Crystal structure of an archaeal pentameric riboflavin synthase in complex with a substrate analog inhibitor: Stereochemical implications

Journal of Biological Chemistry

Volumn 281, Issue 2, 2006, Pages 1224-1232

  Ramsperger, Arne ^a   Augustin, Martin ^a,d   Schott, Ann Kathrin ^b,e   Gerhardt, Stefan ^a,e   Krojer, Tobias ^a,f   Eisenreich, Wolfgang ^b   Illarionov, Boris ^b   Cushman, Mark ^c   Bacher, Adelbert ^b   Huber, Robert ^a   Fischer, Markus ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c PURDUE UNIVERSITY   (United States)

^d PROTEROS BIOSTRUCTURES GMBH   (Germany)

^e ASTRAZENECA   (United Kingdom)

^f RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; COMPLEXATION; CRYSTAL STRUCTURE; ENZYME INHIBITION; TOPOLOGY;

ANALOG INHIBITOR; ARCHAEAL PENTAMERIC RIBOFLAVIN SYNTHASE; HOMOTRIMERS;

ENZYME KINETICS;

6,7 DIOXO 8 RIBITYLLUMAZINE; ARCHAEAL PROTEIN; LUMAZINE; MONOMER; RIBOFLAVIN SYNTHASE; UNCLASSIFIED DRUG; 6,7 DIMETHYL 8 RIBITYLLUMAZINE SYNTHASE; 6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE; 6,7-DIOXO-8-RIBITYLLUMAZINE; DRUG DERIVATIVE; MULTIENZYME COMPLEX; PTERIDINE DERIVATIVE; RIBITOL; RIBOFLAVIN; RIBOSE;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STEREOCHEMISTRY; X RAY ANALYSIS; ARCHAEBACTERIUM; BINDING SITE; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; ENZYMOLOGY; METABOLISM; METHANOBACTERIUM; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE HOMOLOGY; STEREOISOMERISM; X RAY CRYSTALLOGRAPHY;

ARCHAEA; BACTERIA (MICROORGANISMS); EUKARYOTA; METHANOCALDOCOCCUS JANNASCHII; METHANOTHERMOBACTER;

AMINO ACID SEQUENCE; ARCHAEA; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; KINETICS; METHANOBACTERIACEAE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PTERIDINES; RIBITOL; RIBOFLAVIN; RIBOFLAVIN SYNTHASE; RIBOSE; SEQUENCE HOMOLOGY, AMINO ACID; STEREOISOMERISM;

EID: 33644864128     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M509440200     Document Type: Article

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