Cyclooxygenase-2 induction by Arsenite through the IKKβ/NFκB pathway exerts an antiapoptotic effect in mouse epidermal Cl41 cells

Environmental Health Perspectives

Volumn 115, Issue 4, 2007, Pages 513-518

  Ouyang, Weiming ^a   Zhang, Dongyun ^a   Ma, Qian ^a   Li, Jingxia ^a   Huang, Chuanshu ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Arsenite; Carcinogenesis; COX 2; NF B

Indexed keywords

ARSENIC TRIOXIDE; CYCLOOXYGENASE 2; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LUCIFERASE; SMALL INTERFERING RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; EMBRYO CELL; ENZYME ASSAY; EPIDERMIS CELL; FIBROBLAST; GENE OVEREXPRESSION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SKIN CARCINOGENESIS; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; ARSENITES; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CYCLOOXYGENASE 2; ENVIRONMENTAL POLLUTANTS; EPIDERMIS; I-KAPPA B KINASE; MICE; MICE, KNOCKOUT; NF-KAPPA B; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 34247095740     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.9588     Document Type: Article

References (58)

1. Abrams JM. 2002. Competition and compensation: coupled to death in development and cancer. Cell 110(4):403-406.
2. Ambion Inc. 2006a. siRNA Target Finder. Available: http://www.ambion.com/ techlib/misc/siRNA_finder.html [accessed 15 February 2007].
3. Ambion Inc. 2006b. siRNA Design Guidelines. Available: http://www.ambion.com/techlib/tb/tb_506.html [accessed 15 February 2007].
4. Bartke T, Siegmund D, Peters N, Reichwein M, Henkler F, Scheurich P, et al. 2001. p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. Oncogene 20(5):571-580.
5. Bettley FR, O'Shea JA. 1975. The absorption of arsenic and its relation to carcinoma. Br J Dermatol 92(5):563-568.
6. Budunova IV, Perez P, Vaden VR, Spiegelman VS, Slaga TJ, Jorcano JL. 1999. Increased expression of p50-NF-κB and constitutive activation of NF-κB transcription factors during mouse skin carcinogenesis. Oncogene 18(52):7423-7431.
7. Ding J, Li J, Xue C, Wu K, Ouyang W, Zhang D, et al. 2006. Cyclooxygenase-2 Induction by arsenite is through a nuclear factor of activated T-cell-dependent pathway and plays an antiapoptotic role in Beas-2B cells. J Biol Chem 281(34):24405-24413.
8. Feng L, Sun W, Xia Y, Tang WW, Chanmugam P, Soyoola E, et al. 1993. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch Biochem Biophys 307(2):361-368.
9. Fischer SM, Lo HH, Gordon GB, Seibert K, Kelloff G, Lubet RA, et al. 1999. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol Carcinog 25(4):231-240.
10. Han JA, Kim JI, Ongusaha PP, Hwang DH, Ballou LR, Mahale A, et al. 2002. P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosis. Embo J 21(21):5635-5644.
11. Han SS, Kim K, Hahm ER, Park CH, Kimler BF, Lee SJ, et al. 2005. Arsenic trioxide represses constitutive activation of NF-κB and COX-2 expression in human acute myeloid leukemia, HL-60. J Cell Biochem 94(4):695-707.
12. Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100(1):57-70.
13. Haque R, Mazumder DN, Samanta S, Ghosh N, Kalman D, Smith MM, et al. 2003. Arsenic in drinking water and skin lesions: dose-response data from West Bengal, India. Epidemiology 14(2):174-182.
14. Hecker E. 1987. Three stage carcinogenesis in mouse skin - recent results and present status of an advanced model system of chemical carcinogenesis. Toxicol Pathol 15(2):245-258.
15. Hickman JA. 2002. Apoptosis and tumourigenesis. Curr Opin Genet Dev 12(1):67-72.
16. Ho IC, Lee TC. 2002. Arsenite pretreatment attenuates benzo[a]-pyrene cytotoxicity in a human lung adenocarcinoma cell line by decreasing cyclooxygenase-2 levels. J Toxicol Environ Health A 65(3-4):245-263.
17. Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M. 2002. Transcriptional repression of the anti-apoptotic survivin gene by wild type p53. J Biol Chem 277(5):3247-3257.
18. Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, et al. 1999. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284(5412):316-320.
19. Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. 2001. IKKα controls formation of the epidermis independently of NF-κB. Nature 410(6829):710-714.
20. Huang C, Ke Q, Costa M, Shi X. 2004. Molecular mechanisms of arsenic carcinogenesis. Mol Cell Biochem 255(1-2):57-66.
21. IARC (International Agency for Research on Cancer). 1980. Some Metals and Metallic Compounds. IARC Monogr Eval Carcinog Risk Chem Man 23:1-438.
22. Johnstone RW, Ruefli AA, Lowe SW. 2002. Apoptosis: a link between cancer genetics and chemotherapy. Cell 108(2):153-164.
23. Klement JF, Rice NR, Car BD, Abbondanzo SJ, Powers GD, Bhatt PH, et al. 1996. IκBα deficiency results in a sustained NF-κB response and severe widespread dermatitis in mice. Mol Cell Biol 16(5):2341-2349.
24. 2 activates mitogen-activated protein kinase/ Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer Res 65(14):6275-6281.
25. Landolph JR. 1994. Molecular mechanisms of transformation of C3H/10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds. Environ Health Perspect 102(suppl 3):119-125.
26. Li J, Chen H, Ke Q, Feng Z, Tang MS, Liu B, et al. 2004. Differential effects of polycyclic aromatic hydrocarbons on transactivation of AP-1 and NF-κB in mouse epidermal cl41 cells. Mol Carcinog 40(2):104-115.
27. Li Q, Lu Q, Hwang JY, Buscher D, Lee KF, Izpisua-Belmonte JC, et al. 1999. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev 13(10):1322-1328.
28. Liu XH, Yao S, Kirschenbaum A, Levine AC. 1998. NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells. Cancer Res 58(19):4245-4249.
29. Lowe SW, Lin AW. 2000. Apoptosis in cancer. Carcinogenesis 21(3):485-495.
30. National Center for Biotechnology Information. 2006a. BLAST (Basic Local Alignment Search Tool). Available: http://www.ncbi.nlm.nih.gov/BLAST/ [accessed 15 February 2007].
31. National Center for Biotechnology Information. 2006b. GenBank. Available: http://www.ncbi.nlm.nih.gov/Genbank/index.html [accessed 15 February 2007].
32. National Research Council. 1999. Arsenic in Drinking Water. Washington, DC:National Academy Press.
33. Nriagu JO. 2002. Environmental Chemistry of Arsenic. New York:Dekker.
34. Ouyang W, Li J, Ma Q, Huang C. 2006. Essential roles of PI-3K/Akt/ IKKβ/ NFκB pathway in cyclin D1 induction by arsenite in JB6 Cl41 cells. Carcinogenesis 27(4):864-873.
35. Pasparakis M, Courtois G, Hafner M, Schmidt-Supprian M, Nenci A, Toksoy A, et al. 2002. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature 417(6891):861-866.
36. Pi J, He Y, Bortner C, Huang J, Liu J, Zhou T, et al. 2005. Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis in cultured human keratinocytes: potential role in skin co-carcinogenesis. Int J Cancer 116(1):20-26.
37. Rossman TG. 2003. Mechanism of arsenic carcinogenesis: an integrated approach. Mutat Res 533(1-2):37-65.
38. Ryan KM, Phillips AC, Vousden KH. 2001. Regulation and function of the p53 tumor suppressor protein. Curr Opin Cell Biol 13(3):332-337.
39. Seitz CS, Lin Q, Deng H, Khavari PA. 1998. Alterations in NF-κB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-κB. Proc Natl Acad Sci USA 95(5):2307-2312.
40. 2 increases growth and motility of colorectal carcinoma cells. J Biol Chem 276(21):18075-18081.
41. Smith WL, Garavito RM, DeWitt DL. 1996. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271(52):33157-33160.
42. Song L, Li J, Zhang D, Liu ZG, Ye J, Zhan Q, et al. 2006. IKKβ programs to turn on the GADD45α-MKK4-JNK apoptotic cascade specifically via p50 NF-κB in arsenite response. J Cell Biol 175(4):607-617.
43. Subbaramaiah K, Bulic P, Lin Y, Dannenberg AJ, Pasco DS. 2001. Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription. J Biomol Screen 6(2):101-110.
44. Sun Y, Tang XM, Half E, Kuo MT, Sinicrope FA. 2002. Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res 62(21):6323-6328.
45. Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, et al. 2002. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 62(12):3395-3401.
46. Trouba KJ, Germolec DR. 2004. Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes. Toxicol Sci 79(2):248-257.
47. Tsai SH, Liang YC, Chen L, Ho FM, Hsieh MS, Lin JK. 2002. Arsenite stimulates cyclooxygenase-2 expression through activating IκB kinase and nuclear factor κB in primary and ECV304 endothelial cells. J Cell Biochem 84(4):750-758.
48. Tseng WP, Chu HM, How SW, Fong JM, Lin CS, Yeh S. 1968. Prevalence of skin cancer in an endemic area of chronic arsenicism in Taiwan. J Natl Cancer Inst 40(3):453-463.
49. Tsujii M, DuBois RN. 1995. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83(3):493-501.
50. Tsujii M, Kawano S, DuBois RN. 1997. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 94(7):3336-3340.
51. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. 1998. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93(5):705-716.
52. 2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade. Cancer Res 65(5):1822-1829.
53. Wu Y, Mehew JW, Heckman CA, Arcinas M, Boxer LM. 2001. Negative regulation of bcl-2 expression by p53 in hematopoietic cells. Oncogene 20(2):240-251.
54. Yan Z, Subbaramaiah K, Camilli T, Zhang F, Tanabe T, McCaffrey TA, et al. 2000. Benzo[a]pyrene induces the transcription of cyclooxygenase-2 in vascular smooth muscle cells. Evidence for the involvement of extracellular signal-regulated kinase and NF-κB. J Biol Chem 275(7):4949-4955.
55. Yang C, Frenkel K. 2002. Arsenic-mediated cellular signal transduction, transcription factor activation, and aberrant gene expression: implications in carcinogenesis. J Environ Pathol Toxicol Oncol 21(4):331-342.
56. Yu HS, Liao WT, Chai CY. 2006. Arsenic carcinogenesis in the skin. J Biomed Sci 13(5):657-666.
57. Zornig M, Hueber A, Baum W, Evan G. 2001. Apoptosis regulators and their role in tumorigenesis. Biochim Biophys Acta 1551(2):F1-37.
58. Zoumpourlis V, Solakidi S, Papathoma A, Papaevangeliou D. 2003. Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis. Carcinogenesis 24(7):1159-1165.