000) Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci Biobehav Rev 24:855-872.
27. Simpson RK Jr, Gondo M, Robertson CS, and Goodman JC (1996) Reduction in the mechanonociceptive response by intrathecal administration of glycine and related compounds. Neurochem Res 21:1221-1226.
28. Simpson RK Jr and Huang W (1998) Glycine receptor reduction within segmental gray matter in a rat model in neuropathic pain. Neurol Res 20:161-168.
29. Skeberdis VA, Lan J, Zheng X, Zukin RS, and Bennett MV (2001) Insulin promotes rapid delivery of N-methyl-D-aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci USA 98:3561-3566.
30. Sorkin LS and Puig S (1996) Neuronal model of tactile allodynia produced by spinal strychnine: effects of excitatory amino acid receptor antagonists and a mu-opiate receptor agonist. Pain 68:283-292.
31. Ster J, Colomer C, Monzo C, Duvoid-Guillou A, Moos F, Alonso G, and Hussy N (2005) Insulin-like growth factor-1 inhibits adult supraoptic neurons via complementary modulation of mechanoreceptors and glycine receptors. J Neurosci 25:2267-2276.
32. Sugimoto K, Murakawa Y, and Sima AA (2002) Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord. J Peripher Nerv Syst 7:44-53.
33. Takeshita N and Yamaguchi I (1997) Insulin attenuates formalin-induced nociceptive response in mice through a mechanism that is deranged by diabetes mellitus. J Pharmacol Exp Ther 281:315-321.
34. Taniguchi CM, Emanuelli B, and Kahn CR (2006) Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol 7:85-96.
35. A receptors to postsynaptic domains by insulin. Nature (Lond) 388:686-690.
36. Xing Y, Sonner J, Laster MJ, Abaigar W, Caraiscos VB, Orser B, and Eger EI (2004) Insulin decreases isoflurane minimum alveolar anesthetic concentration in rats independently of an effect on the spinal cord. Anesth Analg 98:1712-1717.
37. Yaksh TL (1989) Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain 37:111-123.
38. Yevenes GE, Moraga-Cid G, Guzman L, Haeger S, Oliveira L, Olate J, Schmalzing G, and Aguayo LG (2006) Molecular determinants for G protein βγ modulation of ionotropic glycine receptors. J Biol Chem 281:39300-39307.
39. Yevenes GE, Peoples RW, Tapia JC, Parodi J, Soto X, Olate J, and Aguayo LG (2003) Modulation of glycine-activated ion channel function by G-protein βγ subunits. Nat Neurosci 6:819-824.