A simple model for the prediction of corneal permeability

International Journal of Pharmaceutics

Volumn 232, Issue 1-2, 2002, Pages 193-197

  Fu, Xuchun C ^a   Liang, Wenquan Q ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Corneal permeability; Molecular volume; Net atomic charges; Prediction model

Indexed keywords

ACEBUTOLOL; AMIDE; ATENOLOL; BEVANTOLOL; BUFURALOL; BUTANOL; CLONIDINE; CORTODOXONE; DEOXYCORTICOSTERONE; DEXAMETHASONE; DEXAMETHASONE ACETATE; FLUOROMETHOLONE; HYDROCORTISONE; IBUPROFEN; LEVOBUNOLOL; METHANOL; METOPROLOL; NADOLOL; OXPRENOLOL; PENBUTOLOL; PHENYLEPHRINE; PREDNISOLONE; PREDNISOLONE ACETATE; PROGESTERONE; PROPRANOLOL; SOTALOL; TESTOSTERONE; TIMOLOL; TRIAMCINOLONE ACETATE; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; ATOMIC PARTICLE; CALCULATION; CONTROLLED STUDY; CORNEA PERMEABILITY; MODEL; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTUM CHEMISTRY; RABBIT;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; CORNEA; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACOKINETICS; PREDICTIVE VALUE OF TESTS; RABBITS;

EID: 0037203658     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00902-4     Document Type: Article

References (15)

1. Algorithms for skin permeability using hydrogen bond descriptors: The problem of steroids
2. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 1. Prediction of intestinal absorption
3. A new general purpose quantum mechanical molecular model
4. A modified mathematical model for percutaneous absorption of drugs
5. Correlation of drug absorption with molecular charge distribution
6. Mechanisms of corneal drug penetration: In vivo and in vitro kinetics
7. Ex vivo permeation study of indomethacin from a submicron emulsion through albino rabbit cornea
8. Theoretical calculation and prediction of brain-blood partitioning of organic solutes using Molsurf parameterization and PLS statistics
9. Predicting skin permeability
10. Relationship between steroid permeability across excised rabbit cornea and octanol-water partition coefficients
11. Corneal penetration behavior of beta-blocking agents I: Physicochemical factors
12. The control of drug bioavailability from ophthalmic dosage forms
13. Estimation of Caco-2 cell permeability using calculated molecular descriptors
14. Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: A comparison with corneal penetration
15. Unified model for the corneal permeability of related and diverse compounds with respect to their physicochemical properties