Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR- rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats

Epilepsia

Volumn 48, Issue 4, 2007, Pages 631-645

  Hoffmann, Katrin ^a   Löscher, Wolfgang ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

Blood brain barrier; Efflux transporters; Epilepsy; Multidrug resistance protein; Phenytoin

Indexed keywords

CARBAMAZEPINE; DIAZEPAM; FELBAMATE; GLYCOPROTEIN P; LAMOTRIGINE; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN 2; PHENOBARBITAL; PHENYTOIN; PROBENECID; TARIQUIDAR; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; DRUG TRANSPORT; ENDOTHELIUM CELL; FEMALE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEIZURE; STAINING; STATISTICAL SIGNIFICANCE; UPREGULATION; WILD TYPE;

ANIMALS; ANTIBODIES, MONOCLONAL; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARIES; DRUG RESISTANCE, MULTIPLE; ENDOTHELIUM, VASCULAR; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; LIVER; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEINS; PHENYTOIN; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; SEIZURES; UP-REGULATION;

EID: 34247093310     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2006.00939.x     Document Type: Article

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