CD4+ T cell recovery beyond the first year of complete suppression of viral replication during highly active antiretroviral therapy is not influenced by CD8+ T cell activation

Journal of Infectious Diseases

Volumn 192, Issue 12, 2005, Pages 2142-2146

  Benito, José M ^a   López, Mariola ^a   Lozano, Sara ^a   Ballesteros, Celia ^a   Capa, Laura ^a   Martinez, Pilar ^a   González Lahoz, Juan ^a   Soriano, Vincent ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD38 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; VIRUS RNA;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REPLICATION;

ANTIGENS, CD38; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HIV; HIV INFECTIONS; HUMANS; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTE SUBSETS; VIRAL LOAD; VIREMIA; VIRUS REPLICATION;

EID: 28844459523     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/498168     Document Type: Article

References (15)

1. Benito J, Zabay J, Gil J, et al. Quantitative alterations of the functionally distinct subsets of CD4 and CD8 T lymphocytes in asymptomatic HIV infection: changes in the expression of CD45RO, CD45RA, CD38, CD11b, HLA-DR, and CD25 antigens. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 14:128-35.
2. + T cells levels: results of 6 years follow-up. J Acquir Immune Defic Syndr 1993; 6:904-12.
3. + T cells in HIV-infected patients. AIDS 1996; 10:827-34.
4. + adolescent population. AIDS Res Hum Retroviruses 2004; 20:263-9.
5. + T lymphocyte activation status and plasma HIV RNA levels during antiretroviral therapy. AIDS 1998; 12:1267-73.
6. Valdez H, Connick E, Smith K, et al. Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease. AIDS 2002; 16:1859-66.
7. + T cells under successful highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2005; 38:373-81.
8. + T cell gains in HIV-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis 2003; 187:1534-43.
9. + T lymphocytes as a marker of residual virus replication in chronically HIV-infected patients receiving antiretroviral therapy. AIDS Res Hum Retroviruses 2004; 20:227-33.
10. Diggle PJ, Liang KY, Zeger SL. Fitting smooth curves to longitudinal data. In: Atkinson AC, Copas JB, Pierce DA, Schervish MJ, Titterington DM, eds. Analysis of longitudinal data. Oxford: Oxford University Press, 1994:41-7.
11. + T cells as a marker of poor response to therapy in HIV-infected individuals. Chem Immunol 2000; 75:207-17.
12. Karlson A, Younger S, Martin J, et al. Immunologic and virologic evolution during periods of intermittent and persistent low-level viraemia. AIDS 2004; 18:981-9.
13. Kaufman G, Bloch M, Finlayson R, Zaunders J, Smith D, Cooper D. The extent of HIV-related immunodeficiency and age predict the long-term CD4 T lymphocyte response to potent antiretroviral therapy. AIDS 2002; 16:359-67.
14. Marcelin A, Martínez V, Morini J. Very low levels of plasma HIV-1 viremia in subjects with sustained suppression of viremia <50 copies/ml can influence the recovery of CD4 cell counts after initiating HAART promoting the occurrence of transient viremic episodes. Antiviral Ther 2004; 9(Suppl):72.
15. Teixeira L, Valdez H, McCune J, et al. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 2001; 15:1749-56.