PLS modeling of chimeric MS04/MSH-peptide and MC1/MC3-receptor interactions reveals a novel method for the analysis of ligand-receptor interactions

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1544, Issue 1-2, 2001, Pages 350-357

  Prusis, Peteris ^a   Muceniece, Ruta ^a   Andersson, Per ^d   Post, Claes ^c   Lundstedt, Torbjörn ^b,c   Wikberg, Jarl E S ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c Melacure Therapeutics AB   (Sweden)

^d UMEÅ UNIVERSITY   (Sweden)

Author keywords

Chimeric melanocortin receptor; MSH peptide binding; PLS modeling

Indexed keywords

ALPHA INTERMEDIN; CHIMERIC PROTEIN; MELANOCORTIN RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHIMERA; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; RECEPTOR BINDING; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; LIGANDS; MELANOCYTE-STIMULATING HORMONES; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035847119     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(00)00249-1     Document Type: Article

References (11)

1. Phage display selection on whole cells yields a peptide specific for melanocortin receptor 1
2. 1 receptor
3. Melanocortin receptors: Perspectives for novel drugs
4. 1 receptor super-selective MS04/MS05 peptides
5. Partial least-squares regression: A tutorial
6. Principal component analysis
7. Experimental design and optimization
8. Chimeric melanocortin 1/3 receptors; Identification of domains determining the specificity of MSH peptides
9. Modeling of the three-dimensional structure of the human melanocortin-1 receptor using an automated method and docking of a rigid cyclic MSH core peptide