메뉴 건너뛰기




Volumn 12, Issue 14, 1998, Pages 1833-1844

Immunologic effects of combined protease inhibitor and reverse transcriptase inhibitor therapy in previously treated chronic HIV-1 infection

Author keywords

Immune reconstitution; Lymphocyte subsets; Protease inhibitors

Indexed keywords

CD28 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; DIDANOSINE; LAMIVUDINE; MONOCLONAL ANTIBODY; PADGEM PROTEIN; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; VIRUS RNA; ZALCITABINE; ZIDOVUDINE;

EID: 0032188878     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199814000-00015     Document Type: Article
Times cited : (66)

References (49)
  • 1
    • 0002012392 scopus 로고    scopus 로고
    • Phenotype and function of T tells in HIV disease
    • Edited by Gupta S, New York: Plenum Press
    • Giorgi JV: Phenotype and function of T tells in HIV disease. In Immunology of HIV Infection. Edited by Gupta S, New York: Plenum Press; 1996:181-199.
    • (1996) Immunology of HIV Infection , pp. 181-199
    • Giorgi, J.V.1
  • 2
    • 0030052964 scopus 로고    scopus 로고
    • Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir
    • Kelleher AD, Zaunders ACJ, Cooper DA: Alterations in the immune response of human immunodeficiency virus (HIV)-infected subjects treated with an HIV-specific protease inhibitor, ritonavir. J Infect Dis 1996, 173:321-329.
    • (1996) J Infect Dis , vol.173 , pp. 321-329
    • Kelleher, A.D.1    Zaunders, A.C.J.2    Cooper, D.A.3
  • 3
    • 0030868897 scopus 로고    scopus 로고
    • Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
    • Autran B, Carcelain G, Li TS, et al.: Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 1997, 277:112-116.
    • (1997) Science , vol.277 , pp. 112-116
    • Autran, B.1    Carcelain, G.2    Li, T.S.3
  • 4
    • 0031882434 scopus 로고    scopus 로고
    • Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
    • Pakker NG, Notermans DW, de Boer R, et al.: Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: a composite of redistribution and proliferation. Nat Med 1998, 4:208-214.
    • (1998) Nat Med , vol.4 , pp. 208-214
    • Pakker, N.G.1    Notermans, D.W.2    De Boer, R.3
  • 5
    • 17344365057 scopus 로고    scopus 로고
    • Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: Results of Clinical Trials Group Protocol 315
    • Lederman M, Connick E, Landay A, et al.: Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: Results of Clinical Trials Group Protocol 315. J Infect Dis 1998, 178:70-79.
    • (1998) J Infect Dis , vol.178 , pp. 70-79
    • Lederman, M.1    Connick, E.2    Landay, A.3
  • 6
    • 0025800401 scopus 로고
    • Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection
    • Fauci AS, Schnittman SM, Poli G, Koenig S, Pantaleo G: Immunopathogenic mechanisms in human immunodeficiency virus (HIV) infection. Ann Intern Med 1991, 114:678-692.
    • (1991) Ann Intern Med , vol.114 , pp. 678-692
    • Fauci, A.S.1    Schnittman, S.M.2    Poli, G.3    Koenig, S.4    Pantaleo, G.5
  • 7
    • 0027160334 scopus 로고
    • Characterization of T lymphocyte subset alterations by flow cytometry in HIV disease
    • Giorgi JV: Characterization of T lymphocyte subset alterations by flow cytometry in HIV disease. Ann NY Acad Sci 1993, 677:126-137.
    • (1993) Ann NY Acad Sci , vol.677 , pp. 126-137
    • Giorgi, J.V.1
  • 10
    • 0027263308 scopus 로고
    • Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens
    • Ho H-N, Hultin LE, Mitsuyasu RL, et al.: Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens. J Immunol 1993, 150:3070-3079.
    • (1993) J Immunol , vol.150 , pp. 3070-3079
    • Ho, H.-N.1    Hultin, L.E.2    Mitsuyasu, R.L.3
  • 11
    • 0003290437 scopus 로고
    • Immunodeficiency and infectious diseases
    • Edited by Rose NR, de Macario EC, Fahey JL, Friedman H, Penn GM, Washington, DC: American Society of Microbiology
    • Giorgi JV, Kesson AM, Chou C-C: Immunodeficiency and infectious diseases. In Manual of Clinical Laboratory Immunology. Edited by Rose NR, de Macario EC, Fahey JL, Friedman H, Penn GM, Washington, DC: American Society of Microbiology; 1992:174-181.
    • (1992) Manual of Clinical Laboratory Immunology , pp. 174-181
    • Giorgi, J.V.1    Kesson, A.M.2    Chou, C.-C.3
  • 13
    • 0001199710 scopus 로고
    • Reactivity of workshop T-cell section mAb with circulating CD4+ and CD8+ T cells in HIV disease and following in vitro activation
    • Edited by Schlossman SF, Boumsell L, Gilks W, et al. Oxford: Oxford University Press
    • Giorgi JV, Boumsell L, Autran B: Reactivity of workshop T-cell section mAb with circulating CD4+ and CD8+ T cells in HIV disease and following in vitro activation. In Leucocyte Typing V: White Cell Differentiation Antigens. Edited by Schlossman SF, Boumsell L, Gilks W, et al. Oxford: Oxford University Press; 1995:446-461.
    • (1995) Leucocyte Typing V: White Cell Differentiation Antigens , pp. 446-461
    • Giorgi, J.V.1    Boumsell, L.2    Autran, B.3
  • 14
    • 0027304957 scopus 로고
    • Elevated levels of CD38 + CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: Results of 6 years of follow-up
    • Giorgi JV, Liu Z, Hultin LE, Cumberland WG, Hennessey K, Detels R: Elevated levels of CD38 + CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. J Acquir Immune Defic Syndr 1993, 6:904-912.
    • (1993) J Acquir Immune Defic Syndr , vol.6 , pp. 904-912
    • Giorgi, J.V.1    Liu, Z.2    Hultin, L.E.3    Cumberland, W.G.4    Hennessey, K.5    Detels, R.6
  • 15
    • 0027965585 scopus 로고
    • CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of HLA-DR + CD38-CD8+ cells is associated with subsequent stable CD4+ cell levels
    • Giorgi JV, Ho H-N, Hirji K, et al.: CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR + CD38-CD8+ cells is associated with subsequent stable CD4+ cell levels. J Infect Dis 1994, 170:775-781.
    • (1994) J Infect Dis , vol.170 , pp. 775-781
    • Giorgi, J.V.1    Ho, H.-N.2    Hirji, K.3
  • 17
    • 0027945584 scopus 로고
    • Expression of CD28 on CD8+ and CD4+ lymphocytes during HIV infection
    • Caruso A, Cantalamessa A, Licenziati S, et al.: Expression of CD28 on CD8+ and CD4+ lymphocytes during HIV infection. Scand J Immunol 1994, 40:485-490.
    • (1994) Scand J Immunol , vol.40 , pp. 485-490
    • Caruso, A.1    Cantalamessa, A.2    Licenziati, S.3
  • 18
    • 0028203633 scopus 로고
    • Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: Functional and clinical correlations
    • Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T: Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J Infect Dis 1994, 169:730-738.
    • (1994) J Infect Dis , vol.169 , pp. 730-738
    • Brinchmann, J.E.1    Dobloug, J.H.2    Heger, B.H.3    Haaheim, L.L.4    Sannes, M.5    Egeland, T.6
  • 19
    • 0028785967 scopus 로고
    • Role of apoptosis in HIV disease pathogenesis
    • Oyaizu N, Pahwa S: Role of apoptosis in HIV disease pathogenesis. J Clin Immunol 1995, 15:217-231.
    • (1995) J Clin Immunol , vol.15 , pp. 217-231
    • Oyaizu, N.1    Pahwa, S.2
  • 20
    • 0027259137 scopus 로고
    • Lymphocyte activation in HIV-1 infection. I. Predominant proliferative defects among CD45RO+ cells of the CD4 and CD8 lineages
    • Janossy G, Borthwick N, Lomnitzer R, et al.: Lymphocyte activation in HIV-1 infection. I. Predominant proliferative defects among CD45RO+ cells of the CD4 and CD8 lineages. AIDS 1991, 7:613-624.
    • (1991) AIDS , vol.7 , pp. 613-624
    • Janossy, G.1    Borthwick, N.2    Lomnitzer, R.3
  • 21
    • 0025831154 scopus 로고
    • Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection
    • Prince HE, Jensen ER: Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection. J Acquir Immune Defic Syndr 1991, 4:1227-1232.
    • (1991) J Acquir Immune Defic Syndr , vol.4 , pp. 1227-1232
    • Prince, H.E.1    Jensen, E.R.2
  • 22
    • 0026694144 scopus 로고
    • Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection
    • Kestens L, Vanham C, Gigase P, et al.: Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection. AIDS 1992, 6:793-797.
    • (1992) AIDS , vol.6 , pp. 793-797
    • Kestens, L.1    Vanham, C.2    Gigase, P.3
  • 23
    • 0024323752 scopus 로고
    • T-cell subset alterations in HIV-infected homosexual men: NIAID Multicenter AIDS Cohort Study
    • Giorgi JV, Detels R: T-cell subset alterations in HIV-infected homosexual men: NIAID Multicenter AIDS Cohort Study. Clin Immunol Immunopathol 1989, 52:10-18.
    • (1989) Clin Immunol Immunopathol , vol.52 , pp. 10-18
    • Giorgi, J.V.1    Detels, R.2
  • 24
    • 0030045992 scopus 로고    scopus 로고
    • Correlation of CD8 lymphocyte activation with cellular viremia and plasma HIV RNA levels in asymptomatic patient infected by human immunodeficiency virus type 1
    • Bouscarat F, Levacher-Clergeot M, Dazza M-C, et al.: Correlation of CD8 lymphocyte activation with cellular viremia and plasma HIV RNA levels in asymptomatic patient infected by human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 1996, 12:17-24.
    • (1996) AIDS Res Hum Retroviruses , vol.12 , pp. 17-24
    • Bouscarat, F.1    Levacher-Clergeot, M.2    Dazza, M.-C.3
  • 25
    • 0031958156 scopus 로고    scopus 로고
    • Major expansions of select CD8+ subsets in acute EBV infection: Comparison with chronic HIV disease
    • Lynne JE, Schmid J, Matud JL, et al.: Major expansions of select CD8+ subsets in acute EBV infection: comparison with chronic HIV disease. J Infect Dis 1998, 177:1083-1087.
    • (1998) J Infect Dis , vol.177 , pp. 1083-1087
    • Lynne, J.E.1    Schmid, J.2    Matud, J.L.3
  • 26
    • 0029084730 scopus 로고
    • Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity
    • Ferbas J, Kaplan AH, Hausner MA, et al.: Virus burden in long-term survivors of human immunodeficiency virus (HIV) infection is a determinant of anti-HIV CD8+ lymphocyte activity. J Infect Dis 1995, 172:329-339.
    • (1995) J Infect Dis , vol.172 , pp. 329-339
    • Ferbas, J.1    Kaplan, A.H.2    Hausner, M.A.3
  • 27
    • 0027441767 scopus 로고
    • Subsets of CD8+ , CD57+ cells in normal, healthy individuals: Correlation with human cytomegalovirus (HCMV) carrier status, phenotype and functional analyses
    • Wang ECY, Taylor-Wiedman J, Perera P, Fisher J, Borysiewicz IK: Subsets of CD8+ , CD57+ cells in normal, healthy individuals: correlation with human cytomegalovirus (HCMV) carrier status, phenotype and functional analyses. Clin Exp Immunol 1993, 94:297-305.
    • (1993) Clin Exp Immunol , vol.94 , pp. 297-305
    • Wang, E.C.Y.1    Taylor-Wiedman, J.2    Perera, P.3    Fisher, J.4    Borysiewicz, I.K.5
  • 28
    • 0027976958 scopus 로고
    • Clonal populations of T cells in normal elderly humans: The T cell equivalent to 'benign monoclonal gammapathy'
    • Posnett DN, Sinha R, Kabak S, Russo C: Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammapathy'. J Exp Med 1994, 179:609-618.
    • (1994) J Exp Med , vol.179 , pp. 609-618
    • Posnett, D.N.1    Sinha, R.2    Kabak, S.3    Russo, C.4
  • 29
    • 0031068033 scopus 로고
    • Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia
    • Serrano D, Monteiro J, Allen SL, et al.: Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. J Immunol 1947, 158:1482-1489.
    • (1947) J Immunol , vol.158 , pp. 1482-1489
    • Serrano, D.1    Monteiro, J.2    Allen, S.L.3
  • 30
    • 7344230117 scopus 로고    scopus 로고
    • Detailed immunophenotype of CD8+ memory CTL against HIV-1 with respect to expression of CD45RA/RO, CD62L and CD28 antigens
    • in press
    • Giorgi JV, Hausner MA, Hultin LE: Detailed immunophenotype of CD8+ memory CTL against HIV-1 with respect to expression of CD45RA/RO, CD62L and CD28 antigens. Immunol Lett 1998 (in press).
    • (1998) Immunol Lett
    • Giorgi, J.V.1    Hausner, M.A.2    Hultin, L.E.3
  • 31
    • 0029968318 scopus 로고    scopus 로고
    • Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts
    • Monteiro I, Batliwalla FM, Ostrer H, Gregersen PK: Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol 1996, 156:3587-3590.
    • (1996) J Immunol , vol.156 , pp. 3587-3590
    • Monteiro, I.1    Batliwalla, F.M.2    Ostrer, H.3    Gregersen, P.K.4
  • 32
    • 8944258925 scopus 로고    scopus 로고
    • Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
    • Effros RB, Allsopp R, Chiu C-P, et al.: Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 1996, 10:F17-F22.
    • (1996) AIDS , vol.10
    • Effros, R.B.1    Allsopp, R.2    Chiu, C.-P.3
  • 33
    • 0029041822 scopus 로고
    • Expression of the Fas antigen in patients infected with human immunodeficiency virus
    • McCloskey TW, Oyaizu N, Kaplan M, Pahwa S: Expression of the Fas antigen in patients infected with human immunodeficiency virus. Cytometry 1993, 22:111-114.
    • (1993) Cytometry , vol.22 , pp. 111-114
    • McCloskey, T.W.1    Oyaizu, N.2    Kaplan, M.3    Pahwa, S.4
  • 34
    • 0021339890 scopus 로고
    • Quantitative changes in T helper or T suppressor cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders
    • Fahey JL, Prince H, Weaver M, et al.: Quantitative changes in T helper or T suppressor cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders. Am J Med 1984, 76:93-100.
    • (1984) Am J Med , vol.76 , pp. 93-100
    • Fahey, J.L.1    Prince, H.2    Weaver, M.3
  • 35
    • 0023186650 scopus 로고
    • The Multicenter AIDS Cohort Study: Rationale, organization, and selected characteristics of the participants
    • Kaslow RA, Ostrow DG, Detels R, Phair JP, Polk BF, Rinaldo CR Jr: The Multicenter AIDS Cohort Study: rationale, organization, and selected characteristics of the participants. Am J Epidemiol 1987, 126:310-318.
    • (1987) Am J Epidemiol , vol.126 , pp. 310-318
    • Kaslow, R.A.1    Ostrow, D.G.2    Detels, R.3    Phair, J.P.4    Polk, B.F.5    Rinaldo Jr., C.R.6
  • 36
    • 0023247365 scopus 로고
    • Factors associated with prevalent human immunodeficiency virus (HIV) infection in the Multicenter AIDS Cohort Study
    • Chmiel JS, Detels R, Kaslow RA, et al.: Factors associated with prevalent human immunodeficiency virus (HIV) infection in the Multicenter AIDS Cohort Study. Am J Epidemiol 1987, 126:568-577.
    • (1987) Am J Epidemiol , vol.126 , pp. 568-577
    • Chmiel, J.S.1    Detels, R.2    Kaslow, R.A.3
  • 37
    • 0028069547 scopus 로고
    • Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: Application to acute retroviral infection
    • Mulder J, McKinney N, Christopherson C, Sninsky J, Greenfield L, Kwok S: Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection. J Clin Microbiol 1994, 32:292-300.
    • (1994) J Clin Microbiol , vol.32 , pp. 292-300
    • Mulder, J.1    McKinney, N.2    Christopherson, C.3    Sninsky, J.4    Greenfield, L.5    Kwok, S.6
  • 38
    • 0032190567 scopus 로고    scopus 로고
    • Quantitation of CD38 activation antigen expression on CD8+ T cells in HIV-1 infection using CD4 expression on CD4+ T lymphocytes as a biological calibrator
    • in press
    • Hultin L, Matud J, Giorgi JV: Quantitation of CD38 activation antigen expression on CD8+ T cells in HIV-1 infection using CD4 expression on CD4+ T lymphocytes as a biological calibrator. Cytometry 1998 (in press).
    • (1998) Cytometry
    • Hultin, L.1    Matud, J.2    Giorgi, J.V.3
  • 40
    • 85038553976 scopus 로고
    • Boston: Cytel Software, Inc.
    • StatXact (Version 3.01) Boston: Cytel Software, Inc.; 1975.
    • (1975) StatXact (Version 3.01)
  • 44
    • 0024594430 scopus 로고
    • Seroconversion, sexual activity, and condom use among 2915 HIV seronegative men followed for up to 2 years
    • Detels R, English P, Visscher BR, et al.: Seroconversion, sexual activity, and condom use among 2915 HIV seronegative men followed for up to 2 years. J Acquir Immune Defic Syndr 1989, 2:77-83.
    • (1989) J Acquir Immune Defic Syndr , vol.2 , pp. 77-83
    • Detels, R.1    English, P.2    Visscher, B.R.3
  • 45
    • 0030668834 scopus 로고    scopus 로고
    • Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the multicenter AIDS cohort study than CD4+ cell count, soluble immune activation markers or combinations of HLA-DR and CD38 expression
    • Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, Giorgi JV: Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the multicenter AIDS cohort study than CD4+ cell count, soluble immune activation markers or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol 1997, 16:83-92.
    • (1997) J Acquir Immune Defic Syndr Hum Retrovirol , vol.16 , pp. 83-92
    • Liu, Z.1    Cumberland, W.G.2    Hultin, L.E.3    Prince, H.E.4    Detels, R.5    Giorgi, J.V.6
  • 46
    • 0028173859 scopus 로고
    • Phenotypically defined memory CD4+ cells are not selectively decreased in chronic HIV disease
    • Chou C-C, Gudeman V, O'Rourke S, et al.: Phenotypically defined memory CD4+ cells are not selectively decreased in chronic HIV disease. J Acquir Immune Defic Syndr 1994, 7:665-675.
    • (1994) J Acquir Immune Defic Syndr , vol.7 , pp. 665-675
    • Chou, C.-C.1    Gudeman, V.2    O'Rourke, S.3
  • 47
    • 16944367032 scopus 로고    scopus 로고
    • HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies
    • Connors M, Kovacs JA, Krevat S, et al.: HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nat Med 1997, 3:533-540.
    • (1997) Nat Med , vol.3 , pp. 533-540
    • Connors, M.1    Kovacs, J.A.2    Krevat, S.3
  • 48
    • 0027299647 scopus 로고
    • The impaired in vitro production of interleukin-2 in HIV infection is negatively correlated to the number of circulating CD4+DR+ T cells and is reversed by allowing T cells to rest in culture: Arguments for in vivo CD4+ T cell activation
    • Lees O, Ramzaoui S, Gilbert D, et al.: The impaired in vitro production of interleukin-2 in HIV infection is negatively correlated to the number of circulating CD4+DR+ T cells and is reversed by allowing T cells to rest in culture: arguments for in vivo CD4+ T cell activation. Clin Immunol Immunopathol 1993, 67:185-191.
    • (1993) Clin Immunol Immunopathol , vol.67 , pp. 185-191
    • Lees, O.1    Ramzaoui, S.2    Gilbert, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.