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Volumn 13, Issue 5, 2007, Pages 521-529

The Synthetic Triterpenoid, CDDO, Suppresses Alloreactive T Cell Responses and Reduces Murine Early Acute Graft-versus-Host Disease Mortality

Author keywords

Allogeneic hematopoietic stem cell transplantation (allo HSCT); Mixed lymphocyte responses

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; TRITERPENOID;

EID: 34247155249     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2006.12.453     Document Type: Article
Times cited : (14)

References (24)
  • 1
    • 32544453971 scopus 로고    scopus 로고
    • Shared biology of GVHD and GVT effects: potential methods of separation
    • Fowler D.H. Shared biology of GVHD and GVT effects: potential methods of separation. Crit Rev Oncol Hematol. 57 (2006) 225-244
    • (2006) Crit Rev Oncol Hematol. , vol.57 , pp. 225-244
    • Fowler, D.H.1
  • 2
    • 2442704367 scopus 로고    scopus 로고
    • Significance of selectively targeted apoptotic rete cells in graft-versus-host disease
    • Murphy G.F., and Korngold R. Significance of selectively targeted apoptotic rete cells in graft-versus-host disease. Biol Blood Marrow Transplant 10 (2004) 357-365
    • (2004) Biol Blood Marrow Transplant , vol.10 , pp. 357-365
    • Murphy, G.F.1    Korngold, R.2
  • 3
    • 33644821494 scopus 로고    scopus 로고
    • Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD)
    • Blazar B.R., and Murphy W.J. Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD). Philos Trans R Soc Lond B Biol Sci. 360 (2005) 1747-1767
    • (2005) Philos Trans R Soc Lond B Biol Sci. , vol.360 , pp. 1747-1767
    • Blazar, B.R.1    Murphy, W.J.2
  • 4
    • 30344461633 scopus 로고    scopus 로고
    • Pathophysiology of graft-versus-host disease
    • Ferrara J.L., and Reddy P. Pathophysiology of graft-versus-host disease. Semin Hematol. 43 (2006) 3-10
    • (2006) Semin Hematol. , vol.43 , pp. 3-10
    • Ferrara, J.L.1    Reddy, P.2
  • 5
    • 33747882197 scopus 로고    scopus 로고
    • The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway
    • Ray D.M., Morse K.M., Hilchey S.P., et al. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway. Exp Hematol. 34 (2006) 1201-1210
    • (2006) Exp Hematol. , vol.34 , pp. 1201-1210
    • Ray, D.M.1    Morse, K.M.2    Hilchey, S.P.3
  • 6
    • 7444241538 scopus 로고    scopus 로고
    • The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia
    • Konopleva M., Tsao T., Estrov Z., et al. The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia. Cancer Res. 64 (2004) 7927-7935
    • (2004) Cancer Res. , vol.64 , pp. 7927-7935
    • Konopleva, M.1    Tsao, T.2    Estrov, Z.3
  • 7
    • 4444281592 scopus 로고    scopus 로고
    • Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid
    • Ikeda T., Nakata Y., Kimura F., et al. Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid. Mol Cancer Ther. 3 (2004) 39-45
    • (2004) Mol Cancer Ther. , vol.3 , pp. 39-45
    • Ikeda, T.1    Nakata, Y.2    Kimura, F.3
  • 8
    • 0242643655 scopus 로고    scopus 로고
    • Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL
    • Suh W.S., Kim Y.S., Schimmer A.D., et al. Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL. Leukemia 17 (2003) 2122-2129
    • (2003) Leukemia , vol.17 , pp. 2122-2129
    • Suh, W.S.1    Kim, Y.S.2    Schimmer, A.D.3
  • 9
    • 22344451742 scopus 로고    scopus 로고
    • 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways
    • Chintharlapalli S., Papineni S., Konopleva M., et al. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. Mol Pharmacol. 68 (2005) 119-128
    • (2005) Mol Pharmacol. , vol.68 , pp. 119-128
    • Chintharlapalli, S.1    Papineni, S.2    Konopleva, M.3
  • 10
    • 0035127894 scopus 로고    scopus 로고
    • Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury
    • Nakajima A., Wada K., Miki H., et al. Endogenous PPAR gamma mediates anti-inflammatory activity in murine ischemia-reperfusion injury. Gastroenterology 120 (2001) 460-469
    • (2001) Gastroenterology , vol.120 , pp. 460-469
    • Nakajima, A.1    Wada, K.2    Miki, H.3
  • 11
    • 1542313910 scopus 로고    scopus 로고
    • Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients
    • Schmidt S., Moric E., Schmidt M., et al. Anti-inflammatory and antiproliferative actions of PPAR-gamma agonists on T lymphocytes derived from MS patients. J Leukoc Biol. 75 (2004) 478-485
    • (2004) J Leukoc Biol. , vol.75 , pp. 478-485
    • Schmidt, S.1    Moric, E.2    Schmidt, M.3
  • 12
    • 33748319436 scopus 로고    scopus 로고
    • Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis
    • Rollins M.D., Sudarshan S., Firpo M.A., et al. Anti-inflammatory effects of PPAR-gamma agonists directly correlate with PPAR-gamma expression during acute pancreatitis. J Gastrointest Surg. 10 (2006) 1120-1130
    • (2006) J Gastrointest Surg. , vol.10 , pp. 1120-1130
    • Rollins, M.D.1    Sudarshan, S.2    Firpo, M.A.3
  • 13
    • 3242728823 scopus 로고    scopus 로고
    • A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitis
    • Minns L.A., Buzoni-Gatel D., Ely K.H., et al. A novel triterpenoid induces transforming growth factor beta production by intraepithelial lymphocytes to prevent ileitis. Gastroenterology 127 (2004) 119-126
    • (2004) Gastroenterology , vol.127 , pp. 119-126
    • Minns, L.A.1    Buzoni-Gatel, D.2    Ely, K.H.3
  • 14
    • 0030460772 scopus 로고    scopus 로고
    • Contributions of donor CD4 and CD8 cells to liver injury during murine graft-versus-host disease
    • Li J., Helm K., and Howell C.D. Contributions of donor CD4 and CD8 cells to liver injury during murine graft-versus-host disease. Transplantation 62 (1996) 1621-1628
    • (1996) Transplantation , vol.62 , pp. 1621-1628
    • Li, J.1    Helm, K.2    Howell, C.D.3
  • 15
    • 0033555614 scopus 로고    scopus 로고
    • A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity
    • Suh N., Wang Y., Honda T., et al. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res. 59 (1999) 336-341
    • (1999) Cancer Res. , vol.59 , pp. 336-341
    • Suh, N.1    Wang, Y.2    Honda, T.3
  • 16
    • 0032491276 scopus 로고    scopus 로고
    • Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages
    • Honda T., Rounds B.V., Gribble G.W., et al. Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages. Bioorg Med Chem Lett. 8 (1998) 2711-2714
    • (1998) Bioorg Med Chem Lett. , vol.8 , pp. 2711-2714
    • Honda, T.1    Rounds, B.V.2    Gribble, G.W.3
  • 17
    • 0037053358 scopus 로고    scopus 로고
    • The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells
    • Stadheim T.A., Suh N., Ganju N., et al. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. J Biol Chem. 277 (2002) 16448-16455
    • (2002) J Biol Chem. , vol.277 , pp. 16448-16455
    • Stadheim, T.A.1    Suh, N.2    Ganju, N.3
  • 18
    • 24744447794 scopus 로고    scopus 로고
    • TGF-beta in allogeneic stem cell transplantation: friend or foe?
    • Banovic T., MacDonald K.P., Morris E.S., et al. TGF-beta in allogeneic stem cell transplantation: friend or foe?. Blood 106 (2005) 2206-2214
    • (2005) Blood , vol.106 , pp. 2206-2214
    • Banovic, T.1    MacDonald, K.P.2    Morris, E.S.3
  • 19
    • 29844432142 scopus 로고    scopus 로고
    • Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansion
    • Kleinclauss F., Perruche S., Masson E., et al. Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansion. Cell Death Differ. 13 (2006) 41-52
    • (2006) Cell Death Differ. , vol.13 , pp. 41-52
    • Kleinclauss, F.1    Perruche, S.2    Masson, E.3
  • 20
    • 12444337488 scopus 로고    scopus 로고
    • The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo
    • Place A.E., Suh N., Williams C.R., et al. The novel synthetic triterpenoid, CDDO-imidazolide, inhibits inflammatory response and tumor growth in vivo. Clin Cancer Res. 9 (2003) 2798-2806
    • (2003) Clin Cancer Res. , vol.9 , pp. 2798-2806
    • Place, A.E.1    Suh, N.2    Williams, C.R.3
  • 21
    • 30444458109 scopus 로고    scopus 로고
    • NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145
    • Vodanovic-Jankovic S., Hari P., Jacobs P., et al. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood 107 (2006) 827-834
    • (2006) Blood , vol.107 , pp. 827-834
    • Vodanovic-Jankovic, S.1    Hari, P.2    Jacobs, P.3
  • 22
    • 27644477944 scopus 로고    scopus 로고
    • Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity
    • Sun K., Wilkins D.E., Anver M.R., et al. Differential effects of proteasome inhibition by bortezomib on murine acute graft-versus-host disease (GVHD): delayed administration of bortezomib results in increased GVHD-dependent gastrointestinal toxicity. Blood 106 (2005) 3293-3299
    • (2005) Blood , vol.106 , pp. 3293-3299
    • Sun, K.1    Wilkins, D.E.2    Anver, M.R.3
  • 23
    • 0030861750 scopus 로고    scopus 로고
    • Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines
    • Hill G.R., Crawford J.M., Cooke K.R., et al. Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines. Blood 90 (1997) 3204-3213
    • (1997) Blood , vol.90 , pp. 3204-3213
    • Hill, G.R.1    Crawford, J.M.2    Cooke, K.R.3
  • 24
    • 0038587747 scopus 로고    scopus 로고
    • The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion
    • Chen L.W., Egan L., Li Z.W., et al. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 9 (2003) 575-581
    • (2003) Nat Med. , vol.9 , pp. 575-581
    • Chen, L.W.1    Egan, L.2    Li, Z.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.