A high-throughput screening platform for inhibitors of the riboflavin biosynthesis pathway

Analytical Biochemistry

Volumn 365, Issue 1, 2007, Pages 52-61

  Kaiser, Johannes ^a   Illarionov, Boris ^a   Rohdich, Felix ^a   Eisenreich, Wolfgang ^a   Saller, Sabine ^a   den Brulle, Jan Van ^b   Cushman, Mark ^c   Bacher, Adelbert ^a,d   Fischer, Markus ^d,e  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Sloning BioTechnology GmbH   (Germany)

^c PURDUE UNIVERSITY   (United States)

^d Ikosatec GmbH   (Germany)

^e UNIVERSITY OF HAMBURG   (Germany)

Author keywords

3,4 Dihydroxy 2 butanone 4 phosphate synthase; 6,7 Dimethyl 8 ribityllumazine synthase; High throughput screening for inhibitors; Riboflavin biosynthesis; Riboflavin synthase; Targets for novel antiinfective drugs

Indexed keywords

BIOCHEMISTRY;

13C NMR; BIOSYNTHETIC PATHWAY; HIGH THROUGHPUT SCREENING; POTENTIAL TARGETS; RIBOFLAVIN BIOSYNTHESIS; SYNTHASE INHIBITOR; SYNTHASES;

BIOSYNTHESIS;

3,4 DIHYDROXY 2 BUTANONE 4 PHOSPHATE SYNTHASE; 6,7 DIMETHYL 8 RIBITYLLUMAZINE SYNTHASE; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; ENZYME INHIBITOR; FUNGAL ENZYME; RESTRICTION ENDONUCLEASE; RIBOFLAVIN; RIBOFLAVIN SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CANDIDA GLABRATA; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DETERMINATION; DRUG TARGETING; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; MAGNAPORTHE GRISEA; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOTOMETRY; PLASMID; PRIORITY JOURNAL;

EID: 34247196744     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2007.02.033     Document Type: Article

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