In vitro diffusion of the immunosuppressant tacrolimus through human and rabbit corneas

Journal of Ocular Pharmacology and Therapeutics

Volumn 23, Issue 2, 2007, Pages 146-151

  Van Eyk, Armorél D ^a   Van Der Bijl, Pieter ^a   Meyer, David ^a  

^a UNIVERSITY OF STELLENBOSCH   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

TACROLIMUS; TRITIUM;

ANIMAL TISSUE; ARTICLE; CORNEA PERMEABILITY; DRUG DIFFUSION; DRUG PENETRATION; EVALUATION; HUMAN; HUMAN TISSUE; KINETICS; NONHUMAN; RABBIT; STEADY STATE; TISSUE CULTURE;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CORNEA; DIFFUSION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; MODELS, ANIMAL; OPHTHALMIC SOLUTIONS; PERMEABILITY; RABBITS; SPECIES SPECIFICITY; TACROLIMUS;

EID: 34247393145     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.2006.0105     Document Type: Article

References (35)

1. Yoshida, H., Tamura, S., Toyoda, T., et al. In vitro release of tacrolimus from tacrolimus ointment and its speculated mechanism. Int. J. Pharm. 270:55-64, 2004.
2. Maes, B.D., and Vanrenterghem, Y.F.Ch. Cyclosporine: Advantages versus disadvantages vis-à-vis tacrolimus. Transpl. Proc. 36(Suppl. 2S):40S-49S, 2004.
3. Martins, L., Ventura, A., Branco, A., et al. Cyclosporine versus tacrolimus in kidney transplantation: Are there differences in nephrotoxicity? Transpl. Proc. 36:877-879, 2004.
4. Abou-Jaoude, M.M., Najm, R., Shaheen, J., et al. Tacrolimus (FK506) versus cyclosporine microemulsion (Neoral) as maintenance immunosuppression therapy in kidney transplant recipients. Transpl. Proc. 37:3025-3028, 2005.
5. Warnecke, G., Avsar, M., Steinkamp, T., et al. Tacrolimus versus cyclosporine induction therapy in pulmonary transplantation in miniature swine. Eur. J. Cardiothorac. Surg. 28:454-460, 2005.
6. González-Pinto, I.M., Rimola, A., Margarit, C., et al. Five-year follow-up of a trial comparing tacrolimus and cyclosporine microemulsion in liver transplantation. Transpl. Proc. 37:1713-1715, 2005.
7. Malaise, J., Saudek, F., Bouček, P., et al. Tacrolimus compared with cyclosporine microemulsion in primary simultaneous pancreas-kidney transplantation: the EURO-SPK 3-year results. Transpl. Proc. 37:2843-2845, 2005.
8. Nghiem, P., Pearson, G., and Langley, R.G. Tacrolimus and pimecrolimus: From clever prokaryotes to inhibiting calcineurin and treating atopic dermatitis. J. Am. Acad. Dermatol. 46:228-241, 2002.
9. Joseph, M.A., Kaufman, H.E., and Insler, M. Topical tacrolimus ointment for treatment of refractory anterior segment inflammatory disorders. Cornea 24(4):417-420, 2005.
10. Beck, L.A. The efficacy and safety of tacrolimus ointment: A clinical review. J. Am. Acad. Dermatol. 53:S165-S170, 2005.
11. Reinhard, T., Reis, A., Mayweg, S., et al. Topical FK506 in inflammatory corneal and conjunctival diseases: A pilot study. Klin. Monatsbl. Augenheilkd 219(3):125-131, 2002.
12. Bertelmann, E., and Pleyer, U. Immunomodulatory therapy in ophthalmology - is there a place for topical application? Ophthalmologica 218(6):359-367, 2004.
13. Rozycki, T.W., Rogers, III, R.S., Pittelkow, M.R., et al. Topical tacrolimus in the treatment of symptomatic oral lichen planus: A series of 13 patients. J. Am. Acad. Dermatol. 46:27-34, 2002.
14. Brooks, D.E. Current concepts in veterinary ophthalmology. 2003. Online document at: www.sacs.vetmed.ufl.edu/ophtho/Basic_Ophtho/Basic_Ophtho.htm / Accessed: January 30, 2006.
15. Krämer, B.K., Krüger, B., Mack, M., et al. Steroid withdrawal or steroid avoidance in renal transplant recipients: Focus on tacrolimus-based immunosuppressive regimens. Transpl. Proc. 37:1789-1791, 2005.
16. Del Tacca, M. Prospects for personalized immunosuppression: Pharmacologic tools - a review. Transpl. Proc. 36:687-689, 2004.
17. Hooks, M.A. Tacrolimus, a new immunosuppressant - a review of the literature. Ann. Pharmacother. 28(4):501-511, 1994.
18. Reis, A., Reinhard, T., Sundmacher, R., et al. A comparative investigation of FK506 and cyclosporine A in murine corneal transplantation. Graefe's Arch. Clin. Exp. Ophthalmol. 236:785-789, 1998.
19. Sloper, C.M.L., Powell, R.J., and Dua, H.S. Tacrolimus (FK506) in the management of high-risk corneal and limbal grafts. Ophthalmology 108(10):1838-1844, 2001.
20. Jabs, D.A., Rosenbaum, J.T., Foster, C.S., et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: Recommendations of an expert panel. Am. J. Ophthalmol. 130:492-513, 2000.
21. Scott, L.J., McKeage, K., Keam, S.J., et al. Tacrolimus: A further update of its use in the management of organ transplantation. Drugs 63(12):1247-1297, 2003.
22. Pras, E., Neumann, R., Zandman-Goddard, G., et al. Intraocular inflammation in autoimmune diseases. Semin. Arthr. Rheum. 34:602-609, 2004.
23. Järvinen, K., Järvinen, T., and Urtti A. Ocular absorption following topical delivery. Adv. Drug. Deliv. Rev. 16:3-19, 1995.
24. Toropainen, E., Ranta, V.-P., Vellonen, K.-S., et al. Paracellular and passive transcellular permeability in immortalized human corneal epithelial cell culture model. Eur. J. Pharm. Sci. 20:99-106, 2003.
25. Reichl, S., Döhring, S., Bednarz, J., et al. Human cornea construct HCC - an alternative for in vitro permeation studies? A comparison with human donor corneas. Eur. J. Pharm. Biopharm. 60:305-308, 2005.
26. Le Bourlais, C., Acar, L., Zia, H., et al. Ophthalmic drug delivery systems - recent advances. Prog. Retin. Eye Res. 17(1):33-58, 1998.
27. Van der Bijl, P., Engelbrecht, A.H., Van Eyk, A.D., et al. Comparative permeability of human and rabbit corneas to cyclosporine and tritiated water. J. Ocul. Pharmacol. Ther. 18(5):419-427, 2002.
28. Van der Bijl, P., Van Eyk, A.D., Seifart, H.I., et al. Diffusion of metronidazole released from aqueous solution and a gel through human and rabbit corneas. J. Ocul. Pharmacol. Ther. 20(5):421-429, 2004.
29. Van der Bijl, P., Van Eyk, A.D., Seifart, H.I., et al. In vitro transcorneal penetration of metronidazole and its potential use as adjunct therapy in Acanthamoeba keratitis. Cornea 23(4):386-389, 2004.
30. Van der Bijl, P., Van Eyk, A.D., and Meyer D. Effects of three penetration enhancers on transcorneal permeation of cyclosporine. Cornea 20(5):505-508, 2001.
31. Motulsky, H. Intuitive biostatistics. In: Graphpad Software. New York: Oxford University Press, 1995.
32. Zhang, W., Prausnitz, M.R., and Edwards, A. Model of transient drug diffusion across cornea. J. Contr. Rel. 99:241-258, 2004.
33. Fu, X.C., and Liang, W.Q. A simple model for the prediction of corneal permeability. Int. J. Pharm. 232:193-197, 2002.
34. Stephen, R., Kaufman, M.D. Problems with the Draize Test[Website]. 2006. Online document at: www.curedisease.com/Perspectives/vol_1_1989/Problems% 20with%20the%20Draize. html / Accessed: November 20, 2006.
35. Lauerma, A.I, Surber, C., and Maibach, H.I. Absorption of topical tacrolimus (FK506) in vitro through human skin: Comparison with cyclosporin A. Skin Pharmacol. 10(5-6):230-234, 1997.