Proteochemometric modeling reveals the interaction site for Trp9 modified α-MSH peptides in melanocortin receptors

Proteins: Structure, Function and Genetics

Volumn 67, Issue 3, 2007, Pages 653-660

  Lapinsh, Maris ^a   Prusis, Peteris ^a   Petrovska, Ramona ^a   Uhlén, Staffan ^a   Mutule, Ilze ^a   Veiksina, Santa ^a   Wikberg, Jarl E S ^a,b  

^a UPPSALA UNIVERSITY   (Sweden)

^b Pharmaceutical Pharmacology   (Sweden)

Author keywords

Experimental design; G protein coupled receptors; Melanocortin receptors; Multipart chimeric receptors; Peptide library; Proteochemometrics

Indexed keywords

ALPHA INTERMEDIN; AMINO ACID; ARGININE; ASPARTIC ACID; CHIMERIC PROTEIN; CYSTEINE; GLYCINE; INTERMEDIN DERIVATIVE; LEUCINE; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; MELANOCORTIN RECEPTOR; MUTANT PROTEIN; PEPTIDE LIBRARY; PROLINE; TRYPTOPHAN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BIOINFORMATICS; CHEMOMETRIC ANALYSIS; CONTROLLED STUDY; HUMAN; LIGAND BINDING; MATHEMATICAL MODEL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; RADIOASSAY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ALPHA-MSH; BINDING SITES; HUMANS; MODELS, MOLECULAR; PEPTIDES; PROTEIN BINDING; RECEPTORS, MELANOCORTIN; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

EID: 34247233088     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21323     Document Type: Article

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