Development of proteo-chemometrics: A novel technology for the analysis of drug-receptor interactions

Biochimica et Biophysica Acta - General Subjects

Volumn 1525, Issue 1-2, 2001, Pages 180-190

  Lapinsh, Maris ^a   Prusis, Peteris ^a   Gutcaits, Alexandrs ^a   Lundstedt, Torbjörn ^b   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Melacure Therapeutics AB   (Sweden)

Author keywords

Chimeric receptor; Ligand binding; Modeling; Partial least squares; Partial least squares projection to latent structure; Proteo chemometrics; Site directed mutagenesis

Indexed keywords

4 PIPERIDYLOXAZOLE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CHEMOMETRIC ANALYSIS; CORRELATION FUNCTION; DRUG DESIGN; DRUG RECEPTOR BINDING; HUMAN; LIGAND BINDING; METHODOLOGY; MODEL; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; TECHNOLOGY;

ADRENERGIC ALPHA-ANTAGONISTS; DRUG DESIGN; HUMANS; LIGANDS; MODELS, BIOLOGICAL; OXAZOLES; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY; POINT MUTATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DRUG; RECOMBINANT FUSION PROTEINS;

EID: 0035895752     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(00)00187-2     Document Type: Article

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