Effect of lidamycin on mitochondria initiated apoptotic pathway in human cancer cells

Yaoxue Xuebao

Volumn 42, Issue 2, 2007, Pages 132-138

  Qiu, Qiang ^b   Wang, Zhen ^a   Jiang, Jian Ming ^a   Li, Dian Dong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b General Hospital PLA   (China)

Author keywords

Apoptosis; Lidamycin; Mitochondria; Tumor

Indexed keywords

AMINOGLYCOSIDE; ANTIBIOTIC C 1027; ANTINEOPLASTIC ANTIBIOTIC; BENZYLOXYCARBONYLVALYL ALANYL ASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLVALYL-ALANYL-ASPARTYL FLUOROMETHYL KETONE; CASPASE; CYTOCHROME C; ENEDIYNE; MESSENGER RNA; PEPTIDE CHLOROMETHYL KETONE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CYTOSOL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

AMINO ACID CHLOROMETHYL KETONES; AMINOGLYCOSIDES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CASPASES; CELL LINE, TUMOR; CYTOCHROMES C; CYTOSOL; ENEDIYNES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34247107995     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Zhen YS, Ming XY, Yu B, et al. A new macromoleculer antitumor antibiotic, C-1027 III. Antitumor activity [J]. J Antibiot (Tokyo), 1989,42:1294-1298.
2. Zhen YS, Xue YC, Shao RG. Antitumor activity of the new enediyne antibiotic C1027 [J]. Chin J Antibiot 1994,19:164-168.
3. Xu YJ, Zhen YS, Goldberg IH. C1027 chromophore, a potent new enediyne antitumor antibiotic, induces sequence-specific double-strand DNA cleavage [J]. Biochemistry, 1994,33;5947-5954.
4. McHugh MM, Gawron LS, Matsui S, et al. The antitumor enediyne C-1027 alters cell cycle progression and induces chromosomal aberrations and telomere dysfunction [J]. Cancer Res, 2005,65:5344-5350.
5. Cui DP, Wang Z, Li DD. Effect of lidamycin on the expression of genes involved in invasion regulation in HCT-8 human colon cancer cells [J]. Acta Pharm Sin, 2001,36:246-249.
6. He QY, Liang YY, Wang DS, et al. Characteristics of mitotic cell death induced by enediyne antibiotic lidamycin in human epithelial tumor cells [J]. Int J Oncol, 2002,20:261-266.
7. Wang Z, He Q, Liang Y, et al. Non-caspase-mediated apoptosis contributes to the potent cytotoxicity of the enediyne antibiotic lidamycin toward human tumor cells [J]. Biochem Pharmacol, 2003,65:1767-1775.
8. Wang X. The expanding role of mitochondira in apoptosis [J]. Genes Dev, 2001,15:2922-2933.
9. Ricci JE. Mitochondrial functions during cell death, a complex (I-V) dilemma [J]. Cell Death Differ, 2003,10:488-492.
10. Hengartner MO. The biochemistry of apoptosis [J]. Nature, 2000,407:770-776.
11. Lindsten T, Ross AJ, King A, et al. The combined functions of proapoptotic Bcl-2 family members bak-and bax are essential for normal development of multiple tissues [J]. Mol Cell, 2000,6:1389-1399.
12. Milosevic J, Hoffarth S, Huber C, et al. The DNA damage-induced decrease of Bcl-2 is secondary to the activation of apoptotic effector caspases [J]. Oncogene, 2003,22:6852-6856.
13. LI PF, Dietz R, von Harsdorf R. p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c-independent apoptosis blocked by Bcl-2 [J]. EMBO J, 1999,18:6027-6036.
14. Renner K, Amberger A, Konwalinka G, et al. Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells [J]. Biochim Biophys Acta, 2003,1642:115-123.
15. Sun Y. p53 and its downstream proteins as molecular targets of cancer [J]. Mol Carcinog, 2006,45:409-415.
16. Kho PS, Wang Z, Zhuang L, et al. p53-Regulated transcriptional program associated with genotoxic stress-induced apoptosis [J]. J Biol Chem, 2004,279:21183-21192.
17. Chipuk JE, Kuwana T, Bouchier-Hayes L, et al. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis [J]. Science, 2004,303:1010-1014.
18. Mihara M, Enter S, Zaika A, et al. P53 has a direct apoptogenic role at the mitochondria [J]. Mol Cell, 2003,11:577-590.
19. Konishi A, Shimizu S, Hirota J, et al. Involvement of histone H1.2 in apoptosis induced by DNA double-strand breaks [J]. Cell, 2003,114:673-688.