Discordant CD4 T lymphocyte responses to antiretroviral therapy for HIV infection are associated with ex-vivo rates of apoptosis

AIDS

Volumn 15, Issue 10, 2001, Pages 1317-1319

  Pitrak, D L ^a   Bolanos J ^a   Hershow, R ^a   Novak, R M ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT;

ADULT; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS LOAD;

ADULT; ANTI-HIV AGENTS; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; HIV INFECTIONS; HUMANS; MALE; MIDDLE AGED; RNA, VIRAL; VIRAL LOAD;

EID: 0035816396     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200107060-00018     Document Type: Article

References (10)

1. Researchers air alternative views on how HIV kills cells
2. Rapid turnover of plasma virions and CD4+ lymphocytes in HIV-1 infection
3. CD4 cell counts at the third month of HAART may predict clinical failure
4. Susceptibility of peripheal blood mononuclear cells apoptosis is related to plasma viral load
5. Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy
6. Downregulation of Bcl-2, but not of Bax or Bcl-x, is associated with T lymphocyte apoptosis in HIV infection and restored by antiretroviral therapy or interleukin 2
7. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
8. Rapid turnover of T lymphocytes in HIV-1 infection and its reduction by HAART: A kinetic study using deuterated glucose
9. Poor CD4+ T-cell responses after suppression of HIV replication may reflect thymic failure
10. Human immunodeficiency virus type 1 protease inhibitor modulates activation of peripheral blood CD4(+) T cells and decreases their susceptibility to apoptosis in vitro and in vivo