Response kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA ρ- and γ2-subunits

Proceedings of the Royal Society B: Biological Sciences

Volumn 266, Issue 1436, 1999, Pages 2419-2425

  Qian, Haohua ^a   Ripps, Harris ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Bipolar cells; GABA(C) receptors; Retina; Xenopus oocytes; subunits

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID C RECEPTOR; BICUCULLINE; CHLORIDE CHANNEL; DIAZEPAM; PICROTOXIN; RECEPTOR SUBUNIT; ZINC;

ANIMAL CELL; ARTICLE; EMBRYO; NERVE CELL; NONHUMAN; OOCYTE; PERCH; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; RETINA; XENOPUS;

ANIMALIA;

EID: 0033534018     PISSN: 09628452     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rspb.1999.0941     Document Type: Article

References (44)

1. Albrecht, B. E., Breitenbach, U., Stuhmer, T., Harvey, R. J. & Darlison, M. G. 1997 In situ hybridization and reverse transcription polymerase chain reaction studies on the expression of the GABA(C) receptor rho1- and rho2-subunit genes in avian and rat brain. Eur. J. Neurosci. 9, 2414-2422.
2. Barnard, E. A., Skolnick, P., Olsen, R.W., Mohler, H., Sieghart, W., Biggio, O., Braestrup, C., Bateson, A. N. & Langer, S. Z. 1998 International Union of Pharmacology, XV. Subtypes γ-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50, 291-313.
3. C receptors. Trends Neurosci. 18, 515-519.
4. Boue-Grabot, E., Roudbaraki, M., Bascles, L., Tramu, G., Bloch, B. & Garret, M. 1998 Expression of GABA receptor rho subunits in rat brain. J. Neurochem. 70, 899-907.
5. Cutting, G. R. (and 11 others) 1991 Cloning of the γ-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina, Proc. Natl Acad. Sci. USA 88, 2673-2677.
6. Cutting, G. R., Curristin, S., Zoghbi, H., O'Hara, B., Selden, M. F. & Uhl, G. R. 1992 Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. Genomics 12, 801-806.
7. 2+. Neuron 5, 781-788.
8. C receptor rho subunits are heterogeneously expressed in the human CNS and form homo- and heterooligomers with distinct physical properties. Eur. J. Neurosci. 11, 41-50.
9. Enz, R., Brandsẗtter, J. H., Hartveit, E., Wässle, H. & Bormann, J. 1995 Expression of GABA receptor rho 1 and rho 2 subunits in the retina and brain of the rat. Eur. J. Neurosci. 7, 1495-1501.
10. C, receptor rho subunits in the mammalian retina. J. Neurosci. 16, 4179-4490.
11. - channels in rat retinal bipolar cells. Nature 361, 159-163.
12. Grant, G. B. & Werblin, F. S. 1994 Low-cost data acquisition and analysis programs for electrophysiology, J. Neurosci. Meth. 55, 89-98.
13. A receptors in the rabbit retina. Cell Tissue Res. 276, 295-307.
14. A receptor subunits have differential distributions in the rat retina: in situ hybridization and immunohistochemistry. J. Comp. Neurol. 353, 553-571.
15. A receptor currents in mouse fibroblasts. J. Physiol. 514, 27-45.
16. Hackam, A. S., Wang, T. L., Guggino, W. B. & Cutting, G. R. 1998 Sequences in the amino termini of GABA rho and GABA(A) subunits specify their selective interaction in vitro. J. Neurochem. 70, 40-46.
17. Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. 1981 Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391, 85-100.
18. Johnston, G. A. R. 1986 Multiplicity of GABA receptors. In Receptor biochemistry and methodology, vol. 5 (ed. R. W. Olsen & J. C. Venter), pp. 57-71. New York: Alan R. Liss, Inc.
19. Johnston, G. A. R. 1996 GABAc receptors: relatively simple transmitter-gated ion channels? Trends Pharmacol. Sci, 17, 319-323.
20. Koulen, P., Brandstätter, J. H., Kröger, S., Enz, R., Bormann, J. & Wässle, H. 1997 Immunocytochemical localization of the GABA(C) receptor rho subunits in the cat, goldfish, and chicken retina. J. Comp. Neurol. 380, 520-532.
21. Koulen, P., Brandstätter, J. H., Enz., R., Bormann, J. & Wässle, H. 1998 Synaptic clustering of GABA(C) receptor rho-subunits in the rat retina. Eur. J. Neurosci. 10, 115-127.
22. Krampfl, K., Lepier, A., Jahn, K., Franke, C. & Bufler, J. 1998 Molecular modulation of recombinant rat alphalbeta2-gamma2 GABA(A) receptor channels by diazepam. Neurosci. Lett. 256, 113-146.
23. Macdonald, R. L., Rogers, C. J. & Twyman, R. K. 1989 Barbiturate regulation of kinetic properties of the GABAA receptor channel of mouse spinal neurones in culture. J. Physiol. 417, 483-500.
24. McKernan, R. M. & Whiting. P. J. 1996 Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci. 19, 139-143.
25. Porter, N. M., Angelotti, T. P., Twyman, R. E. & Macdonald, R. L. 1992 Kinetic properties of alpha 1 beta 1 gamma-aminobutyric acidA receptor channels expressed in Chinese hamster ovary cells: regulation by pentobarbital and picrotoxin. Mol. Pharmacol. 42, 872-881.
26. A receptor subunit for benzodiazepine pharmacology. Nature 338, 582-585.
27. Qian, H. & Dowling, J. E. 1993 Novel GABA responses from rod-driven retinal horizontal cells. Nature 361, 162-164.
28. C receptors on hybrid bass retinal bipolar cells. J. Neurophysiol. 74, 1920-1928.
29. C and rho subunit receptors from the white perch retina. Vis. Neurosci. 14, 843-851.
30. Qian, H., Li, L., Chappell, R. L. & Ripps, H. 1997b GABA receptors of bipolar cells from the skate retina: actions of zinc on GABA-mediated membrane currents. J. Neurophysiol. 78, 2402-2412.
31. Qian, H., Dowling, J. E. & Ripps, H. 1998 Molecular and pharmacological properties of GABA-rho subunits from white perch retina. J. Neurobiol. 37, 305-320.
32. Rae, J., Cooper, K., Gates, R & Watshy, M. 1991 Low access resistance perforated patch recordings using amphotericin B. J. Neurosci. Meth. 37, 15-26.
33. Sanna, E., Garau, F. & Harris, R. A. 1995 Novel properties of homomeric beta 1 gamma-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital. Mol. Pharmacol. 47, 213-217.
34. A receptor subunits: role of the delta subunit. J. Neurosci. 14, 7077-7086.
35. Seeburg, P. H., Wisden, W., Verdoorn, T. A., Pritchett, D. B., Werner, P., Herb, A., Luddens, H., Sprengel, R. & Sakmann, B. 1990 The GABAA receptor family: molecular and functional diversity. Cold Spring Harb. Symp. Quant. Biol. 55, 29-40.
36. Shimada, S., Cutting, G. & Uhl, G. R. 1992 γ-aminobutyric acid A or C receptor? γ-aminobutyric acid rho 1 receptor RNA induces bicuculline-, barbiturate-, and benzodiazepine-insensitive γ-aminobutyric acid responses in Xenopus oocytes. Mol. Pharmacol. 41, 683-687.
37. Sigel, E., Baur, R., Trube, G., Möhler, H. & Malherbe, P. 1990 The effect of subunit composition of rat brain GABAA receptors on channel function. Neuron 5, 703-711.
38. Sivilotti, L. & Nistri, A. 1991 GABA receptor mechanisms in the central nervous system. Prog. Neurobiol. 36, 35-92.
39. Study, R. E. & Barker, J. L. 1981 Diazepam and (-)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of γ-aminobutyric acid responses in cultured central neurons. Proc. Natl Acad. Sci. USA 78, 7180-7184.
40. Wang,T.-L., Hackam, A. S., Guggino,VV. R. & Cutting, G. R. 1994 A novel γ-aminobutyric acid receptor subunit (rho 2) cloned from human retina forms bicuculline-insensitive homooligomeric receptors in Xenopus oocytes. J. Neurosci. 14, 6524-6531.
41. Wässle, H., Koulen, P., Brändstatter, J. H., Fletcher, E. L. & Becker, C. M. 1998 Glycine and GABA receptors in the mammalian retina, Vision Res. 38, 1411-1430.
42. Wegelius, K., Pasternack, M., Hiltunen, J. O., Rivera, C., Kaila, K., Saarma, M. & Reeben, M. 1998 Distribution of GABA receptor rho subunit transcripts in the rat brain. Eur. J. Neurosci. 10, 350-357.
43. A receptor rho 1 subunit expression in single rat retinal bipolar cells. Vis. Neurosci. 13, 283-292.
44. Zhang, D., Pan, Z. II., Zhang, X., Brideau, A. D. & Lipton, S. A. 1995 Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. Natl Acad. Sci. USA 92, 11756-11760.