Dendritic cells from lupus-prone mice are defective in repressing immunoglobulin secretion

Journal of Immunology

Volumn 178, Issue 8, 2007, Pages 4803-4810

  Gilbert, Mileka M ^a   Carnathan, Diane G ^a   Cogswell, Patricia C ^a   Lin, Li ^b   Baldwin Jr , Albert S ^a   Vilen, Barbara J ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b IL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; DNA; I KAPPA B ALPHA; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DISEASE PREDISPOSITION; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL TOLERANCE; LUPUS VULGARIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 34247162827     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.8.4803     Document Type: Article

References (62)

1. Mok, C. C., and C. S. Lau. 2003. Pathogenesis of systemic lupus erythematosus. J. Clin. Pathol. 56: 481-490.
2. + T cells from lupus-prone mice are hyperresponsive to T cell receptor engagement with low and high affinity peptide antigens: a model to explain spontaneous T cell activation in lupus. J. Exp. Med. 193: 329-337.
3. + regulatory T cells in vitro: a novel defect of T cell regulation in systemic lupus erythematosus. Arthritis Rheum. 52: 1180-1184.
4. Liossis, S. N., X. Z. Ding, G. J. Dennis, and G. C. Tsokos. 1998. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J. Clin. Invest. 101: 1448-1457.
5. Brundula, V., L. J. Rivas, A. M. Blasini, M. Paris, S. Salazar, I. L. Stekman, and M. A. Rodriguez. 1999. Diminished levels of T cell receptor ζ chains in peripheral blood T lymphocytes from patients with systemic lupus erythematosus. Arthritis Rheum. 42: 1908-1916.
6. Nambiar, M. P., E. J. Enyedy, V. G. Warke, S. Krishnan, G. Dennis, H. K. Wong, G. M. Kammer, and G. C. Tsokos. 2001. T cell signaling abnormalities in systemic lupus erythematosus are associated with increased mutations/ polymorphisms and splice variants of T cell receptor ζ chain messenger RNA. Arthritis Rheum. 44: 1336-1350.
7. + T cells from lupus-prone mice avoid antigen-specific tolerance induction in vivo. J. Immunol. 170: 741-748.
8. Yi, Y., M. McNerney, and S. K. Datta. 2000. Regulatory defects in Cb1 and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells. J. Immunol. 165: 6627-6634.
9. 1 lupus-prone mice. J. Immunol. 159: 5610-5619.
10. Koh, J. S., Z. Wang, and J. S. Levine. 2000. Cytokine dysregulation induced by apoptotic cells is a shared characteristic of murine lupus. J. Immunol. 165: 4190-4201.
11. Scott, R. S., E. J. McMahon, S. M. Pop, E. A. Reap, R. Caricchio, P. L. Cohen, H. S. Earp, and G. K. Matsushima. 2001. Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411: 207-211.
12. Manderson, A. P., M. Botto, and M. J. Walport. 2004. The role of complement in the development of systemic lupus erythematosus. Annu. Rev. Immunol. 22: 431-456.
13. Boackle, S. A., V. M. Holers, X. Chen, G. Szakonyi, D. R. Karp, E. K. Wakeland, and L. Morel. 2001. Cr2, a candidate gene in the murine Sle1c lupus susceptibility locus, encodes a dysfunctional protein. Immunity 15: 775-785.
14. Lipsky, P. E. 2001. Systemic lupus erythematosus: an autoimmune disease of B cell hyperactivity. Nat. Immunol. 2: 764-766.
15. Erikson, J., M. Z. Radic, S. A. Camper, R. R. Hardy, C. Carmack, and M. Weigert. 1991. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature 349: 331-334.
16. Goodnow, C. C., J. Crosbie, H. Jorgensen, R. A. Brink, and A. Basten. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature 342: 385-391.
17. Benschop, R. J., K. Aviszus, X. Zhang, T. Manser, J. C. Cambier, and L. J. Wysocki. 2001. Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. Immunity 14: 33-43.
18. Borrero, M., and S. H. Clarke. 2002. Low-affinity anti-Smith antigen B cells are regulated by anergy as opposed to developmental arrest or differentiation to B-1. J. Immunol. 168: 13-21.
19. Hulbert, C., B. Riseili, M. Rojas, and J. W. Thomas. 2001. B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J. Immunol. 167: 5535-5538.
20. Noorchashm, H., A. Bui, H. L. Li, A. Eaton, L, Mandik-Nayak, C. Sokol, K. M. Potts, E. Pure, and J. Erikson. 1999. Characterization of anergic anti-DNA B cells: B cell anergy is a T cell-independent and potentially reversible process. Int. Immunol. 11: 765-776.
21. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, et al. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334: 676-682.
22. Heltemes-Harris, L., X. Liu, and T. Manser. 2004. Progressive surface B cell antigen receptor down-regulation accompanies efficient development of antinuclear antigen B cells to mature, follicular phenotype. J. Immunol. 172: 823-833.
23. Cyster, J. G., S. B. Hartley, and C. C. Goodnow. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371: 389-395.
24. Mandik-Nayak, L., A. Bui, H. Noorchashm, A. Eaton, and J. Erikson. 1997. Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle. J. Exp. Med. 186: 1257-1267.
25. Kilmon, M. A., J. A. Rutan, S. H. Clarke, and B. J. Vilen. 2005. Cutting edge: low-affinity, smith antigen-specific B cells are tolerized by dendritic cells and macrophages. J. Immunol. 175: 37-41.
26. Balazs, M., F. Martin, T. Zhou, and J. Kearney. 2002. Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses. Immunity 17; 341-352.
27. Jego, G., A. K. Palucka, J. P. Blanck, C. Chalouni, V. Pascual, and J. Banchereau. 2003. Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6. Immunity 19: 225-234.
28. MacLennan, I., and C. Vinuesa. 2002. Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses. Immunity 17: 235-238.
29. Muraguchi, A., T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakajima, and T. Kishimoto. 1988. The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med. 167: 332-344.
30. Minges Wols, H. A., G. H. Underhill, G. S. Kansas, and P. L. Witte. 2002. The role of bone marrow-derived stromal cells in the maintenance of plasma cell longevity. J. Immunol. 169: 4213-4221.
31. Hirschfeld, M., Y. Ma, J. H. Weis, S. N. Vogel, and J. J. Weis. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 165: 618-622.
32. Haskill, S., A. A. Beg, S. M. Torhpkins, J. S. Morris, A. D. Yurochko, A. Sampson-Johannes, K. Mondal, P. Ralph, and A. S. Baldwin, Jr. 1991. Characterization of an immediate-early gene induced in adherent monocytes that encodes I κB-like activity. Cell 65: 1281-1289.
33. Karin, M. 1999. How NF-κB is activated: the role of the IκB kinase (IKK) complex. Oncogene 18: 6867-6874.
34. Yang, Y., C. T. Huang, X. Huang, and D. M. Pardoll. 2004. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nat. Immunol. 5: 508-515.
35. Wong, H. K., G. M. Kammer, G. Dennis, and G. C. Tsokos. 1999. Abnormal NF-κB activity in T lymphocytes from, patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expression. J. Immunol. 163: 1682-1689.
36. Liu, J., and D. Beller. 2002. Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-κB expression and binding to the IL-12 p40 promoter. J. Immunol. 169: 581-586.
37. Kobayashi, T., M. C. Walsh, and Y. Choi. 2004. The role of TRAF6 in signal transduction and the immune response. Microbes Infect. 6: 1333-1338.
38. Gallucci, S., M. Lolkema, and P. Matzinger. 1999. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5: 1249-1255.
39. Tackey, E., P. E. Lipsky, and G. G. Illei. 2004. Rationale for interleukin-6 blockade in systemic lupus erythematosus. Lupus 13: 339-343.
40. Richards, H. B., M. Satoh, M. Shaw, C. Libert, V. Poli, and W. H. Reeves. 1998. Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus. J. Exp. Med. 188: 985-990.
41. Linker-Israeli, M., R. J. Deans, D. J. Wallace, J. Prehn, T. Ozeri-Chen, and J. R. Klinenberg. 1991. Elevated levels of endogenous IL-6 in systemic lupus erythematosus: a putative role in pathogenesis. J. Immunol. 147: 117-123.
42. Grondal, G., I. Gunnarsson, J. Ronnelid, S. Rogberg, L. Klareskog, and I. Lundberg. 2000. Cytokine production, serum levels and disease activity in systemic lupus erythematosus. Clin. Exp. Rheumatol. 18: 565-570.
43. Peterson, E., A. D. Robertson, and W. Emlen. 1996. Serum and urinary interleukin-6 in systemic lupus erythematosus. Lupus 5: 571-575.
44. Davas, E. M., A. Tsirogianni, I. Kappou, D. Karamitsos, I. Economidou, and P. C. Dantis. 1999. Serum IL-6, TNFα, p55 srTNFα, p75srTNFα, srIL-2α levels and disease activity in systemic lupus erythematosus. Clin. Rheumatol. 18: 17-22.
45. + cells. Int. Immunol. 4: 1407-1412.
46. Suzuki, H., K. Yasukawa, T. Saito, M. Narazaki, A. Hasegawa, T. Taga, and T. Kishimoto. 1993. Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal. Eur. J. Immunol. 23: 1078-1082.
47. Tang, B., T. Matsuda, S. Akira, N. Nagata, S. Ikehara, T. Hirano, and T. Kishimoto. 1991. Age-associated increase in interleukin 6 in MRL/lpr mice. Int. Immunol. 3: 273-278.
48. Zeuner, R. A., D. M. Klinman, G. Illei, C. Yarboro, K. J. Ishii, M. Gursel, and D. Verthelyi. 2003. Response of peripheral blood mononuclear cells from lupus patients to stimulation by CpG oligodeoxynucleotides. Rheumatology (Oxford). 42: 563-569.
49. Lai, K. N., J. C. Leung, K. B. Lai, K. C. Wong, and C. K. Lai. 1996. Upregulation of adhesion molecule expression on endothelial cells by anti-DNA autoantibodies in systemic lupus erythematosus. Clin. Immunol. Immunopathol. 81: 229-238.
50. Lai, K. N., J. C. Leung, K. B. Lai, F. M. Lai, and K. C. Wong. 1996. Increased release of von Willebrand factor antigen from endothelial cells by anti-DNA autoantibodies. Ann. Rheum Dis. 55: 57-62.
51. Neng Lai, K., J. C. Leung, K. Bik Lai, P. K. Li, and C. K. Lai. 1996. Anti-DNA autoantibodies stimulate the release of interleukin-1 and interleukin-6 from endothelial cells. J. Pathol. 178: 451-457.
52. Kuroiwa, T., E. G. Lee, C. L. Danning, G. G. Illei, I. B. McInnes, and D. T. Boumpas. 1999. CD40 ligand-activated human monocytes amplify glomerular inflammatory responses through soluble and cell-to-cell contact-dependent mechanisms. J. Immunol. 163: 2168-2175.
53. Yu, C. L., K. H. Sun, C. Y. Tsai, S. C. Hsieh, and H. S. Yu. 2001. Anti-dsDNA antibody up-regulates interleukin 6, but not cyclo-oxygenase, gene expression in glomerular mesangial cells: a marker of immune-mediated renal damage? Inflamm. Res. 50: 12-18.
54. Takemura, T., K. Yoshioka, K. Murakami, N. Akano, M. Okada, N. Aya, and S. Maki. 1994. Cellular localization of inflammatory cytokines in human glomerulonephritis. Virchows Arch. 424: 459-464.
55. 1 mice. J. Clin. Invest. 94: 585-591.
56. 1 mice. Am. J. Pathol. 144: 927-937.
57. Tomita, M., B. J. Holman, L. S. Williams, K. C. Pang, and T. J. Santoro. 2001. Cerebellar dysfunction is associated with overexpression of proinflammatory cytokine genes in lupus. J. Neurosci. Res. 64: 26-33.
58. Cooke, M. P., A. W. Heath, K. M. Shokat, Y. Zeng, F. D. Finkelman, P. S. Linsley, M. Howard, and C. C. Goodnow. 1994. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179: 425-438.
59. Healy, J. I., R. E. Dolmetsch, L. A. Timmerman, J. G. Cyster, M. L. Thomas, G. R. Crabtree, R. S. Lewis, and C. C. Goodnow. 1997. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 6: 419-428.
60. Vilen, B. J., T. Nakamura, and J. C. Cambier. 1999. Antigen-stimulated dissociation of BCR mIg from Ig-α/Ig-β: implications for receptor desensitization. Immunity 10 239-248.
61. Leadbetter, E. A., I. R. Rifkin, A. M. Hohlbaum, B. C. Beaudette, M. J. Shlomchik, and A. Marshak-Rothstein. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607.
62. Rui, L., C. G. Vinuesa, J. Blasioli, and C. C. Goodnow. 2003. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat. Immunol. 4: 594-600.