Brain Access and Anticonvulsant Efficacy of Carbamazepine, Lamotrigine, and Felbamate in ABCC2/MRP2-Deficient TR- Rats

Epilepsia

Volumn 44, Issue 12, 2003, Pages 1479-1486

  Potschka, Heidrun ^a   Fedrowitz, Maren ^a   Löscher, Wolfgang ^a  

^a UNIVERSITY OF VETERINARY MEDICINE HANNOVER   (Germany)

Author keywords

ABCC2; Antiepileptic drugs; Epilepsy; Multidrug resistance protein; Pharmacoresistance

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTICONVULSIVE AGENT; CARBAMAZEPINE; FELBAMATE; LAMOTRIGINE; MULTIDRUG RESISTANCE PROTEIN 2; PHENOBARBITAL; PHENYTOIN; PROTEIN ABCC2; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DISEASE MODEL; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG PENETRATION; DRUG RESPONSE; ENDOTHELIUM CELL; EPILEPSY; EPILEPTIC FOCUS; EPILEPTIC NERVE CELL; EXTRACELLULAR SPACE; FEMALE; KINDLING; MICRODIALYSIS; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

AMYGDALA; ANIMALS; ANTICONVULSANTS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; CARBAMAZEPINE; CEREBRAL CORTEX; DRUG RESISTANCE, MULTIPLE; ELECTROENCEPHALOGRAPHY; ENDOTHELIUM, VASCULAR; EPILEPSY; FEMALE; KINDLING, NEUROLOGIC; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROPYLENE GLYCOLS; RATS; RATS, MUTANT STRAINS; RATS, WISTAR; TRIAZINES;

EID: 0347364703     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0013-9580.2003.22603.x     Document Type: Article

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