-
1
-
-
0028912254
-
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
-
Finkel TH, Tudor-Williams G, Banda NK, et al.: Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med 1995, 1:129-134.
-
(1995)
Nat Med
, vol.1
, pp. 129-134
-
-
Finkel, T.H.1
Tudor-Williams, G.2
Banda, N.K.3
-
2
-
-
0026517545
-
Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals
-
Groux H, Torpier G, Monte D, et al.: Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992, 175:331-340.
-
(1992)
J Exp Med
, vol.175
, pp. 331-340
-
-
Groux, H.1
Torpier, G.2
Monte, D.3
-
3
-
-
0026667222
-
Programmed death of T cells in HIV-1 infection
-
Meyaard L, Otto SA, Jonker RR, et al.: Programmed death of T cells in HIV-1 infection. Science 1992, 257:217-219.
-
(1992)
Science
, vol.257
, pp. 217-219
-
-
Meyaard, L.1
Otto, S.A.2
Jonker, R.R.3
-
4
-
-
0037343278
-
Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
-
Silvestri G, Sodora DL, Koup RA, et al.: Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 2003, 18:441-452.
-
(2003)
Immunity
, vol.18
, pp. 441-452
-
-
Silvestri, G.1
Sodora, D.L.2
Koup, R.A.3
-
5
-
-
0022487032
-
Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization
-
Harper ME, Marselle LM, Gallo RC, Wong-Staal F: Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization. Proc Natl Acad Sci U S A 1986, 83:772-776.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 772-776
-
-
Harper, M.E.1
Marselle, L.M.2
Gallo, R.C.3
Wong-Staal, F.4
-
6
-
-
0023694580
-
AIDS as immune system activation: A model for pathogenesis
-
Ascher MS, Sheppard HW: AIDS as immune system activation: a model for pathogenesis. Clin Exp Immunol 1988, 73:165-167.
-
(1988)
Clin Exp Immunol
, vol.73
, pp. 165-167
-
-
Ascher, M.S.1
Sheppard, H.W.2
-
7
-
-
19344370239
-
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
-
Papagno L, Spina CA, Marchant A, et al.: Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol 2004, 2:E20.
-
(2004)
PLoS Biol
, vol.2
-
-
Papagno, L.1
Spina, C.A.2
Marchant, A.3
-
8
-
-
4043102575
-
CD8+ T cells specific for EBV, cytomegalovirus, and influenza virus are activated during primary HIV infection
-
This study demonstrates that HIV infection is associated with widespread activation of T cells, not just those specific for HIV
-
Doisne JM, Urrutia A, Lacabaratz-Porret C, et al.: CD8+ T cells specific for EBV, cytomegalovirus, and influenza virus are activated during primary HIV infection. J Immunol 2004, 173:2410-248. This study demonstrates that HIV infection is associated with widespread activation of T cells, not just those specific for HIV.
-
(2004)
J Immunol
, vol.173
, pp. 2410-2248
-
-
Doisne, J.M.1
Urrutia, A.2
Lacabaratz-Porret, C.3
-
9
-
-
0036103096
-
CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?
-
Grossman Z, Meier-Schellersheim M, Sousa AE, et al.: CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause? Nat Med 2002, 8:319-323.
-
(2002)
Nat Med
, vol.8
, pp. 319-323
-
-
Grossman, Z.1
Meier-Schellersheim, M.2
Sousa, A.E.3
-
10
-
-
0041327667
-
Persistent immune activation in HIV-1 infection is associated with progression to AIDS
-
Hazenberg MD, Otto SA, van Benthem BH, et al.: Persistent immune activation in HIV-1 infection is associated with progression to AIDS. AIDS 2003, 17:1881-1888.
-
(2003)
AIDS
, vol.17
, pp. 1881-1888
-
-
Hazenberg, M.D.1
Otto, S.A.2
van Benthem, B.H.3
-
11
-
-
0037232212
-
Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions
-
Tesselaar K, Arens R, van Schijndel GM, et al.: Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Nat Immunol 2003, 4:49-54.
-
(2003)
Nat Immunol
, vol.4
, pp. 49-54
-
-
Tesselaar, K.1
Arens, R.2
van Schijndel, G.M.3
-
12
-
-
33748416499
-
-
Suntharalingam G, Perry MR, Ward S, et al.: Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006, 355:1018-1028. This unfortunate and controversial study demonstrated that widespread non-antigen-specific T-cell activation in humans causes CD4+ T-cell depletion in the absence of HIV.
-
Suntharalingam G, Perry MR, Ward S, et al.: Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006, 355:1018-1028. This unfortunate and controversial study demonstrated that widespread non-antigen-specific T-cell activation in humans causes CD4+ T-cell depletion in the absence of HIV.
-
-
-
-
13
-
-
4644342929
-
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
-
Brenchley JM, Schacker TW, Ruff LE, et al.: CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004, 200:749-759.
-
(2004)
J Exp Med
, vol.200
, pp. 749-759
-
-
Brenchley, J.M.1
Schacker, T.W.2
Ruff, L.E.3
-
14
-
-
0142092389
-
Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy
-
Guadalupe M, Reay E, Sankaran S, et al.: Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol 2003, 77:11708-11717.
-
(2003)
J Virol
, vol.77
, pp. 11708-11717
-
-
Guadalupe, M.1
Reay, E.2
Sankaran, S.3
-
15
-
-
4644289983
-
Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract
-
Mehandru S, Poles MA, Tenner-Racz K, et al.: Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004, 200:761-770.
-
(2004)
J Exp Med
, vol.200
, pp. 761-770
-
-
Mehandru, S.1
Poles, M.A.2
Tenner-Racz, K.3
-
16
-
-
0032188878
-
Immunologic effects of combined protease inhibitor and reverse transcriptase inhibitor therapy in previously treated chronic HIV-1 infection
-
Giorgi JV, Majchrowicz MA, Johnson TD, et al.: Immunologic effects of combined protease inhibitor and reverse transcriptase inhibitor therapy in previously treated chronic HIV-1 infection. AIDS 1998, 12:1833-1844.
-
(1998)
AIDS
, vol.12
, pp. 1833-1844
-
-
Giorgi, J.V.1
Majchrowicz, M.A.2
Johnson, T.D.3
-
17
-
-
0031042433
-
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
-
Bleul CC, Wu L, Hoxie JA, et al.: The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci U S A 1997, 94:1925-1930.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 1925-1930
-
-
Bleul, C.C.1
Wu, L.2
Hoxie, J.A.3
-
18
-
-
0030987288
-
CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro
-
Wu L, Paxton WA, Kassam N, et al.: CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J Exp Med 1997, 185:1681-1691.
-
(1997)
J Exp Med
, vol.185
, pp. 1681-1691
-
-
Wu, L.1
Paxton, W.A.2
Kassam, N.3
-
19
-
-
0030055293
-
Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway
-
Shattock RJ, Rizzardi GP, Hayes P, Griffin GE: Engagement of adhesion molecules (CD18, CD11a, CD45, CD44, and CD58) enhances human immunodeficiency virus type 1 replication in monocytic cells through a tumor necrosis factor-modulated pathway. J Infect Dis 1996, 174:54-62.
-
(1996)
J Infect Dis
, vol.174
, pp. 54-62
-
-
Shattock, R.J.1
Rizzardi, G.P.2
Hayes, P.3
Griffin, G.E.4
-
20
-
-
0023913884
-
Transcription and replication of human immunodeficiency virus-1 in B lymphocytes in vitro
-
Caiman AF, Busch MP, Vyas GN, et al.: Transcription and replication of human immunodeficiency virus-1 in B lymphocytes in vitro. AIDS 1988, 2:185-193.
-
(1988)
AIDS
, vol.2
, pp. 185-193
-
-
Caiman, A.F.1
Busch, M.P.2
Vyas, G.N.3
-
21
-
-
0343755626
-
Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro
-
Kawakami K, Scheidereit C, Roeder RG: Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappa B) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro. Proc Natl Acad Sci U S A 1988, 85:4700-4704.
-
(1988)
Proc Natl Acad Sci U S A
, vol.85
, pp. 4700-4704
-
-
Kawakami, K.1
Scheidereit, C.2
Roeder, R.G.3
-
22
-
-
33644822414
-
Pathogenesis of HIV infection: What the virus spares is as important as what it destroys
-
Grossman Z, Meier-Schellersheim M, Paul WE, Picker LJ: Pathogenesis of HIV infection: what the virus spares is as important as what it destroys. Nat Med 2006, 12:289-295.
-
(2006)
Nat Med
, vol.12
, pp. 289-295
-
-
Grossman, Z.1
Meier-Schellersheim, M.2
Paul, W.E.3
Picker, L.J.4
-
23
-
-
0036801658
-
Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis
-
Schacker TW, Nguyen PL, Beilman GJ, et al.: Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis. J Clin Invest 2002, 110:1133-1139.
-
(2002)
J Clin Invest
, vol.110
, pp. 1133-1139
-
-
Schacker, T.W.1
Nguyen, P.L.2
Beilman, G.J.3
-
24
-
-
27944487152
-
-
Schacker TW, Reilly C, Beilman GJ, et al.: Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS 2005, 19:2169-2171. This study demonstrated that lymphoid tissue fibrosis limits CD4+ T-cell restoration during antiretroviral therapy.
-
Schacker TW, Reilly C, Beilman GJ, et al.: Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS 2005, 19:2169-2171. This study demonstrated that lymphoid tissue fibrosis limits CD4+ T-cell restoration during antiretroviral therapy.
-
-
-
-
25
-
-
0037108969
-
Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapy
-
Schacker TW, Nguyen PL, Martinez E, et al.: Persistent abnormalities in lymphoid tissues of human immunodeficiency virus-infected patients successfully treated with highly active antiretroviral therapy. J Infect Dis 2002, 186:1092-1097.
-
(2002)
J Infect Dis
, vol.186
, pp. 1092-1097
-
-
Schacker, T.W.1
Nguyen, P.L.2
Martinez, E.3
-
26
-
-
0024415190
-
Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor
-
Merrill JE, Koyanagi Y, Chen IS: Interleukin-1 and tumor necrosis factor alpha can be induced from mononuclear phagocytes by human immunodeficiency virus type 1 binding to the CD4 receptor. J Virol 1989, 63:4404-4408.
-
(1989)
J Virol
, vol.63
, pp. 4404-4408
-
-
Merrill, J.E.1
Koyanagi, Y.2
Chen, I.S.3
-
27
-
-
0025954319
-
Recombinant gp120 specifically enhances tumor necrosis factor-alpha production and Ig secretion in B lymphocytes from HIV-infected individuals but not from seronegative donors
-
Rieckmann P, Poli G, Fox CH, et al.: Recombinant gp120 specifically enhances tumor necrosis factor-alpha production and Ig secretion in B lymphocytes from HIV-infected individuals but not from seronegative donors. J Immunol 1991, 147:2922-2927.
-
(1991)
J Immunol
, vol.147
, pp. 2922-2927
-
-
Rieckmann, P.1
Poli, G.2
Fox, C.H.3
-
28
-
-
0032845027
-
HIV-1 Nef mediates lymphocyte Chemotaxis and activation by infected macrophages
-
Swingler S, Mann A, Jacque J, et al.: HIV-1 Nef mediates lymphocyte Chemotaxis and activation by infected macrophages. Nat Med 1999, 5:997-1003.
-
(1999)
Nat Med
, vol.5
, pp. 997-1003
-
-
Swingler, S.1
Mann, A.2
Jacque, J.3
-
29
-
-
33745070227
-
-
Schindler M, Munch J, Kutsch O, et al.: Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006, 125:1055-1067. This study highlights evolutionary changes in the accessory protein nef which may partly explain the ability of HIV to cause generalized T-cell activation and AIDS.
-
Schindler M, Munch J, Kutsch O, et al.: Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell 2006, 125:1055-1067. This study highlights evolutionary changes in the accessory protein nef which may partly explain the ability of HIV to cause generalized T-cell activation and AIDS.
-
-
-
-
30
-
-
15444363618
-
Depletion of regulatory T cells in HIV infection is associated with immune activation
-
This study suggests that regulatory T-cell depletion during HIV infection might be a cause of generalized T-cell activation
-
Eggena MP, Barugahare B, Jones N, et al.: Depletion of regulatory T cells in HIV infection is associated with immune activation. J Immunol 2005, 174:4407-4414. This study suggests that regulatory T-cell depletion during HIV infection might be a cause of generalized T-cell activation.
-
(2005)
J Immunol
, vol.174
, pp. 4407-4414
-
-
Eggena, M.P.1
Barugahare, B.2
Jones, N.3
-
31
-
-
0026333671
-
Cytokines and HIV infection: Is AIDS a tumor necrosis factor disease?
-
Matsuyama T, Kobayashi N, Yamamoto N: Cytokines and HIV infection: is AIDS a tumor necrosis factor disease? AIDS 1991, 5:1405-1417.
-
(1991)
AIDS
, vol.5
, pp. 1405-1417
-
-
Matsuyama, T.1
Kobayashi, N.2
Yamamoto, N.3
-
32
-
-
33645924682
-
-
Brenchley JM, Price DA, Douek DC: HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006, 7:235-239. This review explains the hypothesis that the early loss of gut-associated lymphoid tissue-associated CD4+ T cells may allow for translocation of bacterial products, stimulating innate immune responses and causing generalized T-cell activation.
-
Brenchley JM, Price DA, Douek DC: HIV disease: fallout from a mucosal catastrophe? Nat Immunol 2006, 7:235-239. This review explains the hypothesis that the early loss of gut-associated lymphoid tissue-associated CD4+ T cells may allow for translocation of bacterial products, stimulating innate immune responses and causing generalized T-cell activation.
-
-
-
-
33
-
-
0028858060
-
High correlations of anti-CMV titers with lymphocyte activation status and CD57 antibody-binding capacity as estimated with three-color, quantitative flow cytometry in blood donors
-
Lenkei R, Andersson B: High correlations of anti-CMV titers with lymphocyte activation status and CD57 antibody-binding capacity as estimated with three-color, quantitative flow cytometry in blood donors. Clin Immunol Immunopathol 1995, 77:131-138.
-
(1995)
Clin Immunol Immunopathol
, vol.77
, pp. 131-138
-
-
Lenkei, R.1
Andersson, B.2
-
34
-
-
0033758378
-
Immune responses to hepatitis C and non-hepatitis C antigens in hepatitis C virus infected and HIV-1 coinfected patients
-
Valdez H, Anthony D, Farukhi F, et al.: Immune responses to hepatitis C and non-hepatitis C antigens in hepatitis C virus infected and HIV-1 coinfected patients. AIDS 2000, 14:2239-2246.
-
(2000)
AIDS
, vol.14
, pp. 2239-2246
-
-
Valdez, H.1
Anthony, D.2
Farukhi, F.3
-
35
-
-
0037114944
-
Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression
-
Schacker T, Zeh J, Hu H, et al.: Changes in plasma human immunodeficiency virus type 1 RNA associated with herpes simplex virus reactivation and suppression. J Infect Dis 2002, 186:1718- 1725.
-
(2002)
J Infect Dis
, vol.186
, pp. 1718-1725
-
-
Schacker, T.1
Zeh, J.2
Hu, H.3
-
36
-
-
0032955651
-
Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage
-
Giorgi JV, Hultin LE, McKeating JA, et al.: Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999, 179:859-870.
-
(1999)
J Infect Dis
, vol.179
, pp. 859-870
-
-
Giorgi, J.V.1
Hultin, L.E.2
McKeating, J.A.3
-
37
-
-
0036534655
-
Predictive value of immunologic and virologie markers after long or short duration of HIV-1 infection
-
Giorgi JV, Lyles RH, Matud JL, et al.: Predictive value of immunologic and virologie markers after long or short duration of HIV-1 infection. J Acquir Immune Defic Syndr 2002, 29:346-355.
-
(2002)
J Acquir Immune Defic Syndr
, vol.29
, pp. 346-355
-
-
Giorgi, J.V.1
Lyles, R.H.2
Matud, J.L.3
-
38
-
-
3843056825
-
Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
-
Deeks SG, Kitchen CM, Liu L, et al.: Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load. Blood 2004, 104:942-947.
-
(2004)
Blood
, vol.104
, pp. 942-947
-
-
Deeks, S.G.1
Kitchen, C.M.2
Liu, L.3
-
39
-
-
0038701685
-
T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy
-
Hunt PW, Martin JN, Sinclair E, et al.: T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003, 187:1534-1543.
-
(2003)
J Infect Dis
, vol.187
, pp. 1534-1543
-
-
Hunt, P.W.1
Martin, J.N.2
Sinclair, E.3
-
40
-
-
4744352698
-
Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy
-
Smith K, Aga E, Bosch RJ, et al.: Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy. AIDS 2004, 18:1953-1956.
-
(2004)
AIDS
, vol.18
, pp. 1953-1956
-
-
Smith, K.1
Aga, E.2
Bosch, R.J.3
-
41
-
-
33745214932
-
Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: Association of immune activation, T cell maturation markers, and cellular HIV-1 DNA
-
Goicoechea M, Smith DM, Liu L, et al.: Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA. J Infect Dis 2006, 194:29-37.
-
(2006)
J Infect Dis
, vol.194
, pp. 29-37
-
-
Goicoechea, M.1
Smith, D.M.2
Liu, L.3
-
42
-
-
28844459523
-
CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation
-
Benito JM, Lopez M, Lozano S, et al.: CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation. J Infect Dis 2005, 192:2142-2146.
-
(2005)
J Infect Dis
, vol.192
, pp. 2142-2146
-
-
Benito, J.M.1
Lopez, M.2
Lozano, S.3
-
43
-
-
0037099450
-
Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts
-
Miller V, Phillips AN, Clotet B, et al.: Association of virus load, CD4 cell count, and treatment with clinical progression in human immunodeficiency virus-infected patients with very low CD4 cell counts. J Infect Dis 2002, 186:189-197.
-
(2002)
J Infect Dis
, vol.186
, pp. 189-197
-
-
Miller, V.1
Phillips, A.N.2
Clotet, B.3
-
44
-
-
0035816396
-
Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis
-
Pitrak DL, Bolanos J, Hershow R, Novak RM: Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis. AIDS 2001, 15:1317-1319.
-
(2001)
AIDS
, vol.15
, pp. 1317-1319
-
-
Pitrak, D.L.1
Bolanos, J.2
Hershow, R.3
Novak, R.M.4
-
45
-
-
0036468120
-
CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy
-
Deeks SG, Hoh R, Grant RM, et al: CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy. J Infect Dis 2002, 185:315-323.
-
(2002)
J Infect Dis
, vol.185
, pp. 315-323
-
-
Deeks, S.G.1
Hoh, R.2
Grant, R.M.3
-
46
-
-
0033179343
-
Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo
-
Sloand EM, Kumar PN, Kim S, et al.: Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo. Blood 1999, 94:1021-1027.
-
(1999)
Blood
, vol.94
, pp. 1021-1027
-
-
Sloand, E.M.1
Kumar, P.N.2
Kim, S.3
-
47
-
-
33646883620
-
The independent effect of drug resistance on T cell activation in HIV infection
-
This study demonstrates that some drug resistance mutations may decrease the ability of HIV to cause T-cell activation, independent of effects on viral replication
-
Hunt PW, Deeks SG, Bangsberg DR, et al.: The independent effect of drug resistance on T cell activation in HIV infection. AIDS 2006, 20:691-699. This study demonstrates that some drug resistance mutations may decrease the ability of HIV to cause T-cell activation, independent of effects on viral replication.
-
(2006)
AIDS
, vol.20
, pp. 691-699
-
-
Hunt, P.W.1
Deeks, S.G.2
Bangsberg, D.R.3
-
48
-
-
1842457792
-
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: A novel role of the gp41 cytoplasmic tail
-
Wyma DJ, Jiang J, Shi J, et al.: Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail. J Virol 2004, 78:3429-3435.
-
(2004)
J Virol
, vol.78
, pp. 3429-3435
-
-
Wyma, D.J.1
Jiang, J.2
Shi, J.3
-
49
-
-
0036192919
-
Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy
-
Rizzardi GP, Harari A, Capiluppi B, et al.: Treatment of primary HIV-1 infection with cyclosporin A coupled with highly active antiretroviral therapy. J Clin Invest 2002, 109:681-688.
-
(2002)
J Clin Invest
, vol.109
, pp. 681-688
-
-
Rizzardi, G.P.1
Harari, A.2
Capiluppi, B.3
-
50
-
-
0037084272
-
The extent of HIV-1-related immunodeficiency and age predict the longterm CD4 T lymphocyte response to potent antiretroviral therapy
-
Kaufmann GR, Bloch M, Finlayson R, et al.: The extent of HIV-1-related immunodeficiency and age predict the longterm CD4 T lymphocyte response to potent antiretroviral therapy. AIDS 2002, 16:359-367.
-
(2002)
AIDS
, vol.16
, pp. 359-367
-
-
Kaufmann, G.R.1
Bloch, M.2
Finlayson, R.3
-
51
-
-
0037183954
-
Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease
-
Valdez H, Connick E, Smith KY, et al.: Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease. AIDS 2002 16:1859-1866.
-
(2002)
AIDS
, vol.16
, pp. 1859-1866
-
-
Valdez, H.1
Connick, E.2
Smith, K.Y.3
-
52
-
-
0001027244
-
A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection
-
Davey RT Jr, Chaitt DG, Albert JM, et al.: A randomized trial of high- versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection. J Infect Dis 1999, 179:849-858.
-
(1999)
J Infect Dis
, vol.179
, pp. 849-858
-
-
Davey Jr, R.T.1
Chaitt, D.G.2
Albert, J.M.3
-
53
-
-
0004781509
-
Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: A randomized controlled trial
-
Davey RT Jr, Murphy RL, Graziano FM, et al.: Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: a randomized controlled trial. JAMA 2000, 284:183-189.
-
(2000)
JAMA
, vol.284
, pp. 183-189
-
-
Davey Jr, R.T.1
Murphy, R.L.2
Graziano, F.M.3
-
54
-
-
0013610170
-
Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus
-
Kovacs JA, Vogel S, Albert JM, et al.: Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Engl J Med 1996, 335:1350-1356.
-
(1996)
N Engl J Med
, vol.335
, pp. 1350-1356
-
-
Kovacs, J.A.1
Vogel, S.2
Albert, J.M.3
-
55
-
-
3242773778
-
IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation
-
Sereti I, Anthony KB, Martinez-Wilson H, et al.: IL-2-induced CD4+ T-cell expansion in HIV-infected patients is associated with long-term decreases in T-cell proliferation. Blood 2004, 104:775-780.
-
(2004)
Blood
, vol.104
, pp. 775-780
-
-
Sereti, I.1
Anthony, K.B.2
Martinez-Wilson, H.3
-
56
-
-
22144470799
-
-
Sereti I, Imamichi H, Natarajan V, et al.: In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients. J Clin Invest 2005, 115:1839-1847. This study demonstrates how IL-2 may paradoxically lead to sustained decreases in T-cell activation by expanding regulatory T cells, leading to sustained CD4+ T-cell expansion.
-
Sereti I, Imamichi H, Natarajan V, et al.: In vivo expansion of CD4CD45RO-CD25 T cells expressing foxP3 in IL-2-treated HIV-infected patients. J Clin Invest 2005, 115:1839-1847. This study demonstrates how IL-2 may paradoxically lead to sustained decreases in T-cell activation by expanding regulatory T cells, leading to sustained CD4+ T-cell expansion.
-
-
-
-
57
-
-
0035895656
-
Placebo-controlled trial of prednisone in advanced HIV-1 infection
-
McComsey GA, Whalen CC, Mawhorter SD, et al.: Placebo-controlled trial of prednisone in advanced HIV-1 infection. AIDS 2001, 15:321-327.
-
(2001)
AIDS
, vol.15
, pp. 321-327
-
-
McComsey, G.A.1
Whalen, C.C.2
Mawhorter, S.D.3
-
58
-
-
0035958764
-
Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression
-
Havlir DV, Gilbert PB, Bennett K, et al.: Effects of treatment intensification with hydroxyurea in HIV-infected patients with virologic suppression. AIDS 2001, 15:1379-1388.
-
(2001)
AIDS
, vol.15
, pp. 1379-1388
-
-
Havlir, D.V.1
Gilbert, P.B.2
Bennett, K.3
-
59
-
-
0036534889
-
Placebo-controlled trial of cyclosporine-A in HIV-1 disease: Implications for solid organ transplantation
-
Calabrese LH, Lederman MM, Spritzler J, et al.: Placebo-controlled trial of cyclosporine-A in HIV-1 disease: implications for solid organ transplantation. J Acquir Immune Defic Syndr 2002, 29:356-362.
-
(2002)
J Acquir Immune Defic Syndr
, vol.29
, pp. 356-362
-
-
Calabrese, L.H.1
Lederman, M.M.2
Spritzler, J.3
-
60
-
-
3843110460
-
Highly active antiretroviral therapy with or without mycophenolate mofetil in treatment-naive HIV-1 patients
-
Sankatsing SU, Jurriaans S, van Swieten P, et al.: Highly active antiretroviral therapy with or without mycophenolate mofetil in treatment-naive HIV-1 patients. AIDS 2004, 18:1925-1931.
-
(2004)
AIDS
, vol.18
, pp. 1925-1931
-
-
Sankatsing, S.U.1
Jurriaans, S.2
van Swieten, P.3
-
61
-
-
33845429615
-
Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: Results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138
-
Lederman MM, Smeaton L, Smith KY, et al.: Cyclosporin A provides no sustained immunologic benefit to persons with chronic HIV-1 infection starting suppressive antiretroviral therapy: results of a randomized, controlled trial of the AIDS Clinical Trials Group A5138. J Infect Dis 2006, 194:1677-1685.
-
(2006)
J Infect Dis
, vol.194
, pp. 1677-1685
-
-
Lederman, M.M.1
Smeaton, L.2
Smith, K.Y.3
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